Arecoline promotes proliferation and migration of human HepG2 cells through activation of the PI3K/AKT/mTOR pathway

Arecoline promotes proliferation and migration of human HepG2 cells through activation of the PI3K/AKT/mTOR pathway

Abstract Background Arecoline is a well-known risk factor for oral submucosal fibrosis and cancer. However, the mechanistic correlation between arecoline and hepatocellular cancer remains elusive. Here, we investigated the effect of arecoline on the proliferation and migration of human HepG2 hepatom...

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Bibliographic Details
Main Authors: Hai Xie, Ren Jing, Xiaoting Liao, Haishao Chen, Xianlong Xie, Huijun Dai, Linghui Pan
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Hereditas
Subjects:
Arecoline
Hepatocellular cancer
Cell proliferation
Cell migration
PI3K/AKT/mTOR pathway
CDK1
Online Access:https://doi.org/10.1186/s41065-022-00241-0

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