Applicability of the Sarculator and MSKCC nomograms to retroperitoneal sarcoma prognostication in an Asian tertiary center
Aim: To study the applicability of 2 common nomograms in retroperitoneal sarcoma patients treated in an Asian tertiary hospital, and to study relapse patterns. Methods: Patients from 1st January 2000 to 31st December 2017 were retrospectively analysed. R2 resection from an external institution were...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-11-01
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| Series: | Asian Journal of Surgery |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958420300105 |
| _version_ | 1818116432931586048 |
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| author | Ru Xin Wong Yen Sin Koh Faith Ong M. Farid Timothy Kwang Yong Tay Melissa Teo |
| author_facet | Ru Xin Wong Yen Sin Koh Faith Ong M. Farid Timothy Kwang Yong Tay Melissa Teo |
| author_sort | Ru Xin Wong |
| collection | DOAJ |
| description | Aim: To study the applicability of 2 common nomograms in retroperitoneal sarcoma patients treated in an Asian tertiary hospital, and to study relapse patterns. Methods: Patients from 1st January 2000 to 31st December 2017 were retrospectively analysed. R2 resection from an external institution were ineligible. Harrel's C concordance index and calibration plots were used to assess nomograms' accuracy. Results: 109 patients were eligible, with a median age of 56, median tumour size of 16 cm and median follow up of 44.1 months. Most common subtypes were DDLPS (46.8%), LMS (19.3%) and WDLPS (13.8%). Overall, 81.1% had passed away from sarcoma. Recurrence patterns differed with subtypes; 6.7% of WDLPS and 66.7% of LMS had distant relapses. WDLPS patients had a median sarcoma specific survival of 139 months (122-NA), while the rest had a median SSS of 72.3 months (59.7-NA). The 5-years and 7-year OS were 63.0% (95% CI: 53.6%–74.0%) and 51.6% (41.1%–64.8%) respectively. The 5-years and 7-year DFS were 22.4% (15.5%–32.3%) and 17.5% (11%–27.8%) respectively. The 4-years, 8-years and 12-year SSS were 71.3% (62.7%–81.0%), 51.8% (40.8%–65.8%) and 32.2% (19.7%–52.6%) respectively. The concordance indices for 7-year DFS and OS (Sarculator) were 0.63 and 0.73. The concordance indices for 4-, 8- and 12-year SSS (MSKCC) were 0.64, 0.72 and 0.72. Conclusion: Both nomograms were effective in our cohort. Both nomograms can be further improved by specifying the type of relapse and including a longer-term endpoint for the Sarculator. |
| first_indexed | 2024-12-11T04:22:26Z |
| format | Article |
| id | doaj.art-54243c76c07949d797ab287f2d875238 |
| institution | Directory Open Access Journal |
| issn | 1015-9584 |
| language | English |
| last_indexed | 2024-12-11T04:22:26Z |
| publishDate | 2020-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj.art-54243c76c07949d797ab287f2d8752382022-12-22T01:21:05ZengElsevierAsian Journal of Surgery1015-95842020-11-01431110781085Applicability of the Sarculator and MSKCC nomograms to retroperitoneal sarcoma prognostication in an Asian tertiary centerRu Xin Wong0Yen Sin Koh1Faith Ong2M. Farid3Timothy Kwang Yong Tay4Melissa Teo5National Cancer Centre Singapore, Department of Radiation Oncology, Singapore; Corresponding author. Department of radiation oncology, 11 Hospital Drive, 169610, Singapore.National Cancer Centre Singapore, Department of Radiation Oncology, SingaporeYong Loo Lin School of Medicine, National University of Singapore, SingaporeNational Cancer Centre Singapore, Department of Medical Oncology, SingaporeSingapore General Hospital, Department of Anatomical Pathology, SingaporeNational Cancer Centre, Department of Surgical Oncology, SingaporeAim: To study the applicability of 2 common nomograms in retroperitoneal sarcoma patients treated in an Asian tertiary hospital, and to study relapse patterns. Methods: Patients from 1st January 2000 to 31st December 2017 were retrospectively analysed. R2 resection from an external institution were ineligible. Harrel's C concordance index and calibration plots were used to assess nomograms' accuracy. Results: 109 patients were eligible, with a median age of 56, median tumour size of 16 cm and median follow up of 44.1 months. Most common subtypes were DDLPS (46.8%), LMS (19.3%) and WDLPS (13.8%). Overall, 81.1% had passed away from sarcoma. Recurrence patterns differed with subtypes; 6.7% of WDLPS and 66.7% of LMS had distant relapses. WDLPS patients had a median sarcoma specific survival of 139 months (122-NA), while the rest had a median SSS of 72.3 months (59.7-NA). The 5-years and 7-year OS were 63.0% (95% CI: 53.6%–74.0%) and 51.6% (41.1%–64.8%) respectively. The 5-years and 7-year DFS were 22.4% (15.5%–32.3%) and 17.5% (11%–27.8%) respectively. The 4-years, 8-years and 12-year SSS were 71.3% (62.7%–81.0%), 51.8% (40.8%–65.8%) and 32.2% (19.7%–52.6%) respectively. The concordance indices for 7-year DFS and OS (Sarculator) were 0.63 and 0.73. The concordance indices for 4-, 8- and 12-year SSS (MSKCC) were 0.64, 0.72 and 0.72. Conclusion: Both nomograms were effective in our cohort. Both nomograms can be further improved by specifying the type of relapse and including a longer-term endpoint for the Sarculator.http://www.sciencedirect.com/science/article/pii/S1015958420300105NomogramsNeoplasm gradingPeritoneumSarcoma |
| spellingShingle | Ru Xin Wong Yen Sin Koh Faith Ong M. Farid Timothy Kwang Yong Tay Melissa Teo Applicability of the Sarculator and MSKCC nomograms to retroperitoneal sarcoma prognostication in an Asian tertiary center Asian Journal of Surgery Nomograms Neoplasm grading Peritoneum Sarcoma |
| title | Applicability of the Sarculator and MSKCC nomograms to retroperitoneal sarcoma prognostication in an Asian tertiary center |
| title_full | Applicability of the Sarculator and MSKCC nomograms to retroperitoneal sarcoma prognostication in an Asian tertiary center |
| title_fullStr | Applicability of the Sarculator and MSKCC nomograms to retroperitoneal sarcoma prognostication in an Asian tertiary center |
| title_full_unstemmed | Applicability of the Sarculator and MSKCC nomograms to retroperitoneal sarcoma prognostication in an Asian tertiary center |
| title_short | Applicability of the Sarculator and MSKCC nomograms to retroperitoneal sarcoma prognostication in an Asian tertiary center |
| title_sort | applicability of the sarculator and mskcc nomograms to retroperitoneal sarcoma prognostication in an asian tertiary center |
| topic | Nomograms Neoplasm grading Peritoneum Sarcoma |
| url | http://www.sciencedirect.com/science/article/pii/S1015958420300105 |
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