Role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation
Thrombosis is a frequent cause of cardiovascular mortality and hospitalization. Current antithrombotic strategies, however, target both thrombosis and physiological hemostasis and thereby increase bleeding risk. In recent years the pathophysiological understanding of thrombus formation has significa...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-04-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1151926/full |
| _version_ | 1797851710710874112 |
|---|---|
| author | Qing Zhang Qing Zhang Qurrat Ul Ain Christian Schulz Christian Schulz Joachim Pircher Joachim Pircher |
| author_facet | Qing Zhang Qing Zhang Qurrat Ul Ain Christian Schulz Christian Schulz Joachim Pircher Joachim Pircher |
| author_sort | Qing Zhang |
| collection | DOAJ |
| description | Thrombosis is a frequent cause of cardiovascular mortality and hospitalization. Current antithrombotic strategies, however, target both thrombosis and physiological hemostasis and thereby increase bleeding risk. In recent years the pathophysiological understanding of thrombus formation has significantly advanced and inflammation has become a crucial element. Neutrophils as most frequent immune cells in the blood and their released mediators play a key role herein. Neutrophil-derived cathelicidin next to its strong antimicrobial properties has also shown to modulates thrombosis and thus presents a potential therapeutic target. In this article we review direct and indirect (immune- and endothelial cell-mediated) effects of cathelicidin on platelets and the coagulation system. Further we discuss its implications for large vessel thrombosis and consecutive thromboinflammation as well as immunothrombosis in sepsis and COVID-19 and give an outlook for potential therapeutic prospects. |
| first_indexed | 2024-04-09T19:21:06Z |
| format | Article |
| id | doaj.art-53ff38cb42b744bab3d6b7bc795dd89d |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T19:21:06Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-53ff38cb42b744bab3d6b7bc795dd89d2023-04-05T10:15:30ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-04-011410.3389/fimmu.2023.11519261151926Role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammationQing Zhang0Qing Zhang1Qurrat Ul Ain2Christian Schulz3Christian Schulz4Joachim Pircher5Joachim Pircher6Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Ludwig-Maximilians- Universität, Munich, GermanyPartner Site Munich Heart Alliance, DZHK (German Centre for Cardiovascular Research), Munich, GermanyMedizinische Klinik und Poliklinik I, Klinikum der Universität München, Ludwig-Maximilians- Universität, Munich, GermanyMedizinische Klinik und Poliklinik I, Klinikum der Universität München, Ludwig-Maximilians- Universität, Munich, GermanyPartner Site Munich Heart Alliance, DZHK (German Centre for Cardiovascular Research), Munich, GermanyMedizinische Klinik und Poliklinik I, Klinikum der Universität München, Ludwig-Maximilians- Universität, Munich, GermanyPartner Site Munich Heart Alliance, DZHK (German Centre for Cardiovascular Research), Munich, GermanyThrombosis is a frequent cause of cardiovascular mortality and hospitalization. Current antithrombotic strategies, however, target both thrombosis and physiological hemostasis and thereby increase bleeding risk. In recent years the pathophysiological understanding of thrombus formation has significantly advanced and inflammation has become a crucial element. Neutrophils as most frequent immune cells in the blood and their released mediators play a key role herein. Neutrophil-derived cathelicidin next to its strong antimicrobial properties has also shown to modulates thrombosis and thus presents a potential therapeutic target. In this article we review direct and indirect (immune- and endothelial cell-mediated) effects of cathelicidin on platelets and the coagulation system. Further we discuss its implications for large vessel thrombosis and consecutive thromboinflammation as well as immunothrombosis in sepsis and COVID-19 and give an outlook for potential therapeutic prospects.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1151926/fullthrombosisimmunothrombosiscathelicidin (LL-37)plateletsthromboinflammationLL-37 |
| spellingShingle | Qing Zhang Qing Zhang Qurrat Ul Ain Christian Schulz Christian Schulz Joachim Pircher Joachim Pircher Role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation Frontiers in Immunology thrombosis immunothrombosis cathelicidin (LL-37) platelets thromboinflammation LL-37 |
| title | Role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation |
| title_full | Role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation |
| title_fullStr | Role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation |
| title_full_unstemmed | Role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation |
| title_short | Role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation |
| title_sort | role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation |
| topic | thrombosis immunothrombosis cathelicidin (LL-37) platelets thromboinflammation LL-37 |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1151926/full |
| work_keys_str_mv | AT qingzhang roleofantimicrobialpeptidecathelicidininthrombosisandthromboinflammation AT qingzhang roleofantimicrobialpeptidecathelicidininthrombosisandthromboinflammation AT qurratulain roleofantimicrobialpeptidecathelicidininthrombosisandthromboinflammation AT christianschulz roleofantimicrobialpeptidecathelicidininthrombosisandthromboinflammation AT christianschulz roleofantimicrobialpeptidecathelicidininthrombosisandthromboinflammation AT joachimpircher roleofantimicrobialpeptidecathelicidininthrombosisandthromboinflammation AT joachimpircher roleofantimicrobialpeptidecathelicidininthrombosisandthromboinflammation |