Evaluation of the hepatotoxicity of Psoralea corylifolia L. based on a zebrafish model

Evaluation of the hepatotoxicity of Psoralea corylifolia L. based on a zebrafish model

Objective:Psoralea corylifolia L. (FP) has received increasing attention due to its potential hepatotoxicity.Methods: In this study, zebrafish were treated with different concentrations of an aqueous extract of FP (AEFP; 40, 50, or 60 μg/mL), and the hepatotoxic effects of tonicity were determined b...

Full description

Bibliographic Details
Main Authors:	Shu-Yan Gao, Jing-Cheng Zhao, Qing Xia, Chen Sun, Maimaiti Aili, Ainiwaer Talifu, Shi-Xia Huo, Yun Zhang, Zhi-Jian Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-02-01
Series:	Frontiers in Pharmacology
Subjects:	Psoralea corylifolia L. hepatotoxicity zebrafish cholestony lipid metabolism
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1308655/full

Similar Items

Pharmacologically Active Secondary Metabolites from Psoralea corylifolia
by: Ni Putu Ariantari, et al.
Published: (2022-11-01)

Phytochemical and antimicrobial activity screening of seeds of Psoralea corylifolia L.
by: M.M.V. Baig
Published: (2022-05-01)

Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus
by: Yanmei Cui, et al.
Published: (2015-07-01)

Progress of Psoralea corylifolia injection in the treatment of vitiligo
by: Han LIU, et al.
Published: (2023-10-01)

Quality Control of <i>Psoralea corylifolia</i> L. Based on High-Speed Countercurrent Chromatographic Fingerprinting
by: Xiaoxue Wu, et al.
Published: (2020-01-01)

Dietary Total Prenylflavonoids from the Fruits of Psoralea corylifolia L. Prevents Age-Related Cognitive Deficits and Down-Regulates Alzheimer’s Markers in SAMP8 Mice
by: Zhi-Jing Chen, et al.
Published: (2018-01-01)

In vitro and in vivo assessment of the effect of antiprotozoal compounds isolated from Psoralea corylifolia against Ichthyophthirius multifiliis in fish
by: Kaige Song, et al.
Published: (2015-08-01)

Correlation Analysis between the Active Ingredients and the Antioxidant or Cholate-binding Ability of Ethanol Extracts from Psoralea corylifolia L.
by: Xinyang JIANG, et al.
Published: (2022-07-01)

Two Novel Polysaccharides in <i>Psoralea corylifolia</i> L and anti-A549 Lung Cancer Cells Activity <i>In Vitro</i>
by: Zhenhua Yin, et al.
Published: (2019-10-01)

Seed Extract of Psoralea corylifolia and Its Constituent Bakuchiol Impairs AHL-Based Quorum Sensing and Biofilm Formation in Food- and Human-Related Pathogens
by: Fohad Mabood Husain, et al.
Published: (2018-10-01)

Psoralea corylifolia L. Attenuates Nonalcoholic Steatohepatitis in Juvenile Mouse
by: Lishan Zhou, et al.
Published: (2017-11-01)

Odontogenic Differentiation-Induced Tooth Regeneration by <i>Psoralea corylifolia</i> L.
by: Hye-Ock Jang, et al.
Published: (2022-05-01)

Insecticidal and genotoxic activity of <it>Psoralea corylifolia</it> Linn. (Fabaceae) against <it>Culex quinquefasciatus</it> Say, 1823
by: Dua Virendra K, et al.
Published: (2013-02-01)

New bakuchiol dimers from Psoraleae Fructus and their inhibitory activities on nitric oxide production
by: Qingxia Xu, et al.
Published: (2021-10-01)

Targeting JAK/STAT signaling pathway and anti-inflammatory markers using bakuchiol isolated from Psoralea corylifolia for cytotoxicity of human squamous cell carcinoma (A431) cells
by: Shivani Attri, et al.
Published: (2023-08-01)

Bavachin from Psoralea corylifolia Improves Insulin-Dependent Glucose Uptake through Insulin Signaling and AMPK Activation in 3T3-L1 Adipocytes
by: Hyejin Lee, et al.
Published: (2016-04-01)

<i>Psoralea corylifolia</i> L. Ameliorates Collagen-Induced Arthritis by Reducing Proinflammatory Cytokines and Upregulating Myeloid-Derived Suppressor Cells
by: Fu-Tzu Pai, et al.
Published: (2021-06-01)

