Nanoparticle‐Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia‐Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myocardial Infarction

Nanoparticle‐Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia‐Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myocardial Infarction

BackgroundMitochondria‐mediated cell death plays a critical role in myocardial ischemia‐reperfusion (IR) injury. We hypothesized that nanoparticle‐mediated drug delivery of mitochondrial division inhibitor 1 (Mdivi1) protects hearts from IR injury through inhibition of mitochondria outer membrane pe...

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Bibliographic Details
Main Authors: Ayako Ishikita, Tetsuya Matoba, Gentaro Ikeda, Jun‐ichiro Koga, Yajing Mao, Kaku Nakano, Osamu Takeuchi, Junichi Sadoshima, Kensuke Egashira
Format: Article
Language:English
Published: Wiley 2016-07-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
drug delivery system
ischemia‐reperfusion injury
mitochondria
myocardial infarction
nanoparticle
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.116.003872

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