Distinct changes in functional connectivity in posteromedial cortex subregions during the progress of Alzheimer’s disease
Alzheimer’s disease is a progressive neurodegenerative disorder which causes dementia, especially in the elderly. The posteromedial cortex, which consists of several subregions involved in distinct functions, is one of the critical regions associated with the progression and severity of Alzheimer’s...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-04-01
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| Series: | Frontiers in Neuroanatomy |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnana.2016.00041/full |
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| author | Yan eWu Yaqin eZhang Yong eLiu Yong eLiu Jieqiong eLiu Yunyun eDuan Xuehu eWei Junjie eZhuo Kuncheng eLi Xinqing eZhang Chunshui eYu Jiaojian eWang Tianzi eJiang Tianzi eJiang Tianzi eJiang Tianzi eJiang Tianzi eJiang |
| author_facet | Yan eWu Yaqin eZhang Yong eLiu Yong eLiu Jieqiong eLiu Yunyun eDuan Xuehu eWei Junjie eZhuo Kuncheng eLi Xinqing eZhang Chunshui eYu Jiaojian eWang Tianzi eJiang Tianzi eJiang Tianzi eJiang Tianzi eJiang Tianzi eJiang |
| author_sort | Yan eWu |
| collection | DOAJ |
| description | Alzheimer’s disease is a progressive neurodegenerative disorder which causes dementia, especially in the elderly. The posteromedial cortex, which consists of several subregions involved in distinct functions, is one of the critical regions associated with the progression and severity of Alzheimer’s disease. However, previous studies always ignored the heterogeneity of the posteromedial cortex and focused on one stage of Alzheimer’s disease. Using resting-state functional magnetic resonance imaging, we studied the respective alterations of each subregion within the posteromedial cortex along the progression of Alzheimer’s disease. Our data set consisted of 21 healthy controls, 18 patients with mild cognitive impairment, 17 patients with mild Alzheimer’s disease, and 18 patients with severe Alzheimer’s disease. We investigated the functional alterations of each subregion within the posteromedial cortex in different stages of Alzheimer’s disease. We found that subregions within the posteromedial cortex have differential vulnerability in Alzheimer’s disease. Disruptions in functional connectivity began in the transition area between the precuneus and the posterior cingulate cortex and then extended to other subregions of the posteromedial cortex. In addition, each of these subregions was associated with distinct alterations in the functional networks that we were able to relate to Alzheimer’s disease. Our research demonstrated functional changes within the posteromedial cortex in the progression of Alzheimer’s disease and may elucidate potential biomarkers for clinical applications. |
| first_indexed | 2024-12-24T04:11:12Z |
| format | Article |
| id | doaj.art-5410f6c6936e4ca9a77db2a681c91539 |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-12-24T04:11:12Z |
| publishDate | 2016-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-5410f6c6936e4ca9a77db2a681c915392022-12-21T17:16:03ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292016-04-011010.3389/fnana.2016.00041186735Distinct changes in functional connectivity in posteromedial cortex subregions during the progress of Alzheimer’s diseaseYan eWu0Yaqin eZhang1Yong eLiu2Yong eLiu3Jieqiong eLiu4Yunyun eDuan5Xuehu eWei6Junjie eZhuo7Kuncheng eLi8Xinqing eZhang9Chunshui eYu10Jiaojian eWang11Tianzi eJiang12Tianzi eJiang13Tianzi eJiang14Tianzi eJiang15Tianzi eJiang16University of Electronic Science and Technology of ChinaUniversity of Electronic Science and Technology of ChinaInstitute of Automation, Chinese Academy of SciencesChinese Academy of SciencesXuanwu Hospital of Capital Medical UniversityXuanwu Hospital of Capital Medical UniversityUniversity of Electronic Science and Technology of ChinaUniversity of Electronic Science and Technology of ChinaXuanwu Hospital of Capital Medical UniversityXuanwu Hospital of Capital Medical UniversityTianjin Medical University General HospitalUniversity of Electronic Science and Technology of ChinaUniversity of Electronic Science and Technology of ChinaInstitute of Automation, Chinese Academy of SciencesChinese Academy of SciencesInstitute of Automation, Chinese Academy of SciencesThe University of QueenslandAlzheimer’s disease is a progressive neurodegenerative disorder which causes dementia, especially in the elderly. The posteromedial cortex, which consists of several subregions involved in distinct functions, is one of the critical regions associated with the progression and severity of Alzheimer’s disease. However, previous studies always ignored the heterogeneity of the posteromedial cortex and focused on one stage of Alzheimer’s disease. Using resting-state functional magnetic resonance imaging, we studied the respective alterations of each subregion within the posteromedial cortex along the progression of Alzheimer’s disease. Our data set consisted of 21 healthy controls, 18 patients with mild cognitive impairment, 17 patients with mild Alzheimer’s disease, and 18 patients with severe Alzheimer’s disease. We investigated the functional alterations of each subregion within the posteromedial cortex in different stages of Alzheimer’s disease. We found that subregions within the posteromedial cortex have differential vulnerability in Alzheimer’s disease. Disruptions in functional connectivity began in the transition area between the precuneus and the posterior cingulate cortex and then extended to other subregions of the posteromedial cortex. In addition, each of these subregions was associated with distinct alterations in the functional networks that we were able to relate to Alzheimer’s disease. Our research demonstrated functional changes within the posteromedial cortex in the progression of Alzheimer’s disease and may elucidate potential biomarkers for clinical applications.http://journal.frontiersin.org/Journal/10.3389/fnana.2016.00041/fullnetworkfunctional connectivityAlzheimer’s diseaseSubregionsposteromedial cortex |
| spellingShingle | Yan eWu Yaqin eZhang Yong eLiu Yong eLiu Jieqiong eLiu Yunyun eDuan Xuehu eWei Junjie eZhuo Kuncheng eLi Xinqing eZhang Chunshui eYu Jiaojian eWang Tianzi eJiang Tianzi eJiang Tianzi eJiang Tianzi eJiang Tianzi eJiang Distinct changes in functional connectivity in posteromedial cortex subregions during the progress of Alzheimer’s disease Frontiers in Neuroanatomy network functional connectivity Alzheimer’s disease Subregions posteromedial cortex |
| title | Distinct changes in functional connectivity in posteromedial cortex subregions during the progress of Alzheimer’s disease |
| title_full | Distinct changes in functional connectivity in posteromedial cortex subregions during the progress of Alzheimer’s disease |
| title_fullStr | Distinct changes in functional connectivity in posteromedial cortex subregions during the progress of Alzheimer’s disease |
| title_full_unstemmed | Distinct changes in functional connectivity in posteromedial cortex subregions during the progress of Alzheimer’s disease |
| title_short | Distinct changes in functional connectivity in posteromedial cortex subregions during the progress of Alzheimer’s disease |
| title_sort | distinct changes in functional connectivity in posteromedial cortex subregions during the progress of alzheimer s disease |
| topic | network functional connectivity Alzheimer’s disease Subregions posteromedial cortex |
| url | http://journal.frontiersin.org/Journal/10.3389/fnana.2016.00041/full |
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