The feasibility of white matter volume reduction analysis using SPM8 plus DARTEL for the diagnosis of patients with clinically diagnosed corticobasal syndrome and Richardson’s syndrome
Purpose: Diagnosing corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) is often difficult due to the wide variety of symptoms and overlaps in the similar clinical courses and neurological findings. The purpose of this study was to evaluate the utility of white matter (WM) atrop...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158214000278 |
| _version_ | 1818380402286395392 |
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| author | Keita Sakurai Etsuko Imabayashi Aya M. Tokumaru Shin Hasebe Shigeo Murayama Satoru Morimoto Kazutomi Kanemaru Masaki Takao Yuta Shibamoto Noriyuki Matsukawa |
| author_facet | Keita Sakurai Etsuko Imabayashi Aya M. Tokumaru Shin Hasebe Shigeo Murayama Satoru Morimoto Kazutomi Kanemaru Masaki Takao Yuta Shibamoto Noriyuki Matsukawa |
| author_sort | Keita Sakurai |
| collection | DOAJ |
| description | Purpose: Diagnosing corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) is often difficult due to the wide variety of symptoms and overlaps in the similar clinical courses and neurological findings. The purpose of this study was to evaluate the utility of white matter (WM) atrophy for the diagnosis of patients with clinically diagnosed CBD (corticobasal syndrome, CBS) and PSP (Richardson’s syndrome, RS).
Methods: We randomly divided the 3D T1-weighted MR images of 18 CBS patients, 33 RS patients, and 32 age-matched controls into two groups. We obtained segmented WM images in the first group using Voxel-based specific regional analysis system for Alzheimer’s disease (VSRAD) based on statistical parametric mapping (SPM) 8 plus diffeomorphic anatomical registration through exponentiated Lie algebra. A target volume of interest (VOI) for disease-specific atrophy was subsequently determined in this group using SPM8 group analyses of WM atrophy between patients groups and controls. We then evaluated the utility of these VOIs for diagnosing CBS and RS patients in the second group. Z score values in these VOIs were used as the determinant in receiver operating characteristic (ROC) analyses.
Results: Specific target VOIs were determined in the bilateral frontal subcortical WM for CBS and in the midbrain tegmentum for RS. In ROC analyses, the target VOIs of CBS and RS compared to those of controls exhibited an area under curve (AUC) of 0.99 and 0.84, respectively, which indicated an adequate diagnostic power. The VOI of CBS revealed a higher AUC than that of RS for differentiating between CBS and RS (AUC, 0.75 vs 0.53).
Conclusions: Bilateral frontal WM volume reduction demonstrated a higher power for differentiating CBS from RS. This VOI analysis is useful for clinically diagnosing CBS and RS. |
| first_indexed | 2024-12-14T02:18:07Z |
| format | Article |
| id | doaj.art-54091bd928804227ab7019bf1b7f3ce2 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-14T02:18:07Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-54091bd928804227ab7019bf1b7f3ce22022-12-21T23:20:34ZengElsevierNeuroImage: Clinical2213-15822015-01-017C60561010.1016/j.nicl.2014.02.009The feasibility of white matter volume reduction analysis using SPM8 plus DARTEL for the diagnosis of patients with clinically diagnosed corticobasal syndrome and Richardson’s syndromeKeita Sakurai0Etsuko Imabayashi1Aya M. Tokumaru2Shin Hasebe3Shigeo Murayama4Satoru Morimoto5Kazutomi Kanemaru6Masaki Takao7Yuta Shibamoto8Noriyuki Matsukawa9Department of Diagnostic Radiology, Tokyo Metropolitan Medical Center of GerontologyDepartment of Diagnostic Radiology, Tokyo Metropolitan Medical Center of GerontologyDepartment of Diagnostic Radiology, Tokyo Metropolitan Medical Center of GerontologyDepartment of Diagnostic Radiology, Tokyo Metropolitan Medical Center of GerontologyDepartment of Neurology, Tokyo Metropolitan Geriatric HospitalDepartment of Neurology, Tokyo Metropolitan Geriatric HospitalDepartment of Neurology, Tokyo Metropolitan Geriatric HospitalDepartment of Neuropathology (the Brain Bank for Aging Research), Tokyo Metropolitan Geriatric Hospital, Tokyo Metropolitan Geriatric Hospital and Institute of GerontologyDepartment of Radiology, Nagoya City University Graduate School of Medical SciencesDepartment of Neurology and Neuroscience, Nagoya