Downregulation of metallothionein-2 contributes to oxaliplatin-induced neuropathic pain

Downregulation of metallothionein-2 contributes to oxaliplatin-induced neuropathic pain

Abstract Background We previously reported a correlation between small doses of oxaliplatin penetrating onto the spinal cord and acute pain after chemotherapy. Here, we propose that MT2 within the spinal dorsal horns participates in the development of oxaliplatin-induced neuropathic pain and may be...

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Bibliographic Details
Main Authors: Xuelin Huang, Jie Deng, Ting Xu, Wenjun Xin, Yuehong Zhang, Xiangcai Ruan
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Journal of Neuroinflammation
Subjects:
Chemotherapy-induced peripheral neuropathy
Metallothionein-2
Oxaliplatin
Mechanical allodynia
NF-κB
Online Access:https://doi.org/10.1186/s12974-021-02139-6

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