Recent Advances in Cell-Based Therapies for Ischemic Stroke
Stroke is the most prevalent cardiovascular disease worldwide, and is still one of the leading causes of death and disability. Stem cell-based therapy is actively being investigated as a new potential treatment for certain neurological disorders, including stroke. Various types of cells, including b...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/18/6718 |
| _version_ | 1797553777102815232 |
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| author | Satoshi Suda Chikako Nito Shoji Yokobori Yuki Sakamoto Masataka Nakajima Kota Sowa Hirofumi Obinata Kazuma Sasaki Sean I. Savitz Kazumi Kimura |
| author_facet | Satoshi Suda Chikako Nito Shoji Yokobori Yuki Sakamoto Masataka Nakajima Kota Sowa Hirofumi Obinata Kazuma Sasaki Sean I. Savitz Kazumi Kimura |
| author_sort | Satoshi Suda |
| collection | DOAJ |
| description | Stroke is the most prevalent cardiovascular disease worldwide, and is still one of the leading causes of death and disability. Stem cell-based therapy is actively being investigated as a new potential treatment for certain neurological disorders, including stroke. Various types of cells, including bone marrow mononuclear cells, bone marrow mesenchymal stem cells, dental pulp stem cells, neural stem cells, inducible pluripotent stem cells, and genetically modified stem cells have been found to improve neurological outcomes in animal models of stroke, and there are some ongoing clinical trials assessing their efficacy in humans. In this review, we aim to summarize the recent advances in cell-based therapies to treat stroke. |
| first_indexed | 2024-03-10T16:21:27Z |
| format | Article |
| id | doaj.art-540d35b3dcc9478299fc73151178204a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T16:21:27Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-540d35b3dcc9478299fc73151178204a2023-11-20T13:37:11ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-012118671810.3390/ijms21186718Recent Advances in Cell-Based Therapies for Ischemic StrokeSatoshi Suda0Chikako Nito1Shoji Yokobori2Yuki Sakamoto3Masataka Nakajima4Kota Sowa5Hirofumi Obinata6Kazuma Sasaki7Sean I. Savitz8Kazumi Kimura9Department of Neurology, Nippon Medical School, Tokyo 113-8602, JapanDepartment of Neurology, Nippon Medical School, Tokyo 113-8602, JapanDepartment of Emergency and Critical Care Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8602, JapanDepartment of Neurology, Nippon Medical School, Tokyo 113-8602, JapanDepartment of Neurology, Nippon Medical School, Tokyo 113-8602, JapanDepartment of Neurology, Nippon Medical School, Tokyo 113-8602, JapanDepartment of Emergency and Critical Care Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8602, JapanDepartment of Emergency and Critical Care Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8602, JapanInstitute for Stroke and Cerebrovascular Disease, UTHealth, Houston, TX 77030, USADepartment of Neurology, Nippon Medical School, Tokyo 113-8602, JapanStroke is the most prevalent cardiovascular disease worldwide, and is still one of the leading causes of death and disability. Stem cell-based therapy is actively being investigated as a new potential treatment for certain neurological disorders, including stroke. Various types of cells, including bone marrow mononuclear cells, bone marrow mesenchymal stem cells, dental pulp stem cells, neural stem cells, inducible pluripotent stem cells, and genetically modified stem cells have been found to improve neurological outcomes in animal models of stroke, and there are some ongoing clinical trials assessing their efficacy in humans. In this review, we aim to summarize the recent advances in cell-based therapies to treat stroke.https://www.mdpi.com/1422-0067/21/18/6718angiogenesisclinical trialinflammationneurogenesisstem cellstroke |
| spellingShingle | Satoshi Suda Chikako Nito Shoji Yokobori Yuki Sakamoto Masataka Nakajima Kota Sowa Hirofumi Obinata Kazuma Sasaki Sean I. Savitz Kazumi Kimura Recent Advances in Cell-Based Therapies for Ischemic Stroke International Journal of Molecular Sciences angiogenesis clinical trial inflammation neurogenesis stem cell stroke |
| title | Recent Advances in Cell-Based Therapies for Ischemic Stroke |
| title_full | Recent Advances in Cell-Based Therapies for Ischemic Stroke |
| title_fullStr | Recent Advances in Cell-Based Therapies for Ischemic Stroke |
| title_full_unstemmed | Recent Advances in Cell-Based Therapies for Ischemic Stroke |
| title_short | Recent Advances in Cell-Based Therapies for Ischemic Stroke |
| title_sort | recent advances in cell based therapies for ischemic stroke |
| topic | angiogenesis clinical trial inflammation neurogenesis stem cell stroke |
| url | https://www.mdpi.com/1422-0067/21/18/6718 |
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