不同血糖状态和年龄变化的成年人动脉硬化风险的性别差异
Abstract Background Studies indicate lower, comparable, and higher cardiovascular risks in women vs men in normal glucose regulation (NGR), prediabetes, and diabetes, respectively. However, this sex difference is uncertain and aging might play a part. We aimed to estimate sex differences in arterial...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-02-01
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| Series: | Journal of Diabetes |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1753-0407.13353 |
| _version_ | 1797904625944231936 |
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| author | Xiaoyun Zhang Qianqian Yang Ruizhi Zheng Zhiyun Zhao Mian Li Tiange Wang Min Xu Jieli Lu Shuangyuan Wang Hong Lin Weiqing Wang Guang Ning Yufang Bi Yu Xu Yuhong Chen |
| author_facet | Xiaoyun Zhang Qianqian Yang Ruizhi Zheng Zhiyun Zhao Mian Li Tiange Wang Min Xu Jieli Lu Shuangyuan Wang Hong Lin Weiqing Wang Guang Ning Yufang Bi Yu Xu Yuhong Chen |
| author_sort | Xiaoyun Zhang |
| collection | DOAJ |
| description | Abstract Background Studies indicate lower, comparable, and higher cardiovascular risks in women vs men in normal glucose regulation (NGR), prediabetes, and diabetes, respectively. However, this sex difference is uncertain and aging might play a part. We aimed to estimate sex differences in arterial stiffness in NGR, prediabetes, or diabetes and the potential modifications by age. Methods We used baseline data of 9618 participants aged ≥40 years in a large community‐based cohort study in Shanghai. Glycemic status was determined by history of diabetes, fasting and 2‐h post‐load glucose levels, and hemoglobin A1c levels. Arterial stiffness was examined by brachial‐ankle pulse wave velocity (ba‐PWV). Multivariable linear regression analysis was conducted to examine the associations between sex and ba‐PWV levels in glycemic and age categories. Results Before adjustment for age, women had lower, comparable, and higher ba‐PWV vs men in the NGR, prediabetes, and diabetes groups, respectively. In participants aged 40–59 years, women were associated with lower ba‐PWV levels in generally all glycemic strata after adjustment for age and other confounders. In participants aged ≥60 years, women were associated with significantly higher ba‐PWV levels (β coefficient = 71.5; 95% confidence interval = 23.4, 119.7) and the sex difference was attenuated in the groups of prediabetes and diabetes with a borderline significant interaction between sex and glycemic status (p for interaction = .068). Conclusions The sex difference in cardiovascular risks in adults with NGR, prediabetes, or diabetes was dependent on age. Our findings provide new evidence for prioritizing preventive treatment against atherosclerosis in men vs women with different glycemic status. |
| first_indexed | 2024-04-10T09:51:58Z |
| format | Article |
| id | doaj.art-54022c14c30c456a9fab392a96351778 |
| institution | Directory Open Access Journal |
| issn | 1753-0393 1753-0407 |
| language | English |
| last_indexed | 2024-04-10T09:51:58Z |
| publishDate | 2023-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes |
| spelling | doaj.art-54022c14c30c456a9fab392a963517782023-02-16T23:09:18ZengWileyJournal of Diabetes1753-03931753-04072023-02-0115212113210.1111/1753-0407.13353不同血糖状态和年龄变化的成年人动脉硬化风险的性别差异Xiaoyun Zhang0Qianqian Yang1Ruizhi Zheng2Zhiyun Zhao3Mian Li4Tiange Wang5Min Xu6Jieli Lu7Shuangyuan Wang8Hong Lin9Weiqing Wang10Guang Ning11Yufang Bi12Yu Xu13Yuhong Chen14Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai ChinaDepartment of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai ChinaDepartment of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai ChinaDepartment of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai ChinaDepartment of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai ChinaDepartment of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai ChinaDepartment of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai ChinaDepartment of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai ChinaDepartment of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai ChinaDepartment of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai ChinaDepartment of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai ChinaDepartment of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai ChinaDepartment of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai ChinaDepartment of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai ChinaDepartment of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai ChinaAbstract Background Studies indicate lower, comparable, and higher cardiovascular risks in women vs men in normal glucose regulation (NGR), prediabetes, and diabetes, respectively. However, this sex difference is uncertain and aging might play a part. We aimed to estimate sex differences in arterial stiffness in NGR, prediabetes, or diabetes and the potential modifications by age. Methods We used baseline data of 9618 participants aged ≥40 years in a large community‐based cohort study in Shanghai. Glycemic status was determined by history of diabetes, fasting and 2‐h post‐load glucose levels, and hemoglobin A1c levels. Arterial stiffness was examined by brachial‐ankle pulse wave velocity (ba‐PWV). Multivariable linear regression analysis was conducted to examine the associations between sex and ba‐PWV levels in glycemic and age categories. Results Before adjustment for age, women had lower, comparable, and higher ba‐PWV vs men in the NGR, prediabetes, and diabetes groups, respectively. In participants aged 40–59 years, women were associated with lower ba‐PWV levels in generally all glycemic strata after adjustment for age and other confounders. In participants aged ≥60 years, women were associated with significantly higher ba‐PWV levels (β coefficient = 71.5; 95% confidence interval = 23.4, 119.7) and the sex difference was attenuated in the groups of prediabetes and diabetes with a borderline significant interaction between sex and glycemic status (p for interaction = .068). Conclusions The sex difference in cardiovascular risks in adults with NGR, prediabetes, or diabetes was dependent on age. Our findings provide new evidence for prioritizing preventive treatment against atherosclerosis in men vs women with different glycemic status.https://doi.org/10.1111/1753-0407.13353性别差异动脉硬化指数血糖状态年龄 |
| spellingShingle | Xiaoyun Zhang Qianqian Yang Ruizhi Zheng Zhiyun Zhao Mian Li Tiange Wang Min Xu Jieli Lu Shuangyuan Wang Hong Lin Weiqing Wang Guang Ning Yufang Bi Yu Xu Yuhong Chen 不同血糖状态和年龄变化的成年人动脉硬化风险的性别差异 Journal of Diabetes 性别差异 动脉硬化指数 血糖状态 年龄 |
| title | 不同血糖状态和年龄变化的成年人动脉硬化风险的性别差异 |
| title_full | 不同血糖状态和年龄变化的成年人动脉硬化风险的性别差异 |
| title_fullStr | 不同血糖状态和年龄变化的成年人动脉硬化风险的性别差异 |
| title_full_unstemmed | 不同血糖状态和年龄变化的成年人动脉硬化风险的性别差异 |
| title_short | 不同血糖状态和年龄变化的成年人动脉硬化风险的性别差异 |
| title_sort | 不同血糖状态和年龄变化的成年人动脉硬化风险的性别差异 |
| topic | 性别差异 动脉硬化指数 血糖状态 年龄 |
| url | https://doi.org/10.1111/1753-0407.13353 |
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