Gold-Derived Molecules as New Antimicrobial Agents
Antimicrobial resistance is considered one of the three most important health problems by the World Health Organization. The emergence and spread of an increasing number of antimicrobial-resistant microorganisms make this a worldwide problem. Antibiotic-resistant bacteria are estimated to be the cau...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.846959/full |
| _version_ | 1819174488262049792 |
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| author | Carlos Ratia Raquel G. Soengas Sara M. Soto |
| author_facet | Carlos Ratia Raquel G. Soengas Sara M. Soto |
| author_sort | Carlos Ratia |
| collection | DOAJ |
| description | Antimicrobial resistance is considered one of the three most important health problems by the World Health Organization. The emergence and spread of an increasing number of antimicrobial-resistant microorganisms make this a worldwide problem. Antibiotic-resistant bacteria are estimated to be the cause of 33,000 deaths in Europe and 700,000 worldwide each year. It is estimated that in 2050 bacterial infections will cause 10 million deaths across the globe. This problem is concomitant with a decrease in the investment and, therefore, the discovery and marketing of new antibiotics. Recently, there have been tremendous efforts to find new effective antimicrobial agents. Gold complexes, with their broad-spectrum antimicrobial activities and unique modes of action, are particularly relevant among several families of derivatives that have been investigated. This mini review revises the role of gold-derived molecules as antibacterial agents. |
| first_indexed | 2024-12-22T20:39:46Z |
| format | Article |
| id | doaj.art-54229068ea5142daa9f477c4ca8e5cce |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-22T20:39:46Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-54229068ea5142daa9f477c4ca8e5cce2022-12-21T18:13:21ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-03-011310.3389/fmicb.2022.846959846959Gold-Derived Molecules as New Antimicrobial AgentsCarlos Ratia0Raquel G. Soengas1Sara M. Soto2ISGlobal, Hospital Clínic—Universitat de Barcelona, Barcelona, SpainDepartamento de Química Orgánica e Inorgánica, Universidad de Oviedo, Oviedo, SpainISGlobal, Hospital Clínic—Universitat de Barcelona, Barcelona, SpainAntimicrobial resistance is considered one of the three most important health problems by the World Health Organization. The emergence and spread of an increasing number of antimicrobial-resistant microorganisms make this a worldwide problem. Antibiotic-resistant bacteria are estimated to be the cause of 33,000 deaths in Europe and 700,000 worldwide each year. It is estimated that in 2050 bacterial infections will cause 10 million deaths across the globe. This problem is concomitant with a decrease in the investment and, therefore, the discovery and marketing of new antibiotics. Recently, there have been tremendous efforts to find new effective antimicrobial agents. Gold complexes, with their broad-spectrum antimicrobial activities and unique modes of action, are particularly relevant among several families of derivatives that have been investigated. This mini review revises the role of gold-derived molecules as antibacterial agents.https://www.frontiersin.org/articles/10.3389/fmicb.2022.846959/fullgold(I) complexesgold(III) complexesantibacterialmechanism of actiontoxicity |
| spellingShingle | Carlos Ratia Raquel G. Soengas Sara M. Soto Gold-Derived Molecules as New Antimicrobial Agents Frontiers in Microbiology gold(I) complexes gold(III) complexes antibacterial mechanism of action toxicity |
| title | Gold-Derived Molecules as New Antimicrobial Agents |
| title_full | Gold-Derived Molecules as New Antimicrobial Agents |
| title_fullStr | Gold-Derived Molecules as New Antimicrobial Agents |
| title_full_unstemmed | Gold-Derived Molecules as New Antimicrobial Agents |
| title_short | Gold-Derived Molecules as New Antimicrobial Agents |
| title_sort | gold derived molecules as new antimicrobial agents |
| topic | gold(I) complexes gold(III) complexes antibacterial mechanism of action toxicity |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.846959/full |
| work_keys_str_mv | AT carlosratia goldderivedmoleculesasnewantimicrobialagents AT raquelgsoengas goldderivedmoleculesasnewantimicrobialagents AT saramsoto goldderivedmoleculesasnewantimicrobialagents |