Pannexins Are Potential New Players in the Regulation of Cerebral Homeostasis during Sleep-Wake Cycle
During brain homeostasis, both neurons and astroglia release ATP that is rapidly converted to adenosine in the extracellular space. Pannexin-1 (Panx1) hemichannels represent a major conduit of non-vesicular ATP release from brain cells. Previous studies have shown that Panx1−/− mice possess severe d...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-07-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fncel.2017.00210/full |
| _version_ | 1819212512984301568 |
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| author | Valery I. Shestopalov Valery I. Shestopalov Valery I. Shestopalov Yuri Panchin Yuri Panchin Olga S. Tarasova Olga S. Tarasova Olga S. Tarasova Dina Gaynullina Dina Gaynullina Vladimir M. Kovalzon Vladimir M. Kovalzon |
| author_facet | Valery I. Shestopalov Valery I. Shestopalov Valery I. Shestopalov Yuri Panchin Yuri Panchin Olga S. Tarasova Olga S. Tarasova Olga S. Tarasova Dina Gaynullina Dina Gaynullina Vladimir M. Kovalzon Vladimir M. Kovalzon |
| author_sort | Valery I. Shestopalov |
| collection | DOAJ |
| description | During brain homeostasis, both neurons and astroglia release ATP that is rapidly converted to adenosine in the extracellular space. Pannexin-1 (Panx1) hemichannels represent a major conduit of non-vesicular ATP release from brain cells. Previous studies have shown that Panx1−/− mice possess severe disruption of the sleep-wake cycle. Here, we review experimental data supporting the involvement of pannexins (Panx) in the coordination of fundamental sleep-associated brain processes, such as neuronal activity and regulation of cerebrovascular tone. Panx1 hemichannels are likely implicated in the regulation of the sleep-wake cycle via an indirect effect of released ATP on adenosine receptors and through interaction with other somnogens, such as IL-1β, TNFα and prostaglandin D2. In addition to the recently established role of Panx1 in the regulation of endothelium-dependent arterial dilation, similar signaling pathways are the major cellular component of neurovascular coupling. The new discovered role of Panx in sleep regulation may have broad implications in coordinating neuronal activity and homeostatic housekeeping processes during the sleep-wake cycle. |
| first_indexed | 2024-12-23T06:44:09Z |
| format | Article |
| id | doaj.art-54013b3fda694d2e810665ba060afce6 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-23T06:44:09Z |
| publishDate | 2017-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-54013b3fda694d2e810665ba060afce62022-12-21T17:56:38ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022017-07-011110.3389/fncel.2017.00210273866Pannexins Are Potential New Players in the Regulation of Cerebral Homeostasis during Sleep-Wake CycleValery I. Shestopalov0Valery I. Shestopalov1Valery I. Shestopalov2Yuri Panchin3Yuri Panchin4Olga S. Tarasova5Olga S. Tarasova6Olga S. Tarasova7Dina Gaynullina8Dina Gaynullina9Vladimir M. Kovalzon10Vladimir M. Kovalzon11Institute for Information Transmission Problems, Russian Academy of SciencesMoscow, RussiaDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of MedicineMiami, FL, United StatesMicrobiology and Bioengineering Laboratory, Department of Genomics and Biotechnology, Vavilov Institute of General Genetics, Russian Academy of SciencesMoscow, RussiaInstitute for Information Transmission Problems, Russian Academy of SciencesMoscow, RussiaDepartment of Mathematical Methods in Biology, Belozersky Institute, M.V. Lomonosov Moscow State UniversityMoscow, RussiaInstitute for Information Transmission Problems, Russian Academy of SciencesMoscow, RussiaDepartment of Human and Animal Physiology, Faculty of Biology, M.V. Lomonosov Moscow State UniversityMoscow, RussiaState Research Center of the Russian Federation, Institute for Biomedical Problems, Russian Academy of SciencesMoscow, RussiaDepartment of Human and Animal Physiology, Faculty of Biology, M.V. Lomonosov Moscow State UniversityMoscow, RussiaDepartment of Physiology, Russian National Research Medical UniversityMoscow, RussiaInstitute for Information Transmission Problems, Russian Academy of SciencesMoscow, RussiaSevertsov Institute Ecology and Evolution, Russian Academy of SciencesMoscow, RussiaDuring brain homeostasis, both neurons and astroglia release ATP that is rapidly converted to adenosine in the extracellular space. Pannexin-1 (Panx1) hemichannels represent a major conduit of non-vesicular ATP release from brain cells. Previous studies have shown that Panx1−/− mice possess severe disruption of the sleep-wake cycle. Here, we review experimental data supporting the involvement of pannexins (Panx) in the coordination of fundamental sleep-associated brain processes, such as neuronal activity and regulation of cerebrovascular tone. Panx1 hemichannels are likely implicated in the regulation of the sleep-wake cycle via an indirect effect of released ATP on adenosine receptors and through interaction with other somnogens, such as IL-1β, TNFα and prostaglandin D2. In addition to the recently established role of Panx1 in the regulation of endothelium-dependent arterial dilation, similar signaling pathways are the major cellular component of neurovascular coupling. The new discovered role of Panx in sleep regulation may have broad implications in coordinating neuronal activity and homeostatic housekeeping processes during the sleep-wake cycle.http://journal.frontiersin.org/article/10.3389/fncel.2017.00210/fullpannexinsnon-REM sleeppurinergic systemcytokinesprostaglandin D2glymphatic system |
| spellingShingle | Valery I. Shestopalov Valery I. Shestopalov Valery I. Shestopalov Yuri Panchin Yuri Panchin Olga S. Tarasova Olga S. Tarasova Olga S. Tarasova Dina Gaynullina Dina Gaynullina Vladimir M. Kovalzon Vladimir M. Kovalzon Pannexins Are Potential New Players in the Regulation of Cerebral Homeostasis during Sleep-Wake Cycle Frontiers in Cellular Neuroscience pannexins non-REM sleep purinergic system cytokines prostaglandin D2 glymphatic system |
| title | Pannexins Are Potential New Players in the Regulation of Cerebral Homeostasis during Sleep-Wake Cycle |
| title_full | Pannexins Are Potential New Players in the Regulation of Cerebral Homeostasis during Sleep-Wake Cycle |
| title_fullStr | Pannexins Are Potential New Players in the Regulation of Cerebral Homeostasis during Sleep-Wake Cycle |
| title_full_unstemmed | Pannexins Are Potential New Players in the Regulation of Cerebral Homeostasis during Sleep-Wake Cycle |
| title_short | Pannexins Are Potential New Players in the Regulation of Cerebral Homeostasis during Sleep-Wake Cycle |
| title_sort | pannexins are potential new players in the regulation of cerebral homeostasis during sleep wake cycle |
| topic | pannexins non-REM sleep purinergic system cytokines prostaglandin D2 glymphatic system |
| url | http://journal.frontiersin.org/article/10.3389/fncel.2017.00210/full |
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