Probiotic Consortium Confers Synergistic Anti-Inflammatory Effects in Inflammatory Disorders
The composition and diversity of gut microbiota significantly influence the immune system and are linked to various diseases, including inflammatory and allergy disorders. While considerable research has focused on exploring single bacterial species or consortia, the optimal strategies for microbiot...
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MDPI AG
2024-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/16/6/790 |
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| author | Changhon Lee Seung Won Kim Ravi Verma Jaegyun Noh John Chulhoon Park Sunhee Park Haena Lee Hye Eun Park Chan Johng Kim Seohyun Byun Haeun Ko Seungyeon Choi Inhae Kim Soomin Jeon Junglyoul Lee Sin-Hyeog Im |
| author_facet | Changhon Lee Seung Won Kim Ravi Verma Jaegyun Noh John Chulhoon Park Sunhee Park Haena Lee Hye Eun Park Chan Johng Kim Seohyun Byun Haeun Ko Seungyeon Choi Inhae Kim Soomin Jeon Junglyoul Lee Sin-Hyeog Im |
| author_sort | Changhon Lee |
| collection | DOAJ |
| description | The composition and diversity of gut microbiota significantly influence the immune system and are linked to various diseases, including inflammatory and allergy disorders. While considerable research has focused on exploring single bacterial species or consortia, the optimal strategies for microbiota-based therapeutics remain underexplored. Specifically, the comparative effectiveness of bacterial consortia versus individual species warrants further investigation. In our study, we assessed the impact of the bacterial consortium MPRO, comprising <i>Lactiplantibacillus plantarum</i> HY7712, <i>Bifidobacterium animalis ssp. lactis</i> HY8002, and <i>Lacticaseibacillus casei</i> HY2782, in comparison to its individual components. The administration of MPRO demonstrated enhanced therapeutic efficacy in experimental models of atopic dermatitis and inflammatory colitis when compared to single strains. MPRO exhibited the ability to dampen inflammatory responses and alter the gut microbial landscape significantly. Notably, MPRO administration led to an increase in intestinal CD103<sup>+</sup>CD11b<sup>+</sup> dendritic cells, promoting the induction of regulatory T cells and the robust suppression of inflammation in experimental disease settings. Our findings advocate the preference for bacterial consortia over single strains in the treatment of inflammatory disorders, carrying potential clinical relevance. |
| first_indexed | 2024-04-24T17:57:10Z |
| format | Article |
| id | doaj.art-540fbc8b39064062b0980370cdc9d850 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-04-24T17:57:10Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-540fbc8b39064062b0980370cdc9d8502024-03-27T13:58:06ZengMDPI AGNutrients2072-66432024-03-0116679010.3390/nu16060790Probiotic Consortium Confers Synergistic Anti-Inflammatory Effects in Inflammatory DisordersChanghon Lee0Seung Won Kim1Ravi Verma2Jaegyun Noh3John Chulhoon Park4Sunhee Park5Haena Lee6Hye Eun Park7Chan Johng Kim8Seohyun Byun9Haeun Ko10Seungyeon Choi11Inhae Kim12Soomin Jeon13Junglyoul Lee14Sin-Hyeog Im15Department of Life Sciences, POSTECH Biotech Center, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of KoreaDepartment of Life Sciences, POSTECH Biotech Center, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of KoreaImmmunoBiome Inc., 77 Cheongam-ro, Nam-gu, Pohang 37673, Republic of KoreaDepartment of Life Sciences, POSTECH Biotech Center, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of KoreaDepartment of Life Sciences, POSTECH Biotech Center, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of KoreaImmmunoBiome Inc., 77 Cheongam-ro, Nam-gu, Pohang 37673, Republic of KoreaDepartment of Life Sciences, POSTECH Biotech Center, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of KoreaDepartment of Life Sciences, POSTECH Biotech Center, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of KoreaDepartment of Life Sciences, POSTECH Biotech Center, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of KoreaDepartment of Life Sciences, POSTECH Biotech Center, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of KoreaDepartment of Life Sciences, POSTECH Biotech Center, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of KoreaImmmunoBiome Inc., 77 Cheongam-ro, Nam-gu, Pohang 37673, Republic of KoreaImmmunoBiome Inc., 77 Cheongam-ro, Nam-gu, Pohang 37673, Republic of Koreahy Co., Ltd., 22 Giheungdanji-ro 24 beon-gil, Giheung-gu, Yongin 17086, Republic of Koreahy Co., Ltd., 22 Giheungdanji-ro 24 beon-gil, Giheung-gu, Yongin 17086, Republic of KoreaDepartment of Life Sciences, POSTECH Biotech Center, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of KoreaThe composition and diversity of gut microbiota significantly influence the immune system and are linked to various diseases, including inflammatory and allergy disorders. While considerable research has focused on exploring single bacterial species or consortia, the optimal strategies for microbiota-based therapeutics remain underexplored. Specifically, the comparative effectiveness of bacterial consortia versus individual species warrants further investigation. In our study, we assessed the impact of the bacterial consortium MPRO, comprising <i>Lactiplantibacillus plantarum</i> HY7712, <i>Bifidobacterium animalis ssp. lactis</i> HY8002, and <i>Lacticaseibacillus casei</i> HY2782, in comparison to its individual components. The administration of MPRO demonstrated enhanced therapeutic efficacy in experimental models of atopic dermatitis and inflammatory colitis when compared to single strains. MPRO exhibited the ability to dampen inflammatory responses and alter the gut microbial landscape significantly. Notably, MPRO administration led to an increase in intestinal CD103<sup>+</sup>CD11b<sup>+</sup> dendritic cells, promoting the induction of regulatory T cells and the robust suppression of inflammation in experimental disease settings. Our findings advocate the preference for bacterial consortia over single strains in the treatment of inflammatory disorders, carrying potential clinical relevance.https://www.mdpi.com/2072-6643/16/6/790probiotic consortiummicrobiotaatopic dermatitisregulatory T cellinflammatory colitis |
| spellingShingle | Changhon Lee Seung Won Kim Ravi Verma Jaegyun Noh John Chulhoon Park Sunhee Park Haena Lee Hye Eun Park Chan Johng Kim Seohyun Byun Haeun Ko Seungyeon Choi Inhae Kim Soomin Jeon Junglyoul Lee Sin-Hyeog Im Probiotic Consortium Confers Synergistic Anti-Inflammatory Effects in Inflammatory Disorders Nutrients probiotic consortium microbiota atopic dermatitis regulatory T cell inflammatory colitis |
| title | Probiotic Consortium Confers Synergistic Anti-Inflammatory Effects in Inflammatory Disorders |
| title_full | Probiotic Consortium Confers Synergistic Anti-Inflammatory Effects in Inflammatory Disorders |
| title_fullStr | Probiotic Consortium Confers Synergistic Anti-Inflammatory Effects in Inflammatory Disorders |
| title_full_unstemmed | Probiotic Consortium Confers Synergistic Anti-Inflammatory Effects in Inflammatory Disorders |
| title_short | Probiotic Consortium Confers Synergistic Anti-Inflammatory Effects in Inflammatory Disorders |
| title_sort | probiotic consortium confers synergistic anti inflammatory effects in inflammatory disorders |
| topic | probiotic consortium microbiota atopic dermatitis regulatory T cell inflammatory colitis |
| url | https://www.mdpi.com/2072-6643/16/6/790 |
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