Exploring Clinical Risk Factors for Breast Cancer Among American Indian Women
ObjectiveVery little is known about the breast cancer risk profile among American Indian women. Previous research shows that the proportion of American Indian/Alaska Native women with baseline characteristics (commonly known breast cancer risk factors) differs from other ethnicities. This retrospect...
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| Formato: | Artigo |
| Idioma: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Public Health |
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| Acceso en liña: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.840280/full |
| _version_ | 1828815000533204992 |
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| author | Melanie Nadeau Lyle G. Best Marilyn G. Klug Kathryn Wise |
| author_facet | Melanie Nadeau Lyle G. Best Marilyn G. Klug Kathryn Wise |
| author_sort | Melanie Nadeau |
| collection | DOAJ |
| description | ObjectiveVery little is known about the breast cancer risk profile among American Indian women. Previous research shows that the proportion of American Indian/Alaska Native women with baseline characteristics (commonly known breast cancer risk factors) differs from other ethnicities. This retrospective case control study was designed to the explore the association of these factors among American Indian women with and without breast cancer.MethodsCases and controls were retrospectively selected from the medical records of American Indian women who obtained their health care from Quentin N. Burdick Memorial Health Care Facility (Indian Health Service) in Belcourt, ND. For each woman with breast cancer (n = 141), two controls were selected when possible (n = 278). Risk factors examined included woman's age, age at first live birth, age of menarche, the number of previous benign breast biopsies, the total number of first-degree relatives with breast cancer, body mass index and parity. Odds ratios and 95% confidence intervals were calculated using logistic regression.ResultsMany of the associations found among American Indian women who obtained their health care from Quentin N. Burdick Memorial Health Care Facility (Indian Health Service) in Belcourt, ND, between risk factors commonly identified in other populations and breast cancer were weakly positive. Nulliparity was the only risk factor to consistently show a positive significant association (OR = 2.87, 95% CI 1.16–0.7.12).ConclusionDisparities in breast cancer incidence, mortality and screening among Northern Plains American Indian emphasize the need to better understand the risk factors associated with breast cancer in this population. Based on the results of this study, the value of current risk prediction models in American Indian communities is uncertain and clinicians should be cautious in using these models to inform American Indian patients of their risk for breast cancer. |
| first_indexed | 2024-12-12T10:35:58Z |
| format | Article |
| id | doaj.art-53faa34c3a4a402e901b789704afe6f1 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-12-12T10:35:58Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-53faa34c3a4a402e901b789704afe6f12022-12-22T00:27:13ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-06-011010.3389/fpubh.2022.840280840280Exploring Clinical Risk Factors for Breast Cancer Among American Indian WomenMelanie Nadeau0Lyle G. Best1Marilyn G. Klug2Kathryn Wise3Department of Indigenous Health, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, United StatesTurtle Mountain Community College, Belcourt, ND, United StatesDepartment of Population Health, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, United StatesDepartment of Population Health, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, United StatesObjectiveVery little is known about the breast cancer risk profile among American Indian women. Previous research shows that the proportion of American Indian/Alaska Native women with baseline characteristics (commonly known breast cancer risk factors) differs from other ethnicities. This retrospective case control study was designed to the explore the association of these factors among American Indian women with and without breast cancer.MethodsCases and controls were retrospectively selected from the medical records of American Indian women who obtained their health care from Quentin N. Burdick Memorial Health Care Facility (Indian Health Service) in Belcourt, ND. For each woman with breast cancer (n = 141), two controls were selected when possible (n = 278). Risk factors examined included woman's age, age at first live birth, age of menarche, the number of previous benign breast biopsies, the total number of first-degree relatives with breast cancer, body mass index and parity. Odds ratios and 95% confidence intervals were calculated using logistic regression.ResultsMany of the associations found among American Indian women who obtained their health care from Quentin N. Burdick Memorial Health Care Facility (Indian Health Service) in Belcourt, ND, between risk factors commonly identified in other populations and breast cancer were weakly positive. Nulliparity was the only risk factor to consistently show a positive significant association (OR = 2.87, 95% CI 1.16–0.7.12).ConclusionDisparities in breast cancer incidence, mortality and screening among Northern Plains American Indian emphasize the need to better understand the risk factors associated with breast cancer in this population. Based on the results of this study, the value of current risk prediction models in American Indian communities is uncertain and clinicians should be cautious in using these models to inform American Indian patients of their risk for breast cancer.https://www.frontiersin.org/articles/10.3389/fpubh.2022.840280/fullAmerican Indianbreast cancerepidemiologyrisk factorshealth disparities |
| spellingShingle | Melanie Nadeau Lyle G. Best Marilyn G. Klug Kathryn Wise Exploring Clinical Risk Factors for Breast Cancer Among American Indian Women Frontiers in Public Health American Indian breast cancer epidemiology risk factors health disparities |
| title | Exploring Clinical Risk Factors for Breast Cancer Among American Indian Women |
| title_full | Exploring Clinical Risk Factors for Breast Cancer Among American Indian Women |
| title_fullStr | Exploring Clinical Risk Factors for Breast Cancer Among American Indian Women |
| title_full_unstemmed | Exploring Clinical Risk Factors for Breast Cancer Among American Indian Women |
| title_short | Exploring Clinical Risk Factors for Breast Cancer Among American Indian Women |
| title_sort | exploring clinical risk factors for breast cancer among american indian women |
| topic | American Indian breast cancer epidemiology risk factors health disparities |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.840280/full |
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