Disease Burden of Clostridium difficile Infections in Adults, Hong Kong, China, 2006–2014
Cross-sectional studies suggest an increasing trend in incidence and relatively low recurrence rates of Clostridium difficile infections in Asia than in Europe and North America. The temporal trend of C. difficile infection in Asia is not completely understood. We conducted a territory-wide populati...
Main Authors: | , , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
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Centers for Disease Control and Prevention
2017-10-01
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Series: | Emerging Infectious Diseases |
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Online Access: | https://wwwnc.cdc.gov/eid/article/23/10/17-0797_article |
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author | Jeffery Ho Rudin Z.W. Dai Thomas N.Y. Kwong Xiansong Wang Lin Zhang Margaret Ip Raphael Chan Peter M.K. Hawkey Kelvin L.Y. Lam Martin C.S. Wong Gary Tse Matthew T.V. Chan Francis K.L. Chan Jun Yu Siew C. Ng Nelson Lee Justin C.Y. Wu Joseph J.Y. Sung William K.K. Wu Sunny H. Wong |
author_facet | Jeffery Ho Rudin Z.W. Dai Thomas N.Y. Kwong Xiansong Wang Lin Zhang Margaret Ip Raphael Chan Peter M.K. Hawkey Kelvin L.Y. Lam Martin C.S. Wong Gary Tse Matthew T.V. Chan Francis K.L. Chan Jun Yu Siew C. Ng Nelson Lee Justin C.Y. Wu Joseph J.Y. Sung William K.K. Wu Sunny H. Wong |
author_sort | Jeffery Ho |
collection | DOAJ |
description | Cross-sectional studies suggest an increasing trend in incidence and relatively low recurrence rates of Clostridium difficile infections in Asia than in Europe and North America. The temporal trend of C. difficile infection in Asia is not completely understood. We conducted a territory-wide population-based observational study to investigate the burden and clinical outcomes in Hong Kong, China, over a 9-year period. A total of 15,753 cases were identified, including 14,402 (91.4%) healthcare-associated cases and 817 (5.1%) community-associated cases. After adjustment for diagnostic test, we found that incidence increased from 15.41 cases/100,000 persons in 2006 to 36.31 cases/100,000 persons in 2014, an annual increase of 26%. This increase was associated with elderly patients, for whom incidence increased 3-fold over the period. Recurrence at 60 days increased from 5.7% in 2006 to 9.1% in 2014 (p<0.001). Our data suggest the need for further surveillance, especially in Asia, which contains ≈60% of the world’s population. |
first_indexed | 2024-04-13T13:20:35Z |
format | Article |
id | doaj.art-5425301ae3b447d298994649bf4e9573 |
institution | Directory Open Access Journal |
issn | 1080-6040 1080-6059 |
language | English |
last_indexed | 2024-04-13T13:20:35Z |
publishDate | 2017-10-01 |
publisher | Centers for Disease Control and Prevention |
record_format | Article |
series | Emerging Infectious Diseases |
spelling | doaj.art-5425301ae3b447d298994649bf4e95732022-12-22T02:45:20ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592017-10-0123101671167910.3201/eid2310.170797Disease Burden of Clostridium difficile Infections in Adults, Hong Kong, China, 2006–2014Jeffery HoRudin Z.W. DaiThomas N.Y. KwongXiansong WangLin ZhangMargaret IpRaphael ChanPeter M.K. HawkeyKelvin L.Y. LamMartin C.S. WongGary TseMatthew T.V. ChanFrancis K.L. ChanJun YuSiew C. NgNelson LeeJustin C.Y. WuJoseph J.Y. SungWilliam K.K. WuSunny H. WongCross-sectional studies suggest an increasing trend in incidence and relatively low recurrence rates of Clostridium difficile infections in Asia than in Europe and North America. The temporal trend of C. difficile infection in Asia is not completely understood. We conducted a territory-wide population-based observational study to investigate the burden and clinical outcomes in Hong Kong, China, over a 9-year period. A total of 15,753 cases were identified, including 14,402 (91.4%) healthcare-associated cases and 817 (5.1%) community-associated cases. After adjustment for diagnostic test, we found that incidence increased from 15.41 cases/100,000 persons in 2006 to 36.31 cases/100,000 persons in 2014, an annual increase of 26%. This increase was associated with elderly patients, for whom incidence increased 3-fold over the period. Recurrence at 60 days increased from 5.7% in 2006 to 9.1% in 2014 (p<0.001). Our data suggest the need for further surveillance, especially in Asia, which contains ≈60% of the world’s population.https://wwwnc.cdc.gov/eid/article/23/10/17-0797_articleClostridium difficilebacteriainfectionspseudomembranous colitissurveillanceepidemiology |
spellingShingle | Jeffery Ho Rudin Z.W. Dai Thomas N.Y. Kwong Xiansong Wang Lin Zhang Margaret Ip Raphael Chan Peter M.K. Hawkey Kelvin L.Y. Lam Martin C.S. Wong Gary Tse Matthew T.V. Chan Francis K.L. Chan Jun Yu Siew C. Ng Nelson Lee Justin C.Y. Wu Joseph J.Y. Sung William K.K. Wu Sunny H. Wong Disease Burden of Clostridium difficile Infections in Adults, Hong Kong, China, 2006–2014 Emerging Infectious Diseases Clostridium difficile bacteria infections pseudomembranous colitis surveillance epidemiology |
title | Disease Burden of Clostridium difficile Infections in Adults, Hong Kong, China, 2006–2014 |
title_full | Disease Burden of Clostridium difficile Infections in Adults, Hong Kong, China, 2006–2014 |
title_fullStr | Disease Burden of Clostridium difficile Infections in Adults, Hong Kong, China, 2006–2014 |
title_full_unstemmed | Disease Burden of Clostridium difficile Infections in Adults, Hong Kong, China, 2006–2014 |
title_short | Disease Burden of Clostridium difficile Infections in Adults, Hong Kong, China, 2006–2014 |
title_sort | disease burden of clostridium difficile infections in adults hong kong china 2006 2014 |
topic | Clostridium difficile bacteria infections pseudomembranous colitis surveillance epidemiology |
url | https://wwwnc.cdc.gov/eid/article/23/10/17-0797_article |
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