Low Serum Levels of Soluble Receptor Activator of Nuclear Factor κ B Ligand (sRANKL) Are Associated with Metabolic Dysregulation and Predict Long-Term Mortality in Critically Ill Patients
Soluble receptor activator of nuclear factor κ B ligand (sRANKL) is a member of the tumor necrosis factor receptor superfamily, and therefore, involved in various inflammatory processes. The role of sRANKL in the course of bone remodeling via activation of osteoclasts as well as chronic disease prog...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-12-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/12/1/62 |
| _version_ | 1827666034880937984 |
|---|---|
| author | Tobias Puengel Beate Weber Theresa H. Wirtz Lukas Buendgens Sven H. Loosen Lukas Geisler Burcin Özdirik Karim Hamesch Samira Abu Jhaisha Jonathan F. Brozat Philipp Hohlstein Albrecht Eisert Eray Yagmur Christian Trautwein Frank Tacke Alexander Koch |
| author_facet | Tobias Puengel Beate Weber Theresa H. Wirtz Lukas Buendgens Sven H. Loosen Lukas Geisler Burcin Özdirik Karim Hamesch Samira Abu Jhaisha Jonathan F. Brozat Philipp Hohlstein Albrecht Eisert Eray Yagmur Christian Trautwein Frank Tacke Alexander Koch |
| author_sort | Tobias Puengel |
| collection | DOAJ |
| description | Soluble receptor activator of nuclear factor κ B ligand (sRANKL) is a member of the tumor necrosis factor receptor superfamily, and therefore, involved in various inflammatory processes. The role of sRANKL in the course of bone remodeling via activation of osteoclasts as well as chronic disease progression has been described extensively. However, the potential functional importance of sRANKL in critically ill or septic patients remained unknown. Therefore, we measured sRANKL serum concentrations in 303 critically ill patients, including 203 patients with sepsis and 100 with non-sepsis critical illness. Results were compared to 99 healthy controls. Strikingly, in critically ill patients sRANKL serum levels were significantly decreased at intensive care unit (ICU) admission (<i>p</i> = 0.011) without differences between sepsis and non-sepsis patients. Inline, sRANKL was correlated with markers of metabolic dysregulation, such as pre-existing diabetes and various adipokines (e.g., adiponectin, leptin receptor). Importantly, overall mortality of critically ill patients in a three-year follow-up was significantly associated with decreased sRANKL serum concentrations at ICU admission (<i>p</i> = 0.038). Therefore, our study suggests sRANKL as a biomarker in critically ill patients which is associated with poor prognosis and overall survival beyond ICU stay. |
| first_indexed | 2024-03-10T01:39:19Z |
| format | Article |
| id | doaj.art-540bb2eab9084ad59a084d1375bdcb40 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T01:39:19Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-540bb2eab9084ad59a084d1375bdcb402023-11-23T13:27:37ZengMDPI AGDiagnostics2075-44182021-12-011216210.3390/diagnostics12010062Low Serum Levels of Soluble Receptor Activator of Nuclear Factor κ B Ligand (sRANKL) Are Associated with Metabolic Dysregulation and Predict Long-Term Mortality in Critically Ill PatientsTobias Puengel0Beate Weber1Theresa H. Wirtz2Lukas Buendgens3Sven H. Loosen4Lukas Geisler5Burcin Özdirik6Karim Hamesch7Samira Abu Jhaisha8Jonathan F. Brozat9Philipp Hohlstein10Albrecht Eisert11Eray Yagmur12Christian Trautwein13Frank Tacke14Alexander Koch15Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM), Charité-Universitätsmedizin Berlin, 13353 Berlin, GermanyDepartment of Medicine III, RWTH-University Hospital Aachen, 52074 Aachen, GermanyDepartment of Medicine III, RWTH-University Hospital Aachen, 52074 Aachen, GermanyDepartment of Medicine III, RWTH-University Hospital Aachen, 52074 Aachen, GermanyClinic for Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University