The Role of Curcumin in Cancer Treatment
Curcumin is a polyphenol extracted from the rhizomes of the turmeric plant, <i>Curcuma longa</i> which has anti-inflammatory, and anticancer properties. Chronic inflammation is associated with the development of cancer. Curcumin acts on the regulation of various immune modulators, includ...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/9/1086 |
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| author | Vasiliki Zoi Vasiliki Galani Georgios D. Lianos Spyridon Voulgaris Athanasios P. Kyritsis George A. Alexiou |
| author_facet | Vasiliki Zoi Vasiliki Galani Georgios D. Lianos Spyridon Voulgaris Athanasios P. Kyritsis George A. Alexiou |
| author_sort | Vasiliki Zoi |
| collection | DOAJ |
| description | Curcumin is a polyphenol extracted from the rhizomes of the turmeric plant, <i>Curcuma longa</i> which has anti-inflammatory, and anticancer properties. Chronic inflammation is associated with the development of cancer. Curcumin acts on the regulation of various immune modulators, including cytokines, cyclooxygenase-2 (COX-2), and reactive oxygen species (ROS), which partly explains its anticancer effects. It also takes part in the downregulation of growth factors, protein kinases, oncogenic molecules and various signaling pathways, such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), c-Jun N-terminal kinase (JNK) and signal transducer and activator of transcription 3 (STAT3) signaling. Clinical trials of curcumin have been completed or are ongoing for various types of cancer. This review presents the molecular mechanisms of curcumin in different types of cancer and the evidence from the most recent clinical trials. |
| first_indexed | 2024-03-10T07:53:10Z |
| format | Article |
| id | doaj.art-5416d30b42ef411d8d2c40fd14829509 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T07:53:10Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-5416d30b42ef411d8d2c40fd148295092023-11-22T12:06:47ZengMDPI AGBiomedicines2227-90592021-08-0199108610.3390/biomedicines9091086The Role of Curcumin in Cancer TreatmentVasiliki Zoi0Vasiliki Galani1Georgios D. Lianos2Spyridon Voulgaris3Athanasios P. Kyritsis4George A. Alexiou5Neurosurgical Institute, School of Medicine, University of Ioannina, 45500 Ioannina, GreeceDepartment of Anatomy Histology-Embryology, School of Medicine, University of Ioannina, 45500 Ioannina, GreeceDepartment of Surgery, University Hospital of Ioannina, 45500 Ioannina, GreeceNeurosurgical Institute, School of Medicine, University of Ioannina, 45500 Ioannina, GreeceNeurosurgical Institute, School of Medicine, University of Ioannina, 45500 Ioannina, GreeceNeurosurgical Institute, School of Medicine, University of Ioannina, 45500 Ioannina, GreeceCurcumin is a polyphenol extracted from the rhizomes of the turmeric plant, <i>Curcuma longa</i> which has anti-inflammatory, and anticancer properties. Chronic inflammation is associated with the development of cancer. Curcumin acts on the regulation of various immune modulators, including cytokines, cyclooxygenase-2 (COX-2), and reactive oxygen species (ROS), which partly explains its anticancer effects. It also takes part in the downregulation of growth factors, protein kinases, oncogenic molecules and various signaling pathways, such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), c-Jun N-terminal kinase (JNK) and signal transducer and activator of transcription 3 (STAT3) signaling. Clinical trials of curcumin have been completed or are ongoing for various types of cancer. This review presents the molecular mechanisms of curcumin in different types of cancer and the evidence from the most recent clinical trials.https://www.mdpi.com/2227-9059/9/9/1086curcumincancercell signaling pathways |
| spellingShingle | Vasiliki Zoi Vasiliki Galani Georgios D. Lianos Spyridon Voulgaris Athanasios P. Kyritsis George A. Alexiou The Role of Curcumin in Cancer Treatment Biomedicines curcumin cancer cell signaling pathways |
| title | The Role of Curcumin in Cancer Treatment |
| title_full | The Role of Curcumin in Cancer Treatment |
| title_fullStr | The Role of Curcumin in Cancer Treatment |
| title_full_unstemmed | The Role of Curcumin in Cancer Treatment |
| title_short | The Role of Curcumin in Cancer Treatment |
| title_sort | role of curcumin in cancer treatment |
| topic | curcumin cancer cell signaling pathways |
| url | https://www.mdpi.com/2227-9059/9/9/1086 |
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