Inhibition of xanthine oxidase by allopurinol suppresses HMGB1 secretion and ameliorates experimental asthma

Inhibition of xanthine oxidase by allopurinol suppresses HMGB1 secretion and ameliorates experimental asthma

Background: Extracellular high mobility group box 1 (HMGB1) is a key mediator in driving allergic airway inflammation and contributes to asthma. Yet, mechanism of HMGB1 secretion in asthma is poorly defined. Pulmonary metabolic dysfunction is recently recognized as a driver of respiratory pathology....

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Bibliographic Details
Main Authors: Yanhong Wang, Yanqing Le, Jie Wu, Wenqu Zhao, Qian Zhang, Guiling Xu, Zhaoqian Gong, Maosheng Xu, Yanyan Ma, Changhui Yu, Shaoxi Cai, Haijin Zhao
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Redox Biology
Subjects:
Allopurinol
Asthma
HMGB1
Purine metabolism
SIRT1
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723004226

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