Düsseldorf, 40225 Düsseldorf, GermanyDepartment of Hepatology and Gastroenterology, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM), Charité-Universitätsmedizin Berlin, 13353 Berlin, GermanyDepartment of Hepatology and Gastroenterology, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM), Charité-Universitätsmedizin Berlin, 13353 Berlin, GermanyDepartment of Medicine III, RWTH-University Hospital Aachen, 52074 Aachen, GermanyDepartment of Medicine III, RWTH-University Hospital Aachen, 52074 Aachen, GermanyDepartment of Medicine III, RWTH-University Hospital Aachen, 52074 Aachen, GermanyDepartment of Medicine III, RWTH-University Hospital Aachen, 52074 Aachen, GermanyHospital Pharmacy, RWTH-University Hospital Aachen, 52074 Aachen, GermanyInstitute of Laboratory Medicine, Western Palatinate Hospital, 67655 Kaiserslautern, GermanyDepartment of Medicine III, RWTH-University Hospital Aachen, 52074 Aachen, GermanyDepartment of Hepatology and Gastroenterology, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM), Charité-Universitätsmedizin Berlin, 13353 Berlin, GermanyDepartment of Medicine III, RWTH-University Hospital Aachen, 52074 Aachen, GermanySoluble receptor activator of nuclear factor κ B ligand (sRANKL) is a member of the tumor necrosis factor receptor superfamily, and therefore, involved in various inflammatory processes. The role of sRANKL in the course of bone remodeling via activation of osteoclasts as well as chronic disease progression has been described extensively. However, the potential functional importance of sRANKL in critically ill or septic patients remained unknown. Therefore, we measured sRANKL serum concentrations in 303 critically ill patients, including 203 patients with sepsis and 100 with non-sepsis critical illness. Results were compared to 99 healthy controls. Strikingly, in critically ill patients sRANKL serum levels were significantly decreased at intensive care unit (ICU) admission (<i>p</i> = 0.011) without differences between sepsis and non-sepsis patients. Inline, sRANKL was correlated with markers of metabolic dysregulation, such as pre-existing diabetes and various adipokines (e.g., adiponectin, leptin receptor). Importantly, overall mortality of critically ill patients in a three-year follow-up was significantly associated with decreased sRANKL serum concentrations at ICU admission (<i>p</i> = 0.038). Therefore, our study suggests sRANKL as a biomarker in critically ill patients which is associated with poor prognosis and overall survival beyond ICU stay.https://www.mdpi.com/2075-4418/12/1/62soluble receptor activator of nuclear factor κ B ligand (sRANKL)intensive care unit (ICU)critical illnessdiabetesglucose metabolismadipokine |
| spellingShingle | Tobias Puengel Beate Weber Theresa H. Wirtz Lukas Buendgens Sven H. Loosen Lukas Geisler Burcin Özdirik Karim Hamesch Samira Abu Jhaisha Jonathan F. Brozat Philipp Hohlstein Albrecht Eisert Eray Yagmur Christian Trautwein Frank Tacke Alexander Koch Low Serum Levels of Soluble Receptor Activator of Nuclear Factor κ B Ligand (sRANKL) Are Associated with Metabolic Dysregulation and Predict Long-Term Mortality in Critically Ill Patients Diagnostics soluble receptor activator of nuclear factor κ B ligand (sRANKL) intensive care unit (ICU) critical illness diabetes glucose metabolism adipokine |
| title | Low Serum Levels of Soluble Receptor Activator of Nuclear Factor κ B Ligand (sRANKL) Are Associated with Metabolic Dysregulation and Predict Long-Term Mortality in Critically Ill Patients |
| title_full | Low Serum Levels of Soluble Receptor Activator of Nuclear Factor κ B Ligand (sRANKL) Are Associated with Metabolic Dysregulation and Predict Long-Term Mortality in Critically Ill Patients |
