Prevalence of prediabetes and undiagnosed diabetes in a large urban middle-aged population: the CARVAR 92 cohort
Abstract Background The aim of this study was to assess the prevalence of prediabetes and unknown diabetes and its long-term change in a large middle-aged urban population. Methods We conducted a screening campaign between 2007 and 2018 for cardiovascular risk factors in the western suburbs of Paris...
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12933-023-01761-3 |
| _version_ | 1797865602136670208 |
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| author | Marie Hauguel-Moreau Hélène Hergault Laure Cazabat Marion Pépin Alain Beauchet Vincent Aïdan Mounir Ouadahi Loïc Josseran Mirella Hage Christophe Rodon Olivier Dubourg Ziad Massy Nicolas Mansencal |
| author_facet | Marie Hauguel-Moreau Hélène Hergault Laure Cazabat Marion Pépin Alain Beauchet Vincent Aïdan Mounir Ouadahi Loïc Josseran Mirella Hage Christophe Rodon Olivier Dubourg Ziad Massy Nicolas Mansencal |
| author_sort | Marie Hauguel-Moreau |
| collection | DOAJ |
| description | Abstract Background The aim of this study was to assess the prevalence of prediabetes and unknown diabetes and its long-term change in a large middle-aged urban population. Methods We conducted a screening campaign between 2007 and 2018 for cardiovascular risk factors in the western suburbs of Paris including subjects aged 40–70 (CARVAR 92). Among subjects who reported no previous diabetes, prediabetes and undiagnosed diabetes were defined as follows: fasting plasma glucose (FPG) ≥ 6.1 mmol/l (110 mg/dl) and < 7 mmol/l (126 mg/dl) for prediabetes according to WHO criteria (FPG between 5.6 and 6.9 mmol/l according to ADA criteria) and FPG ≥ 7.0 mmol/l for undiagnosed diabetes. Results Of the 32,721 subjects in the CARVAR 92 cohort, 32,675 were included in this analysis. The median age of the patients was 56 years [30, 94], 45.4% were male, 5.9% had known diabetes, 36.4% were overweight and 18.7% obese. Among patients without previously known diabetes (n = 30,759), 8.1% had prediabetes according to WHO criteria (27.2% according to ADA criteria) and 2.3% had diabetes. Subjects with prediabetes and unknown diabetes were more likely to be male, older, and overweight or obese than non-diabetic subjects. From 2007 to 2018, the prevalence of prediabetes, unknown diabetes, and known diabetes decreased, except for prediabetes which remained stable for people aged 55–64. Conclusion The prevalence of prediabetes and unknown diabetes remains high but decreased during a 12-year period. About one-quarter of diabetes cases remain undiagnosed. Our results highlight that there is still a room for screening and cardiovascular prevention campaigns. Trial registration: IRB00012437. |
| first_indexed | 2024-04-09T23:11:52Z |
| format | Article |
| id | doaj.art-5414b6ddb7574ed9b0ef5d9b38b97a66 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-04-09T23:11:52Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-5414b6ddb7574ed9b0ef5d9b38b97a662023-03-22T10:21:03ZengBMCCardiovascular Diabetology1475-28402023-02-012211810.1186/s12933-023-01761-3Prevalence of prediabetes and undiagnosed diabetes in a large urban middle-aged population: the CARVAR 92 cohortMarie Hauguel-Moreau0Hélène Hergault1Laure Cazabat2Marion Pépin3Alain Beauchet4Vincent Aïdan5Mounir Ouadahi6Loïc Josseran7Mirella Hage8Christophe Rodon9Olivier Dubourg10Ziad Massy11Nicolas Mansencal12Department of Cardiology, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Centre de Référence Des Cardiomyopathies Et Des Troubles du Rythme Cardiaque Héréditaires Ou Rares, Université de Versailles-Saint Quentin (UVSQ), ACTION Study Group, ParisDepartment of Cardiology, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Centre de Référence Des Cardiomyopathies Et Des Troubles du Rythme Cardiaque Héréditaires Ou Rares, Université de Versailles-Saint Quentin (UVSQ), ACTION Study Group, ParisDepartment of Endocrinology, Diabetology and Nutrition, Ambroise Paré Hospital, AP-HP, UVSQINSERM U-1018, CESP, Épidémiologie clinique, UVSQPublic Health Department, APHP, UVSQDepartment of Cardiology, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Centre de Référence Des Cardiomyopathies Et Des Troubles du Rythme Cardiaque Héréditaires Ou