SARS-CoV-2 S protein activates NLRP3 inflammasome and deregulates coagulation factors in endothelial and immune cells

SARS-CoV-2 S protein activates NLRP3 inflammasome and deregulates coagulation factors in endothelial and immune cells

Abstract Background Hyperinflammation, hypercoagulation and endothelial injury are major findings in acute and post-COVID-19. The SARS-CoV-2 S protein has been detected as an isolated element in human tissues reservoirs and is the main product of mRNA COVID-19 vaccines. We investigated whether the S...

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Bibliographic Details
Main Authors: Alicia Villacampa, Enrique Alfaro, Cristina Morales, Elena Díaz-García, Cristina López-Fernández, José Luis Bartha, Francisco López-Sánchez, Óscar Lorenzo, Salvador Moncada, Carlos F. Sánchez-Ferrer, Francisco García-Río, Carolina Cubillos-Zapata, Concepción Peiró
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Cell Communication and Signaling
Subjects:
Blood coagulation factors
SARS-CoV-2
Endothelial cells
NLRP3 inflammasome
Monocytes
Online Access:https://doi.org/10.1186/s12964-023-01397-6

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