Adjuvant chemotherapy options for early stage non-small cell lung cancer
For many years adjuvant chemotherapy has been a standard treatment after complete resection in malignancies such as breast and colon but only recently has its use become standard in early stage non-small cell lung cancer (NSCLC). Although surgery is regarded as the best possible treatment for early...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2011-11-01
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Series: | Frontiers in Oncology |
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2011.00045/full |
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author | Manali ePatel Heather A Wakelee |
author_facet | Manali ePatel Heather A Wakelee |
author_sort | Manali ePatel |
collection | DOAJ |
description | For many years adjuvant chemotherapy has been a standard treatment after complete resection in malignancies such as breast and colon but only recently has its use become standard in early stage non-small cell lung cancer (NSCLC). Although surgery is regarded as the best possible treatment for early stage NSCLC, only 20-25% of patients have resectable disease at presentation. Despite optimal surgical treatment, five-year survival rates for NSCLC remain 50-60% for stage IB, 40%-50% for stage II, and 20-30% for stage III (Kohler 2011; Siegel 2011). Adjuvant chemotherapy provides additional survival benefit in resected NSCLC but questions remain as to how to select patients for therapy and which regimen is best. Other than work with tegafur/uracil in Japan, the positive adjuvant trials have all utilized a cisplatin backbone, but the drug(s) to pair with cisplatin are a matter of debate and will be discussed further in this manuscript. |
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format | Article |
id | doaj.art-53fd0ff67fed42b09b1bf1357b3a1160 |
institution | Directory Open Access Journal |
issn | 2234-943X |
language | English |
last_indexed | 2024-12-10T22:50:25Z |
publishDate | 2011-11-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Oncology |
spelling | doaj.art-53fd0ff67fed42b09b1bf1357b3a11602022-12-22T01:30:26ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2011-11-01110.3389/fonc.2011.0004515959Adjuvant chemotherapy options for early stage non-small cell lung cancerManali ePatel0Heather A Wakelee1Stanford UniversityStanford UniversityFor many years adjuvant chemotherapy has been a standard treatment after complete resection in malignancies such as breast and colon but only recently has its use become standard in early stage non-small cell lung cancer (NSCLC). Although surgery is regarded as the best possible treatment for early stage NSCLC, only 20-25% of patients have resectable disease at presentation. Despite optimal surgical treatment, five-year survival rates for NSCLC remain 50-60% for stage IB, 40%-50% for stage II, and 20-30% for stage III (Kohler 2011; Siegel 2011). Adjuvant chemotherapy provides additional survival benefit in resected NSCLC but questions remain as to how to select patients for therapy and which regimen is best. Other than work with tegafur/uracil in Japan, the positive adjuvant trials have all utilized a cisplatin backbone, but the drug(s) to pair with cisplatin are a matter of debate and will be discussed further in this manuscript.http://journal.frontiersin.org/Journal/10.3389/fonc.2011.00045/fullchemotherapylung cancerTreatmentadjuvantoptionsselection |
spellingShingle | Manali ePatel Heather A Wakelee Adjuvant chemotherapy options for early stage non-small cell lung cancer Frontiers in Oncology chemotherapy lung cancer Treatment adjuvant options selection |
title | Adjuvant chemotherapy options for early stage non-small cell lung cancer |
title_full | Adjuvant chemotherapy options for early stage non-small cell lung cancer |
title_fullStr | Adjuvant chemotherapy options for early stage non-small cell lung cancer |
title_full_unstemmed | Adjuvant chemotherapy options for early stage non-small cell lung cancer |
title_short | Adjuvant chemotherapy options for early stage non-small cell lung cancer |
title_sort | adjuvant chemotherapy options for early stage non small cell lung cancer |
topic | chemotherapy lung cancer Treatment adjuvant options selection |
url | http://journal.frontiersin.org/Journal/10.3389/fonc.2011.00045/full |
work_keys_str_mv | AT manaliepatel adjuvantchemotherapyoptionsforearlystagenonsmallcelllungcancer AT heatherawakelee adjuvantchemotherapyoptionsforearlystagenonsmallcelllungcancer |