Comparison of Seroflu and Seretide Inhalers on Spirometry Criteria and Clinical Symptoms in Patients with Severe and Moderate Asthma
Background and purpose: Asthma is one of the most prevalent chronic respiratory diseases which has become more prevalent over the past three decades. Seroflo and Seretide are inhalers that contain fluticasone (an anti-inflammatory corticosteroid) and salmeterol (a long-acting bronchodilator). This s...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2023-03-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-18560-en.pdf |
| _version_ | 1827698695791968256 |
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| author | Hamidreza Houshmand Reza Ghaemi Mohammad Alavi Gholamreza Houshmand |
| author_facet | Hamidreza Houshmand Reza Ghaemi Mohammad Alavi Gholamreza Houshmand |
| author_sort | Hamidreza Houshmand |
| collection | DOAJ |
| description | Background and purpose: Asthma is one of the most prevalent chronic respiratory diseases which has become more prevalent over the past three decades. Seroflo and Seretide are inhalers that contain fluticasone (an anti-inflammatory corticosteroid) and salmeterol (a long-acting bronchodilator). This study aimed to compare the effects of Seroflo and Seretide nasal sprays on spirometry criteria and clinical symptoms in pediatric patients with moderate to severe asthma.
Materials and methods: A retrospective study was performed using the medical records of 42 patients aged 6-15 years with a history of moderate-to-severe persistent asthma who were treated with Seroflo (group A)and Seretide (group B) inhalers in Shahid Motahari Hospital (affiliated with Urmia University of Medical Sciences). Data, including age, gender, clinical symptoms (coughs and shortness of breath), and spirometry variables were documented in pre-made checklists. Data analysis was carried out in SPSS V22.
Results: Changes in PEF and FEV1 (parameters of treatment responses) were statistically significant in both groups (P<0.05), but no significant differences were observed in these parameters between the two groups (P>0.05). In this study, treatment with Seroflo caused more significant relief in clinical symptoms, including coughs, intermittent shortness of breath, daily attacks, and wheezing compared to Seretide after one and three months of treatment (P<0.05).
Conclusion: This study suggested that Seroflo and Seretide inhalers improved the spirometry indices to a similar degree, but treatment with Seroflo relieved the patients’ clinical symptoms more than Seretide. |
| first_indexed | 2024-03-10T13:33:48Z |
| format | Article |
| id | doaj.art-54194b6b1b8a438ba7ff20b915f2a1e7 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-03-10T13:33:48Z |
| publishDate | 2023-03-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-54194b6b1b8a438ba7ff20b915f2a1e72023-11-21T07:40:31ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792023-03-01322182230Comparison of Seroflu and Seretide Inhalers on Spirometry Criteria and Clinical Symptoms in Patients with Severe and Moderate AsthmaHamidreza Houshmand0Reza Ghaemi1Mohammad Alavi2Gholamreza Houshmand3 Assistant Professor, Department of Pediatrics, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran Assistant Professor, Department of Pediatrics, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran Medical Doctor, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran Assitant Professor, Immunogenetics Research Center, Department of Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Background and purpose: Asthma is one of the most prevalent chronic respiratory diseases which has become more prevalent over the past three decades. Seroflo and Seretide are inhalers that contain fluticasone (an anti-inflammatory corticosteroid) and salmeterol (a long-acting bronchodilator). This study aimed to compare the effects of Seroflo and Seretide nasal sprays on spirometry criteria and clinical symptoms in pediatric patients with moderate to severe asthma. Materials and methods: A retrospective study was performed using the medical records of 42 patients aged 6-15 years with a history of moderate-to-severe persistent asthma who were treated with Seroflo (group A)and Seretide (group B) inhalers in Shahid Motahari Hospital (affiliated with Urmia University of Medical Sciences). Data, including age, gender, clinical symptoms (coughs and shortness of breath), and spirometry variables were documented in pre-made checklists. Data analysis was carried out in SPSS V22. Results: Changes in PEF and FEV1 (parameters of treatment responses) were statistically significant in both groups (P<0.05), but no significant differences were observed in these parameters between the two groups (P>0.05). In this study, treatment with Seroflo caused more significant relief in clinical symptoms, including coughs, intermittent shortness of breath, daily attacks, and wheezing compared to Seretide after one and three months of treatment (P<0.05). Conclusion: This study suggested that Seroflo and Seretide inhalers improved the spirometry indices to a similar degree, but treatment with Seroflo relieved the patients’ clinical symptoms more than Seretide.http://jmums.mazums.ac.ir/article-1-18560-en.pdfasthmaserofloseretidespirometrychildren |
| spellingShingle | Hamidreza Houshmand Reza Ghaemi Mohammad Alavi Gholamreza Houshmand Comparison of Seroflu and Seretide Inhalers on Spirometry Criteria and Clinical Symptoms in Patients with Severe and Moderate Asthma Journal of Mazandaran University of Medical Sciences asthma seroflo seretide spirometry children |
| title | Comparison of Seroflu and Seretide Inhalers on Spirometry Criteria and Clinical Symptoms in Patients with Severe and Moderate Asthma |
| title_full | Comparison of Seroflu and Seretide Inhalers on Spirometry Criteria and Clinical Symptoms in Patients with Severe and Moderate Asthma |
| title_fullStr | Comparison of Seroflu and Seretide Inhalers on Spirometry Criteria and Clinical Symptoms in Patients with Severe and Moderate Asthma |
| title_full_unstemmed | Comparison of Seroflu and Seretide Inhalers on Spirometry Criteria and Clinical Symptoms in Patients with Severe and Moderate Asthma |
| title_short | Comparison of Seroflu and Seretide Inhalers on Spirometry Criteria and Clinical Symptoms in Patients with Severe and Moderate Asthma |
| title_sort | comparison of seroflu and seretide inhalers on spirometry criteria and clinical symptoms in patients with severe and moderate asthma |
| topic | asthma seroflo seretide spirometry children |
| url | http://jmums.mazums.ac.ir/article-1-18560-en.pdf |
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