| title_fullStr | Low Serum Levels of Soluble Receptor Activator of Nuclear Factor κ B Ligand (sRANKL) Are Associated with Metabolic Dysregulation and Predict Long-Term Mortality in Critically Ill Patients |
| title_full_unstemmed | Low Serum Levels of Soluble Receptor Activator of Nuclear Factor κ B Ligand (sRANKL) Are Associated with Metabolic Dysregulation and Predict Long-Term Mortality in Critically Ill Patients |
| title_short | Low Serum Levels of Soluble Receptor Activator of Nuclear Factor κ B Ligand (sRANKL) Are Associated with Metabolic Dysregulation and Predict Long-Term Mortality in Critically Ill Patients |
| title_sort | low serum levels of soluble receptor activator of nuclear factor κ b ligand srankl are associated with metabolic dysregulation and predict long term mortality in critically ill patients |
| topic | soluble receptor activator of nuclear factor κ B ligand (sRANKL) intensive care unit (ICU) critical illness diabetes glucose metabolism adipokine |
| url | https://www.mdpi.com/2075-4418/12/1/62 |
| work_keys_str_mv | AT tobiaspuengel lowserumlevelsofsolublereceptoractivatorofnuclearfactorkbligandsranklareassociatedwithmetabolicdysregulationandpredictlongtermmortalityincriticallyillpatients AT beateweber lowserumlevelsofsolublereceptoractivatorofnuclearfactorkbligandsranklareassociatedwithmetabolicdysregulationandpredictlongtermmortalityincriticallyillpatients AT theresahwirtz lowserumlevelsofsolublereceptoractivatorofnuclearfactorkbligandsranklareassociatedwithmetabolicdysregulationandpredictlongtermmortalityincriticallyillpatients AT lukasbuendgens lowserumlevelsofsolublereceptoractivatorofnuclearfactorkbligandsranklareassociatedwithmetabolicdysregulationandpredictlongtermmortalityincriticallyillpatients AT svenhloosen lowserumlevelsofsolublereceptoractivatorofnuclearfactorkbligandsranklareassociatedwithmetabolicdysregulationandpredictlongtermmortalityincriticallyillpatients AT lukasgeisler lowserumlevelsofsolublereceptoractivatorofnuclearfactorkbligandsranklareassociatedwithmetabolicdysregulationandpredictlongtermmortalityincriticallyillpatients AT burcinozdirik lowserumlevelsofsolublereceptoractivatorofnuclearfactorkbligandsranklareassociatedwithmetabolicdysregulationandpredictlongtermmortalityincriticallyillpatients AT karimhamesch lowserumlevelsofsolublereceptoractivatorofnuclearfactorkbligandsranklareassociatedwithmetabolicdysregulationandpredictlongtermmortalityincriticallyillpatients AT samiraabujhaisha lowserumlevelsofsolublereceptoractivatorofnuclearfactorkbligandsranklareassociatedwithmetabolicdysregulationandpredictlongtermmortalityincriticallyillpatients AT jonathanfbrozat lowserumlevelsofsolublereceptoractivatorofnuclearfactorkbligandsranklareassociatedwithmetabolicdysregulationandpredictlongtermmortalityincriticallyillpatients AT philipphohlstein lowserumlevelsofsolublereceptoractivatorofnuclearfactorkbligandsranklareassociatedwithmetabolicdysregulationandpredictlongtermmortalityincriticallyillpatients AT albrechteisert lowserumlevelsofsolublereceptoractivatorofnuclearfactorkbligandsranklareassociatedwithmetabolicdysregulationandpredictlongtermmortalityincriticallyillpatients AT erayyagmur lowserumlevelsofsolublereceptoractivatorofnuclearfactorkbligandsranklareassociatedwithmetabolicdysregulationandpredictlongtermmortalityincriticallyillpatients AT christiantrautwein lowserumlevelsofsolublereceptoractivatorofnuclearfactorkbligandsranklareassociatedwithmetabolicdysregulationandpredictlongtermmortalityincriticallyillpatients AT franktacke lowserumlevelsofsolublereceptoractivatorofnuclearfactorkbligandsranklareassociatedwithmetabolicdysregulationandpredictlongtermmortalityincriticallyillpatients AT alexanderkoch lowserumlevelsofsolublereceptoractivatorofnuclearfactorkbligandsranklareassociatedwithmetabolicdysregulationandpredictlongtermmortalityincriticallyillpatients |