Lipophilic Statins Eliminate Senescent Endothelial Cells by inducing Anoikis-Related Cell Death

Lipophilic Statins Eliminate Senescent Endothelial Cells by inducing Anoikis-Related Cell Death

Pre-clinical studies from the recent past have indicated that senescent cells can negatively affect health and contribute to premature aging. Targeted eradication of these cells has been shown to improve the health of aged experimental animals, leading to a clinical interest in finding compounds tha...

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Bibliographic Details
Main Authors: Barbora Belakova, Nicholas K. Wedige, Ezzat M. Awad, Simon Hess, André Oszwald, Marlene Fellner, Shafaat Y. Khan, Ulrike Resch, Markus Lipovac, Karel Šmejkal, Pavel Uhrin, Johannes M. Breuss
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cells
Subjects:
endothelial cells
senescence
senolytics
statins
anoikis
apoptosis
Online Access:https://www.mdpi.com/2073-4409/12/24/2836

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