Spinal cord RNA-seq data after a baclofen treatment in mice with a spinal cord injury
Spinal cord injury (SCI) leads to severe functional deficits. Currently, there are no available pharmacological treatments to promote neurological recovery in SCI patients. Recent work from our group has shown that a baclofen treatment can promote functional recovery after a compression SCI in mice...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Data in Brief |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340922010125 |
| _version_ | 1828048319942754304 |
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| author | Nidia de Sousa Diego Robledo Laura González-Llera Andreia G. Pinho Diogo J. Santos Susana Monteiro Jonas Campos Jorge R. Cibrão Nuno A. Silva Laura Sánchez António J. Salgado Antón Barreiro-Iglesias |
| author_facet | Nidia de Sousa Diego Robledo Laura González-Llera Andreia G. Pinho Diogo J. Santos Susana Monteiro Jonas Campos Jorge R. Cibrão Nuno A. Silva Laura Sánchez António J. Salgado Antón Barreiro-Iglesias |
| author_sort | Nidia de Sousa |
| collection | DOAJ |
| description | Spinal cord injury (SCI) leads to severe functional deficits. Currently, there are no available pharmacological treatments to promote neurological recovery in SCI patients. Recent work from our group has shown that a baclofen treatment can promote functional recovery after a compression SCI in mice [1]. Here, we provide transcriptomic (RNA-seq) data from adult mouse spinal cords collected 7 days after a compression SCI and baclofen (vs vehicle) administration. The Illumina NovaSeq 6000 platform was used to generate the raw transcriptomic data. In addition, we also present bioinformatic analyses including differential gene expression analysis, enrichment analyses for various functional annotations (gene ontology, KEGG and BioCarta pathways or InterPro domains) and transcription factor targets. The raw RNA-seq data has been uploaded to the NCBI Sequence Read Archive (SRA) database (Bioproject ID PRJNA886048). The data generated from the bioinformatic analyses is contained within the article. |
| first_indexed | 2024-04-10T18:54:34Z |
| format | Article |
| id | doaj.art-542416f6e1014042b9a0a89f44ad5fa1 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-04-10T18:54:34Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-542416f6e1014042b9a0a89f44ad5fa12023-02-01T04:26:11ZengElsevierData in Brief2352-34092023-02-0146108809Spinal cord RNA-seq data after a baclofen treatment in mice with a spinal cord injuryNidia de Sousa0Diego Robledo1Laura González-Llera2Andreia G. Pinho3Diogo J. Santos4Susana Monteiro5Jonas Campos6Jorge R. Cibrão7Nuno A. Silva8Laura Sánchez9António J. Salgado10Antón Barreiro-Iglesias11ICVS/3B's Associate Lab, PT Government Associated Lab, Braga/Guimarães 4806-909, Portugal; School of Medicine, Life and Health Sciences Research Institute (ICVS), University of Minho, Braga 4710-057, PortugalThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG, UKDepartment of Functional Biology, Faculty of Biology, CIBUS, Universidade de Santiago de Compostela, Santiago de Compostela 15782, SpainICVS/3B's Associate Lab, PT Government Associated Lab, Braga/Guimarães 4806-909, Portugal; School of Medicine, Life and Health Sciences Research Institute (ICVS), University of Minho, Braga 4710-057, PortugalICVS/3B's Associate Lab, PT Government Associated Lab, Braga/Guimarães 4806-909, Portugal; School of Medicine, Life and Health Sciences Research Institute (ICVS), University of Minho, Braga 4710-057, PortugalICVS/3B's Associate Lab, PT Government Associated Lab, Braga/Guimarães 4806-909, Portugal; School of Medicine, Life and Health Sciences Research Institute (ICVS), University of Minho, Braga 4710-057, PortugalICVS/3B's Associate Lab, PT Government Associated Lab, Braga/Guimarães 4806-909, Portugal; School of Medicine, Life and Health Sciences Research Institute (ICVS), University of Minho, Braga 4710-057, PortugalICVS/3B's Associate Lab, PT Government Associated Lab, Braga/Guimarães 4806-909, Portugal; School of Medicine, Life and Health Sciences Research Institute (ICVS), University of Minho, Braga 4710-057, PortugalICVS/3B's Associate Lab, PT Government Associated Lab, Braga/Guimarães 4806-909, Portugal; School of Medicine, Life and Health Sciences Research Institute (ICVS), University of Minho, Braga 4710-057, PortugalDepartment of Zoology, Genetics and Physical Anthropology, Faculty of Veterinary Science, Universidade de Santiago de Compostela, Lugo 27002, Spain; Preclinical Animal Models Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela 15706, SpainICVS/3B's Associate Lab, PT Government Associated Lab, Braga/Guimarães 4806-909, Portugal; School of Medicine, Life and Health Sciences Research Institute (ICVS), University of Minho, Braga 4710-057, PortugalDepartment of Functional Biology, Faculty of Biology, CIBUS, Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain; Corresponding author.Spinal cord injury (SCI) leads to severe functional deficits. Currently, there are no available pharmacological treatments to promote neurological recovery in SCI patients. Recent work from our group has shown that a baclofen treatment can promote functional recovery after a compression SCI in mice [1]. Here, we provide transcriptomic (RNA-seq) data from adult mouse spinal cords collected 7 days after a compression SCI and baclofen (vs vehicle) administration. The Illumina NovaSeq 6000 platform was used to generate the raw transcriptomic data. In addition, we also present bioinformatic analyses including differential gene expression analysis, enrichment analyses for various functional annotations (gene ontology, KEGG and BioCarta pathways or InterPro domains) and transcription factor targets. The raw RNA-seq data has been uploaded to the NCBI Sequence Read Archive (SRA) database (Bioproject ID PRJNA886048). The data generated from the bioinformatic analyses is contained within the article.http://www.sciencedirect.com/science/article/pii/S2352340922010125BaclofenSpinal cord injuryRNA-seqTraumatic nervous system injuryNeuroprotectionRegeneration |
| spellingShingle | Nidia de Sousa Diego Robledo Laura González-Llera Andreia G. Pinho Diogo J. Santos Susana Monteiro Jonas Campos Jorge R. Cibrão Nuno A. Silva Laura Sánchez António J. Salgado Antón Barreiro-Iglesias Spinal cord RNA-seq data after a baclofen treatment in mice with a spinal cord injury Data in Brief Baclofen Spinal cord injury RNA-seq Traumatic nervous system injury Neuroprotection Regeneration |
| title | Spinal cord RNA-seq data after a baclofen treatment in mice with a spinal cord injury |
| title_full | Spinal cord RNA-seq data after a baclofen treatment in mice with a spinal cord injury |
| title_fullStr | Spinal cord RNA-seq data after a baclofen treatment in mice with a spinal cord injury |
| title_full_unstemmed | Spinal cord RNA-seq data after a baclofen treatment in mice with a spinal cord injury |
| title_short | Spinal cord RNA-seq data after a baclofen treatment in mice with a spinal cord injury |
| title_sort | spinal cord rna seq data after a baclofen treatment in mice with a spinal cord injury |
| topic | Baclofen Spinal cord injury RNA-seq Traumatic nervous system injury Neuroprotection Regeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2352340922010125 |
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