Rares, Université de Versailles-Saint Quentin (UVSQ), ACTION Study Group, ParisDepartment of Cardiology, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Centre de Référence Des Cardiomyopathies Et Des Troubles du Rythme Cardiaque Héréditaires Ou Rares, Université de Versailles-Saint Quentin (UVSQ), ACTION Study Group, ParisDépartement Hospitalier d’Epidémiologie et de Santé Publique, AP-HP, GHU Paris Saclay, Hôpital Raymond-PoincaréDepartment of Endocrinology, Diabetology and Nutrition, Ambroise Paré Hospital, AP-HP, UVSQLocal Health insurance, Hauts de Seine DepartmentDepartment of Cardiology, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Centre de Référence Des Cardiomyopathies Et Des Troubles du Rythme Cardiaque Héréditaires Ou Rares, Université de Versailles-Saint Quentin (UVSQ), ACTION Study Group, ParisINSERM U-1018, CESP, Épidémiologie clinique, UVSQDepartment of Cardiology, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Centre de Référence Des Cardiomyopathies Et Des Troubles du Rythme Cardiaque Héréditaires Ou Rares, Université de Versailles-Saint Quentin (UVSQ), ACTION Study Group, ParisAbstract Background The aim of this study was to assess the prevalence of prediabetes and unknown diabetes and its long-term change in a large middle-aged urban population. Methods We conducted a screening campaign between 2007 and 2018 for cardiovascular risk factors in the western suburbs of Paris including subjects aged 40–70 (CARVAR 92). Among subjects who reported no previous diabetes, prediabetes and undiagnosed diabetes were defined as follows: fasting plasma glucose (FPG) ≥ 6.1 mmol/l (110 mg/dl) and < 7 mmol/l (126 mg/dl) for prediabetes according to WHO criteria (FPG between 5.6 and 6.9 mmol/l according to ADA criteria) and FPG ≥ 7.0 mmol/l for undiagnosed diabetes. Results Of the 32,721 subjects in the CARVAR 92 cohort, 32,675 were included in this analysis. The median age of the patients was 56 years [30, 94], 45.4% were male, 5.9% had known diabetes, 36.4% were overweight and 18.7% obese. Among patients without previously known diabetes (n = 30,759), 8.1% had prediabetes according to WHO criteria (27.2% according to ADA criteria) and 2.3% had diabetes. Subjects with prediabetes and unknown diabetes were more likely to be male, older, and overweight or obese than non-diabetic subjects. From 2007 to 2018, the prevalence of prediabetes, unknown diabetes, and known diabetes decreased, except for prediabetes which remained stable for people aged 55–64. Conclusion The prevalence of prediabetes and unknown diabetes remains high but decreased during a 12-year period. About one-quarter of diabetes cases remain undiagnosed. Our results highlight that there is still a room for screening and cardiovascular prevention campaigns. Trial registration: IRB00012437.https://doi.org/10.1186/s12933-023-01761-3PrediabetesUnknown diabetesPrevalencePrimary prevention |
| spellingShingle | Marie Hauguel-Moreau Hélène Hergault Laure Cazabat Marion Pépin Alain Beauchet Vincent Aïdan Mounir Ouadahi Loïc Josseran Mirella Hage Christophe Rodon Olivier Dubourg Ziad Massy Nicolas Mansencal Prevalence of prediabetes and undiagnosed diabetes in a large urban middle-aged population: the CARVAR 92 cohort Cardiovascular Diabetology Prediabetes Unknown diabetes Prevalence Primary prevention |
| title | Prevalence of prediabetes and undiagnosed diabetes in a large urban middle-aged population: the CARVAR 92 cohort |
| title_full | Prevalence of prediabetes and undiagnosed diabetes in a large urban middle-aged population: the CARVAR 92 cohort |
| title_fullStr | Prevalence of prediabetes and undiagnosed diabetes in a large urban middle-aged population: the CARVAR 92 cohort |
| title_full_unstemmed | Prevalence of prediabetes and undiagnosed diabetes in a large urban middle-aged population: the CARVAR 92 cohort |
| title_short | Prevalence of prediabetes and undiagnosed diabetes in a large urban middle-aged population: the CARVAR 92 cohort |
| title_sort | prevalence of prediabetes and undiagnosed diabetes in a large urban middle aged population the carvar 92 cohort |
| topic | Prediabetes Unknown diabetes Prevalence Primary prevention |
| url | https://doi.org/10.1186/s12933-023-01761-3 |
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