The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad
When the first vaccines against SARS-CoV-2 emerged, pregnant women were excluded from clinical trials, so vaccine recommendations were initially adjourned, with late initiation for this populational category. The present study aims to quantify the serum and breastmilk values of SARS-CoV-2 spike prot...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/6/848 |
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| author | Daniela-Eugenia Popescu Cosmin Cîtu Ana Maria Cristina Jura Nicoleta Lungu Dan Navolan Marius Craina Alin Semenescu Florin Gorun Mihai-Andrei Jura Valerica Belengeanu Marioara Boia |
| author_facet | Daniela-Eugenia Popescu Cosmin Cîtu Ana Maria Cristina Jura Nicoleta Lungu Dan Navolan Marius Craina Alin Semenescu Florin Gorun Mihai-Andrei Jura Valerica Belengeanu Marioara Boia |
| author_sort | Daniela-Eugenia Popescu |
| collection | DOAJ |
| description | When the first vaccines against SARS-CoV-2 emerged, pregnant women were excluded from clinical trials, so vaccine recommendations were initially adjourned, with late initiation for this populational category. The present study aims to quantify the serum and breastmilk values of SARS-CoV-2 spike protein antibodies in both the mother and her newborn after complete vaccination during pregnancy. Ninety-one vaccinated patients were included, some of whom presented COVID-19 infection during pregnancy. In the delivery room, venous blood was collected from the mother and umbilical cord blood from her offspring. All samples were processed using the ECLIA (electrochemiluminescence) method. Breastmilk was collected and tested during the third postnatal day. The highest maternal serum values were 19,523 U/mL (detection limit > 0.8 U/mL) and in breastmilk, 206.7 U/mL. Every single newborn had antibody values higher than 0, with a mean serum value (M = 5288.37, SD = 5661.49) significantly higher than 0, <i>t</i>(90) = 8.91, <i>p</i> < 0.001. Consequently, this study intents to emphasize the importance of vaccination against SARS-CoV-2 during pregnancy. This double kind of neonatal protection, attained by placental and breastmilk transfer, can be accomplished by encouraging vaccination, breastfeeding, bonding, and providing maternal empowerment to participate in her infant’s care. |
| first_indexed | 2024-03-09T22:17:11Z |
| format | Article |
| id | doaj.art-5421f860f321428c8f26fd81cf020e48 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T22:17:11Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-5421f860f321428c8f26fd81cf020e482023-11-23T19:20:13ZengMDPI AGVaccines2076-393X2022-05-0110684810.3390/vaccines10060848The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn DyadDaniela-Eugenia Popescu0Cosmin Cîtu1Ana Maria Cristina Jura2Nicoleta Lungu3Dan Navolan4Marius Craina5Alin Semenescu6Florin Gorun7Mihai-Andrei Jura8Valerica Belengeanu9Marioara Boia10Department of Obstetrics-Gynecology and Neonatology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of Obstetrics-Gynecology and Neonatology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of Neonatology, “Louis Țurcanu” Children Emergency Clinical Hospital Timișoara, 300011 Timisoara, RomaniaDepartment of Obstetrics-Gynecology and Neonatology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of Obstetrics-Gynecology and Neonatology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of Obstetrics-Gynecology and Neonatology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaInstitute for Advanced Environmental Research (ICAM), West University of Timisoara, 300223 Timisoara, RomaniaDepartment of Obstetrics-Gynecology and Neonatology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of Epidemiology, “Pius Brinzeu” Emergency County Hospital Timisoara, 300736 Timisoara, RomaniaDepartment of Genetics, Institute of Life Science, Faculty of Medicine, “Vasile Goldiş” Western University of Arad, 310025 Arad, RomaniaDepartment of Obstetrics-Gynecology and Neonatology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaWhen the first vaccines against SARS-CoV-2 emerged, pregnant women were excluded from clinical trials, so vaccine recommendations were initially adjourned, with late initiation for this populational category. The present study aims to quantify the serum and breastmilk values of SARS-CoV-2 spike protein antibodies in both the mother and her newborn after complete vaccination during pregnancy. Ninety-one vaccinated patients were included, some of whom presented COVID-19 infection during pregnancy. In the delivery room, venous blood was collected from the mother and umbilical cord blood from her offspring. All samples were processed using the ECLIA (electrochemiluminescence) method. Breastmilk was collected and tested during the third postnatal day. The highest maternal serum values were 19,523 U/mL (detection limit > 0.8 U/mL) and in breastmilk, 206.7 U/mL. Every single newborn had antibody values higher than 0, with a mean serum value (M = 5288.37, SD = 5661.49) significantly higher than 0, <i>t</i>(90) = 8.91, <i>p</i> < 0.001. Consequently, this study intents to emphasize the importance of vaccination against SARS-CoV-2 during pregnancy. This double kind of neonatal protection, attained by placental and breastmilk transfer, can be accomplished by encouraging vaccination, breastfeeding, bonding, and providing maternal empowerment to participate in her infant’s care.https://www.mdpi.com/2076-393X/10/6/848vaccinationSARS-CoV-2COVID-19pregnancynewbornspike protein |
| spellingShingle | Daniela-Eugenia Popescu Cosmin Cîtu Ana Maria Cristina Jura Nicoleta Lungu Dan Navolan Marius Craina Alin Semenescu Florin Gorun Mihai-Andrei Jura Valerica Belengeanu Marioara Boia The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad Vaccines vaccination SARS-CoV-2 COVID-19 pregnancy newborn spike protein |
| title | The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad |
| title_full | The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad |
| title_fullStr | The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad |
| title_full_unstemmed | The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad |
| title_short | The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad |
| title_sort | benefits of vaccination against sars cov 2 during pregnancy in favor of the mother newborn dyad |
| topic | vaccination SARS-CoV-2 COVID-19 pregnancy newborn spike protein |
| url | https://www.mdpi.com/2076-393X/10/6/848 |
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