Prognostic significance of smac/DIABLO in endometrioid endometrial cancer.
Apoptosis may occur via a death receptor-dependent or independent (mitochondrial) pathway. The mitochondrial pathway is regulated by small molecules, such as smac/Diablo, which activates caspase cascades. This study examined smac/DIABLO expression in 76 patients with endometrioid endometrial cancers...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Via Medica
2011-04-01
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| Series: | Folia Histochemica et Cytobiologica |
| Online Access: | http://czasopisma.viamedica.pl/fhc/article/view/4181 |
| _version_ | 1831838931207847936 |
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| author | Magdalena Garbowicz Piotr S Bernaczyk Slawomir J Terlikowski Bozena Dobrzycka Jacek Niklinski Lech Chyczewski Marek Kulikowski |
| author_facet | Magdalena Garbowicz Piotr S Bernaczyk Slawomir J Terlikowski Bozena Dobrzycka Jacek Niklinski Lech Chyczewski Marek Kulikowski |
| author_sort | Magdalena Garbowicz |
| collection | DOAJ |
| description | Apoptosis may occur via a death receptor-dependent or independent (mitochondrial) pathway. The mitochondrial pathway is regulated by small molecules, such as smac/Diablo, which activates caspase cascades. This study examined smac/DIABLO expression in 76 patients with endometrioid endometrial cancers. Presence of smac/DIABLO was quantified by Western blot analysis using nonfixed fresh frozen tissues. Its appearance was found in 55 (72%) of examined tumors. Smac/DIABLO expression significantly correlated with tumor grade (p<0.001). Patients with positive smac/DIABLO tumors had a longer disease-specific survival when compared with those with negative tumors in the 10-year follow-up (p=0.043). The study demonstrated that negative smac/DIABLO expression was a poor prognostic sign. |
| first_indexed | 2024-12-23T05:42:11Z |
| format | Article |
| id | doaj.art-5421d7156f224e14be8d963324676972 |
| institution | Directory Open Access Journal |
| issn | 0239-8508 1897-5631 |
| language | English |
| last_indexed | 2024-12-23T05:42:11Z |
| publishDate | 2011-04-01 |
| publisher | Via Medica |
| record_format | Article |
| series | Folia Histochemica et Cytobiologica |
| spelling | doaj.art-5421d7156f224e14be8d9633246769722022-12-21T17:58:08ZengVia MedicaFolia Histochemica et Cytobiologica0239-85081897-56312011-04-0148467868110.5603/4181Prognostic significance of smac/DIABLO in endometrioid endometrial cancer.Magdalena GarbowiczPiotr S BernaczykSlawomir J TerlikowskiBozena DobrzyckaJacek NiklinskiLech ChyczewskiMarek KulikowskiApoptosis may occur via a death receptor-dependent or independent (mitochondrial) pathway. The mitochondrial pathway is regulated by small molecules, such as smac/Diablo, which activates caspase cascades. This study examined smac/DIABLO expression in 76 patients with endometrioid endometrial cancers. Presence of smac/DIABLO was quantified by Western blot analysis using nonfixed fresh frozen tissues. Its appearance was found in 55 (72%) of examined tumors. Smac/DIABLO expression significantly correlated with tumor grade (p<0.001). Patients with positive smac/DIABLO tumors had a longer disease-specific survival when compared with those with negative tumors in the 10-year follow-up (p=0.043). The study demonstrated that negative smac/DIABLO expression was a poor prognostic sign.http://czasopisma.viamedica.pl/fhc/article/view/4181 |
| spellingShingle | Magdalena Garbowicz Piotr S Bernaczyk Slawomir J Terlikowski Bozena Dobrzycka Jacek Niklinski Lech Chyczewski Marek Kulikowski Prognostic significance of smac/DIABLO in endometrioid endometrial cancer. Folia Histochemica et Cytobiologica |
| title | Prognostic significance of smac/DIABLO in endometrioid endometrial cancer. |
| title_full | Prognostic significance of smac/DIABLO in endometrioid endometrial cancer. |
| title_fullStr | Prognostic significance of smac/DIABLO in endometrioid endometrial cancer. |
| title_full_unstemmed | Prognostic significance of smac/DIABLO in endometrioid endometrial cancer. |
| title_short | Prognostic significance of smac/DIABLO in endometrioid endometrial cancer. |
| title_sort | prognostic significance of smac diablo in endometrioid endometrial cancer |
| url | http://czasopisma.viamedica.pl/fhc/article/view/4181 |
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