Ciprofloxacin-loaded Chitosan Nanoparticles as Titanium Coatings: A Valuable Strategy to Prevent Implant-associated Infections
Orthopaedic infections represent one of the major causes of implant failure. Systemic treatment is limited due to dosing, side-effects, patient compliance, treatment length and resistant bacteria. The choice of antibiotic incorporation method has been the subject of many investigations and, nowadays...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2012-12-01
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| Series: | Nano Biomedicine and Engineering |
| Subjects: | |
| Online Access: | https://www.sciopen.com/article/10.5101/nbe.v4i4.p163-169 |
| _version_ | 1797673435651899392 |
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| author | Elvira De Giglio Adriana Trapani Damiana Cafagna Concetta Ferretti Roberta Iatta Stefania Cometa Edmondo Ceci Antonella Romanelli Monica Mattioli-Belmonte |
| author_facet | Elvira De Giglio Adriana Trapani Damiana Cafagna Concetta Ferretti Roberta Iatta Stefania Cometa Edmondo Ceci Antonella Romanelli Monica Mattioli-Belmonte |
| author_sort | Elvira De Giglio |
| collection | DOAJ |
| description | Orthopaedic infections represent one of the major causes of implant failure. Systemic treatment is limited due to dosing, side-effects, patient compliance, treatment length and resistant bacteria. The choice of antibiotic incorporation method has been the subject of many investigations and, nowadays, various vehicles for local drug delivery have been studied. In this work, a novel ciprofloxacin loaded chitosan nanoparticles coating system onto titanium surface has been developed and characterized. The antibiotic release capability of this system and its ability to inhibit the in vitro growth of two of the most common pathogens causing orthopaedic implant-related infections, Staphylococcus aureus and Pseudomonas aeruginosa, have been evaluated. Preliminary biocompatibility data arising from MG63 osteoblast-like cells seeding on the ciprofloxacin-loaded systems have also been discussed. The investigated system represents a promising candidate in view of the development of new antibiotic carriers in situ for preventing titanium implant-associated infections. |
| first_indexed | 2024-03-11T21:45:28Z |
| format | Article |
| id | doaj.art-540f627cc2f3488aab528597ca850542 |
| institution | Directory Open Access Journal |
| issn | 2150-5578 |
| language | English |
| last_indexed | 2024-03-11T21:45:28Z |
| publishDate | 2012-12-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Nano Biomedicine and Engineering |
| spelling | doaj.art-540f627cc2f3488aab528597ca8505422023-09-26T10:12:43ZengTsinghua University PressNano Biomedicine and Engineering2150-55782012-12-014416316910.5101/nbe.v4i4.p163-169Ciprofloxacin-loaded Chitosan Nanoparticles as Titanium Coatings: A Valuable Strategy to Prevent Implant-associated InfectionsElvira De Giglio0Adriana Trapani1Damiana Cafagna2Concetta Ferretti3Roberta Iatta4Stefania Cometa5Edmondo Ceci6Antonella Romanelli7Monica Mattioli-Belmonte8Dept. of Chemistry, University of BariAldo Moro,Bari,ItalyDept. of Pharmacy, University of BariAldo Moro,Bari,ItalyDept. of Chemistry, University of BariAldo Moro,Bari,ItalyDept. of Clinical and Molecular Sciences, UniversitàPolitecnicadelle Marche, Ancona, ItalyDept. of Biomedical Sciences and Human Oncology, University of BariAldo Moro, Bari, ItalyBIOLab, Chemistry & Industrial Chemistry Department, University of Pisa, Pisa, ItalyDepartment of Public Health, University of Bari Aldo Moro, Bari, ItalyDept. of Chemistry, University of BariAldo Moro,Bari,ItalyDept. of Clinical and Molecular Sciences, UniversitàPolitecnicadelle Marche, Ancona, ItalyOrthopaedic infections represent one of the major causes of implant failure. Systemic treatment is limited due to dosing, side-effects, patient compliance, treatment length and resistant bacteria. The choice of antibiotic incorporation method has been the subject of many investigations and, nowadays, various vehicles for local drug delivery have been studied. In this work, a novel ciprofloxacin loaded chitosan nanoparticles coating system onto titanium surface has been developed and characterized. The antibiotic release capability of this system and its ability to inhibit the in vitro growth of two of the most common pathogens causing orthopaedic implant-related infections, Staphylococcus aureus and Pseudomonas aeruginosa, have been evaluated. Preliminary biocompatibility data arising from MG63 osteoblast-like cells seeding on the ciprofloxacin-loaded systems have also been discussed. The investigated system represents a promising candidate in view of the development of new antibiotic carriers in situ for preventing titanium implant-associated infections.https://www.sciopen.com/article/10.5101/nbe.v4i4.p163-169infectiontitaniumchitosan nanoparticlesciprofloxacindrug releaseosteoblast |
| spellingShingle | Elvira De Giglio Adriana Trapani Damiana Cafagna Concetta Ferretti Roberta Iatta Stefania Cometa Edmondo Ceci Antonella Romanelli Monica Mattioli-Belmonte Ciprofloxacin-loaded Chitosan Nanoparticles as Titanium Coatings: A Valuable Strategy to Prevent Implant-associated Infections Nano Biomedicine and Engineering infection titanium chitosan nanoparticles ciprofloxacin drug release osteoblast |
| title | Ciprofloxacin-loaded Chitosan Nanoparticles as Titanium Coatings: A Valuable Strategy to Prevent Implant-associated Infections |
| title_full | Ciprofloxacin-loaded Chitosan Nanoparticles as Titanium Coatings: A Valuable Strategy to Prevent Implant-associated Infections |
| title_fullStr | Ciprofloxacin-loaded Chitosan Nanoparticles as Titanium Coatings: A Valuable Strategy to Prevent Implant-associated Infections |
| title_full_unstemmed | Ciprofloxacin-loaded Chitosan Nanoparticles as Titanium Coatings: A Valuable Strategy to Prevent Implant-associated Infections |
| title_short | Ciprofloxacin-loaded Chitosan Nanoparticles as Titanium Coatings: A Valuable Strategy to Prevent Implant-associated Infections |
| title_sort | ciprofloxacin loaded chitosan nanoparticles as titanium coatings a valuable strategy to prevent implant associated infections |
| topic | infection titanium chitosan nanoparticles ciprofloxacin drug release osteoblast |
| url | https://www.sciopen.com/article/10.5101/nbe.v4i4.p163-169 |
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