ADS024, a Bacillus velezensis strain, protects human colonic epithelial cells against C. difficile toxin-mediated apoptosis

ADS024, a Bacillus velezensis strain, protects human colonic epithelial cells against C. difficile toxin-mediated apoptosis

Clostridioides difficile infection (CDI) causes intestinal injury. Toxin A and toxin B cause intestinal injury by inducing colonic epithelial cell apoptosis. ADS024 is a Bacillus velezensis strain in development as a single-strain live biotherapeutic product (SS-LBP) to prevent the recurrence of CDI...

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Bibliographic Details
Main Authors: Ying Xie, Andrea Chupina Estrada, Becca Nelson, Hanping Feng, Charalabos Pothoulakis, Laurent Chesnel, Hon Wai Koon
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Microbiology
Subjects:
infection
biologic
therapy
single-strain live biotherapeutic product
apoptosis
C. difficile
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.1072534/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.1072534/full

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