Flavonoids and ischemic stroke-induced neuroinflammation: Focus on the glial cells
Ischemic stroke is one of the most cases worldwide, with high rate of morbidity and mortality. In the pathological process of ischemic stroke, neuroinflammation is an essential process that defines the functional prognosis. After stroke onset, microglia, astrocytes and the infiltrating immune cells...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223016451 |
| _version_ | 1797364292850286592 |
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| author | Weizhuo Lu Zhiwu Chen Jiyue Wen |
| author_facet | Weizhuo Lu Zhiwu Chen Jiyue Wen |
| author_sort | Weizhuo Lu |
| collection | DOAJ |
| description | Ischemic stroke is one of the most cases worldwide, with high rate of morbidity and mortality. In the pathological process of ischemic stroke, neuroinflammation is an essential process that defines the functional prognosis. After stroke onset, microglia, astrocytes and the infiltrating immune cells contribute to a complicated neuroinflammation cascade and play the complicated roles in the pathophysiological variations of ischemic stroke. Both microglia and astrocytes undergo both morphological and functional changes, thereby deeply participate in the neuronal inflammation via releasing pro-inflammatory or anti-inflammatory factors. Flavonoids are plant-specific secondary metabolites and can protect against cerebral ischemia injury via modulating the inflammatory responses. For instances, quercetin can inhibit the expression and release of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α, IL-6 and IL-1β, in the cerebral nervous system (CNS). Apigenin and rutin can promote the polarization of microglia to anti-inflammatory genotype and then inhibit neuroinflammation. In this review, we focused on the dual roles of activated microglia and reactive astrocyte in the neuroinflammation following ischemic stroke and discussed the anti-neuroinflammation of some flavonoids. Importantly, we aimed to reveal the new strategies for alleviating the cerebral ischemic stroke. |
| first_indexed | 2024-03-08T16:33:11Z |
| format | Article |
| id | doaj.art-5413e43e5f6a4d749a73a4075cae1829 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-08T16:33:11Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-5413e43e5f6a4d749a73a4075cae18292024-01-06T04:37:34ZengElsevierBiomedicine & Pharmacotherapy0753-33222024-01-01170115847Flavonoids and ischemic stroke-induced neuroinflammation: Focus on the glial cellsWeizhuo Lu0Zhiwu Chen1Jiyue Wen2Medical Branch, Hefei Technology College, Hefei, ChinaDepartment of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China; Corresponding authors.Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China; Corresponding authors.Ischemic stroke is one of the most cases worldwide, with high rate of morbidity and mortality. In the pathological process of ischemic stroke, neuroinflammation is an essential process that defines the functional prognosis. After stroke onset, microglia, astrocytes and the infiltrating immune cells contribute to a complicated neuroinflammation cascade and play the complicated roles in the pathophysiological variations of ischemic stroke. Both microglia and astrocytes undergo both morphological and functional changes, thereby deeply participate in the neuronal inflammation via releasing pro-inflammatory or anti-inflammatory factors. Flavonoids are plant-specific secondary metabolites and can protect against cerebral ischemia injury via modulating the inflammatory responses. For instances, quercetin can inhibit the expression and release of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α, IL-6 and IL-1β, in the cerebral nervous system (CNS). Apigenin and rutin can promote the polarization of microglia to anti-inflammatory genotype and then inhibit neuroinflammation. In this review, we focused on the dual roles of activated microglia and reactive astrocyte in the neuroinflammation following ischemic stroke and discussed the anti-neuroinflammation of some flavonoids. Importantly, we aimed to reveal the new strategies for alleviating the cerebral ischemic stroke.http://www.sciencedirect.com/science/article/pii/S0753332223016451MicrogliaAstrocyteNeuroinflammationIschemic strokeFlavonoids |
| spellingShingle | Weizhuo Lu Zhiwu Chen Jiyue Wen Flavonoids and ischemic stroke-induced neuroinflammation: Focus on the glial cells Biomedicine & Pharmacotherapy Microglia Astrocyte Neuroinflammation Ischemic stroke Flavonoids |
| title | Flavonoids and ischemic stroke-induced neuroinflammation: Focus on the glial cells |
| title_full | Flavonoids and ischemic stroke-induced neuroinflammation: Focus on the glial cells |
| title_fullStr | Flavonoids and ischemic stroke-induced neuroinflammation: Focus on the glial cells |
| title_full_unstemmed | Flavonoids and ischemic stroke-induced neuroinflammation: Focus on the glial cells |
| title_short | Flavonoids and ischemic stroke-induced neuroinflammation: Focus on the glial cells |
| title_sort | flavonoids and ischemic stroke induced neuroinflammation focus on the glial cells |
| topic | Microglia Astrocyte Neuroinflammation Ischemic stroke Flavonoids |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223016451 |
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