Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis

Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis

Objective: Aberrant ketogenesis is correlated with the degree of steatosis in non-alcoholic fatty liver disease (NAFLD) patients, and an inborn error of ketogenesis (mitochondrial HMG-CoA synthase deficiency) is commonly associated with the development of the fatty liver. Here we aimed to determine...

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Bibliographic Details
Main Authors: Shaza Asif, Ri Youn Kim, Thet Fatica, Jordan Sim, Xiaoling Zhao, Yena Oh, Alix Denoncourt, Angela C. Cheung, Michael Downey, Erin E. Mulvihill, Kyoung-Han Kim
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Molecular Metabolism
Subjects:
Ketogenesis
Hmgcs2
NAFLD
Lipid accumulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822000631

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