Exploration of Antimicrobial Ingredients in <i>Psoralea corylifolia </i>L. Seed and Related Mechanism against Methicillin-Resistant <i>Staphylococcus aureus</i>
by: Liqiong Sun, et al.
Published: (2022-10-01)

P soralea corylifolia L.: a comprehensive review of its botany, traditional uses, phytochemistry, pharmacology, toxicology, quality control and pharmacokinetics
by: Lele Chen, et al.
Published: (2023-01-01)

Acute liver failure associated with Fructus Psoraleae: a case report and literature review
by: Ang Li, et al.
Published: (2019-04-01)

CYP3A4 inhibition by Psoralea corylifolia and its major components in human recombinant enzyme, differentiated human hepatoma HuH-7 and HepaRG cells
by: Yitong Liu, et al.
Published: (2015-01-01)

Yin/Yang associated differential responses to Psoralea corylifolia Linn. In rat models: an integrated metabolomics and transcriptomics study
by: Ming-Liang Zhang, et al.
Published: (2023-08-01)

Five Constituents Contributed to the Psoraleae Fructus-Induced Hepatotoxicity via Mitochondrial Dysfunction and Apoptosis
by: Zhaojuan Guo, et al.
Published: (2021-12-01)

Evaluation of toxicity and anti-osteoporosis effect in rats treated with the flavonoids of Psoraleae Fructus
by: Bojia Liu, et al.
Published: (2020-12-01)

Five Constituents in Psoralea corylifolia L. Attenuate Palmitic Acid-Induced Hepatocyte Injury via Inhibiting the Protein Kinase C-α/Nicotinamide-Adenine Dinucleotide Phosphate Oxidase Pathway
by: Lishan Zhou, et al.
Published: (2020-01-01)

Encapsulation of Babchi Oil in Cyclodextrin-Based Nanosponges: Physicochemical Characterization, Photodegradation, and In Vitro Cytotoxicity Studies
by: Sunil Kumar, et al.
Published: (2018-09-01)

Fabrication of anti-vitiligo ointment containing Psoralea corylifolia: in vitro and in vivo characterization
by: Hussain I, et al.
Published: (2016-11-01)

An evaluation of adverse drug reactions of Bakuchi containing formulations used in the management of Shvitra (vitiligo): A retrospective, observational record-based study
by: Sarika Makwana, et al.
Published: (2023-01-01)

Bakuchiol, a natural constituent and its pharmacological benefits [version 2; peer review: 2 approved]
by: Sohel Mahmud, et al.
Published: (2023-11-01)

HBX-6, Standardized <i>Cornus officinalis</i> and <i>Psoralea corylifolia</i> L. Extracts, Suppresses Benign Prostate Hyperplasia by Attenuating E2F1 Activation
by: Bo-Ram Jin, et al.
Published: (2019-05-01)

Pharmacological Activities of Psoralidin: A Comprehensive Review of the Molecular Mechanisms of Action
by: Javad Sharifi-Rad, et al.
Published: (2020-10-01)

Bavachin alleviates diabetic nephropathy in db/db mice by inhibition of oxidative stress and improvement of mitochondria function
by: Jisu Park, et al.
Published: (2023-05-01)

Inflammation aggravated the hepatotoxicity of triptolide by oxidative stress, lipid metabolism disorder, autophagy, and apoptosis in zebrafish
by: Chenqinyao Li, et al.
Published: (2022-08-01)

Phototoxicity activity of Psoralea drupacea L. using Atremia salina bioassay system
by: Mohammad Ramezani, et al.
Published: (2011-07-01)

Fraxinellone Induces Hepatotoxicity in Zebrafish through Oxidative Stress and the Transporters Pathway
by: Shuting Wang, et al.
Published: (2022-04-01)

Effects of Fructus Psoraleae Extract on the Intestinal Absorption Kinetics of Geniposide and Geniposidic Acid in Rat
by: Yan Huo, et al.
Published: (2014-06-01)

Hazard identification of phthalates based on hepatotoxicity of zebrafish larvae
by: WANG Xiaohong, et al.
Published: (2022-09-01)

Histomorphometric Study of Fructus Psoralea on Ethanol Induced Neurodegeneration of Hippocampus in Rat
by: Sivanandan Ramar, et al.
Published: (2013-08-01)

Effect of P. corylifolia on the pharmacokinetic profile of tofacitinib and the underlying mechanism
by: Yu Wang, et al.
Published: (2024-04-01)

Transformation of Psoralen and Isopsoralen by Human Intestinal Microbial In Vitro, and the Biological Activities of Its Metabolites
by: Lu Liu, et al.
Published: (2019-11-01)