Comparison of the predictive capability of antral follicle count vs. the anti-Müllerian hormone for ovarian response in infertile women
ObjectivesThe aim of this study was to compare the predictive capability of antral follicle count (AFC) and the anti-Müllerian hormone (AMH) on ovarian response in infertile women and to identify potential factors influencing retrieved oocytes.MethodsA total of 2585 infertile women who underwent in...
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| Format: | Article |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.862733/full |
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| author | Xingyu Sun Wang Xiong Liting Liu Junjun Xiong Chenlu Liao Yunzhu Lan Feifei Li Shufei Tao Muzi Meng Muzi Meng Chenyu Sun Xiguang Mao |
| author_facet | Xingyu Sun Wang Xiong Liting Liu Junjun Xiong Chenlu Liao Yunzhu Lan Feifei Li Shufei Tao Muzi Meng Muzi Meng Chenyu Sun Xiguang Mao |
| author_sort | Xingyu Sun |
| collection | DOAJ |
| description | ObjectivesThe aim of this study was to compare the predictive capability of antral follicle count (AFC) and the anti-Müllerian hormone (AMH) on ovarian response in infertile women and to identify potential factors influencing retrieved oocytes.MethodsA total of 2585 infertile women who underwent in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles had been enrolled in this study. Spearman correlation was used to investigate the correlation between retrieved oocytes and AFC. Multiple linear regression analysis was used to study the parameters affecting the number of retrieved oocytes.ResultsSpearman correlation and multiple linear regression analysis revealed that the oocyte retrieval number was positively correlated with AFC (r = 0.651, p < 0.001) and AMH (r = 0.566, p < 0.001) and negatively correlated with age (r = -0.425, p < 0.001) and regimen selection (r = -0.233 p < 0.001). There was no significant correlation between retrieved oocytes and BMI (p = 0.913). ROC analysis revealed that AFC was a better predictor of adverse effects than AMH, BMI, and age (AUC: 0.916 VS 0.791, 0.575, 0.752). Meanwhile, AFC and AMH were comparable in predicting high response (AUC = 0.731 and AUC = 0.733, respectively).ConclusionsThis study showed that retrieved oocytes were positively correlated with serum AMH and AFC and negatively correlated with age and BMI. AFC had an ideal predictive performance in ovarian response prediction. The mechanism of the effect of AFC on ovarian response during controlled ovarian hyperstimulation (COH) needs to be further investigated. |
| first_indexed | 2024-04-11T23:50:55Z |
| format | Article |
| id | doaj.art-53fa1fd22d084fab92d179591a58574d |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T23:50:55Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-53fa1fd22d084fab92d179591a58574d2022-12-22T03:56:30ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-10-011310.3389/fendo.2022.862733862733Comparison of the predictive capability of antral follicle count vs. the anti-Müllerian hormone for ovarian response in infertile womenXingyu Sun0Wang Xiong1Liting Liu2Junjun Xiong3Chenlu Liao4Yunzhu Lan5Feifei Li6Shufei Tao7Muzi Meng8Muzi Meng9Chenyu Sun10Xiguang Mao11Department of Gynecology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Gynecology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Gynecology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Gynecology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Ophthalmology, The First People’s Hospital of Neijiang, Neijiang, ChinaDepartment of Gynecology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Gynecology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaFamily Medicine, Carle Foundation Hospital, Urbana, IL, United StatesAmerican University of the Caribbean School of Medicine, Preston, United KingdomBronxcare Health System, The Bronx, NY, United StatesAMITA Health Saint Joseph Hospital Chicago, Chicago, IL, United StatesDepartment of Gynecology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, ChinaObjectivesThe aim of this study was to compare the predictive capability of antral follicle count (AFC) and the anti-Müllerian hormone (AMH) on ovarian response in infertile women and to identify potential factors influencing retrieved oocytes.MethodsA total of 2585 infertile women who underwent in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles had been enrolled in this study. Spearman correlation was used to investigate the correlation between retrieved oocytes and AFC. Multiple linear regression analysis was used to study the parameters affecting the number of retrieved oocytes.ResultsSpearman correlation and multiple linear regression analysis revealed that the oocyte retrieval number was positively correlated with AFC (r = 0.651, p < 0.001) and AMH (r = 0.566, p < 0.001) and negatively correlated with age (r = -0.425, p < 0.001) and regimen selection (r = -0.233 p < 0.001). There was no significant correlation between retrieved oocytes and BMI (p = 0.913). ROC analysis revealed that AFC was a better predictor of adverse effects than AMH, BMI, and age (AUC: 0.916 VS 0.791, 0.575, 0.752). Meanwhile, AFC and AMH were comparable in predicting high response (AUC = 0.731 and AUC = 0.733, respectively).ConclusionsThis study showed that retrieved oocytes were positively correlated with serum AMH and AFC and negatively correlated with age and BMI. AFC had an ideal predictive performance in ovarian response prediction. The mechanism of the effect of AFC on ovarian response during controlled ovarian hyperstimulation (COH) needs to be further investigated.https://www.frontiersin.org/articles/10.3389/fendo.2022.862733/fullAnti-Mullerian hormoneAntral follicle countFemale infertilityIn vitro fertilization-embryo transferOvarian response |
| spellingShingle | Xingyu Sun Wang Xiong Liting Liu Junjun Xiong Chenlu Liao Yunzhu Lan Feifei Li Shufei Tao Muzi Meng Muzi Meng Chenyu Sun Xiguang Mao Comparison of the predictive capability of antral follicle count vs. the anti-Müllerian hormone for ovarian response in infertile women Frontiers in Endocrinology Anti-Mullerian hormone Antral follicle count Female infertility In vitro fertilization-embryo transfer Ovarian response |
| title | Comparison of the predictive capability of antral follicle count vs. the anti-Müllerian hormone for ovarian response in infertile women |
| title_full | Comparison of the predictive capability of antral follicle count vs. the anti-Müllerian hormone for ovarian response in infertile women |
| title_fullStr | Comparison of the predictive capability of antral follicle count vs. the anti-Müllerian hormone for ovarian response in infertile women |
| title_full_unstemmed | Comparison of the predictive capability of antral follicle count vs. the anti-Müllerian hormone for ovarian response in infertile women |
| title_short | Comparison of the predictive capability of antral follicle count vs. the anti-Müllerian hormone for ovarian response in infertile women |
| title_sort | comparison of the predictive capability of antral follicle count vs the anti mullerian hormone for ovarian response in infertile women |
| topic | Anti-Mullerian hormone Antral follicle count Female infertility In vitro fertilization-embryo transfer Ovarian response |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.862733/full |
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