City University Graduate School of Medical SciencesPurpose: Diagnosing corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) is often difficult due to the wide variety of symptoms and overlaps in the similar clinical courses and neurological findings. The purpose of this study was to evaluate the utility of white matter (WM) atrophy for the diagnosis of patients with clinically diagnosed CBD (corticobasal syndrome, CBS) and PSP (Richardson’s syndrome, RS). Methods: We randomly divided the 3D T1-weighted MR images of 18 CBS patients, 33 RS patients, and 32 age-matched controls into two groups. We obtained segmented WM images in the first group using Voxel-based specific regional analysis system for Alzheimer’s disease (VSRAD) based on statistical parametric mapping (SPM) 8 plus diffeomorphic anatomical registration through exponentiated Lie algebra. A target volume of interest (VOI) for disease-specific atrophy was subsequently determined in this group using SPM8 group analyses of WM atrophy between patients groups and controls. We then evaluated the utility of these VOIs for diagnosing CBS and RS patients in the second group. Z score values in these VOIs were used as the determinant in receiver operating characteristic (ROC) analyses. Results: Specific target VOIs were determined in the bilateral frontal subcortical WM for CBS and in the midbrain tegmentum for RS. In ROC analyses, the target VOIs of CBS and RS compared to those of controls exhibited an area under curve (AUC) of 0.99 and 0.84, respectively, which indicated an adequate diagnostic power. The VOI of CBS revealed a higher AUC than that of RS for differentiating between CBS and RS (AUC, 0.75 vs 0.53). Conclusions: Bilateral frontal WM volume reduction demonstrated a higher power for differentiating CBS from RS. This VOI analysis is useful for clinically diagnosing CBS and RS.http://www.sciencedirect.com/science/article/pii/S2213158214000278Corticobasal degeneration (CBD)Progressive supranuclear palsy (PSP)Statistical parametric mapping (SPM)Diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL)Voxel-based specific regional analysis system for Alzheimer’s disease (VSRAD) |
| spellingShingle | Keita Sakurai Etsuko Imabayashi Aya M. Tokumaru Shin Hasebe Shigeo Murayama Satoru Morimoto Kazutomi Kanemaru Masaki Takao Yuta Shibamoto Noriyuki Matsukawa The feasibility of white matter volume reduction analysis using SPM8 plus DARTEL for the diagnosis of patients with clinically diagnosed corticobasal syndrome and Richardson’s syndrome NeuroImage: Clinical Corticobasal degeneration (CBD) Progressive supranuclear palsy (PSP) Statistical parametric mapping (SPM) Diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL) Voxel-based specific regional analysis system for Alzheimer’s disease (VSRAD) |
| title | The feasibility of white matter volume reduction analysis using SPM8 plus DARTEL for the diagnosis of patients with clinically diagnosed corticobasal syndrome and Richardson’s syndrome |
| title_full | The feasibility of white matter volume reduction analysis using SPM8 plus DARTEL for the diagnosis of patients with clinically diagnosed corticobasal syndrome and Richardson’s syndrome |
| title_fullStr | The feasibility of white matter volume reduction analysis using SPM8 plus DARTEL for the diagnosis of patients with clinically diagnosed corticobasal syndrome and Richardson’s syndrome |
| title_full_unstemmed | The feasibility of white matter volume reduction analysis using SPM8 plus DARTEL for the diagnosis of patients with clinically diagnosed corticobasal syndrome and Richardson’s syndrome |
| title_short | The feasibility of white matter volume reduction analysis using SPM8 plus DARTEL for the diagnosis of patients with clinically diagnosed corticobasal syndrome and Richardson’s syndrome |
| title_sort | feasibility of white matter volume reduction analysis using spm8 plus dartel for the diagnosis of patients with clinically diagnosed corticobasal syndrome and richardson s syndrome |
| topic | Corticobasal degeneration (CBD) Progressive supranuclear palsy (PSP) Statistical parametric mapping (SPM) Diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL) Voxel-based specific regional analysis system for Alzheimer’s disease (VSRAD) |
| url | http://www.sciencedirect.com/science/article/pii/S2213158214000278 |
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