Triglyceride Glucose Index and Prognosis of Patients With Ischemic Stroke
Background: The triglyceride glucose index (TyG index) has been proposed as a simple and credible surrogate marker of insulin resistance. However, it is unclear whether TyG index correlates with adverse clinical outcomes in patients with ischemic stroke. Accordingly, this study aimed to explore the...
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.00456/full |
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| author | Yimo Zhou Yimo Zhou Yimo Zhou Yimo Zhou Yuesong Pan Yuesong Pan Yuesong Pan Yuesong Pan Hongyi Yan Hongyi Yan Hongyi Yan Hongyi Yan Yilong Wang Yilong Wang Yilong Wang Yilong Wang Zixiao Li Zixiao Li Zixiao Li Zixiao Li Xingquan Zhao Xingquan Zhao Xingquan Zhao Xingquan Zhao Hao Li Hao Li Hao Li Hao Li Xia Meng Xia Meng Xia Meng Xia Meng Chunxue Wang Chunxue Wang Chunxue Wang Chunxue Wang Liping Liu Liping Liu Liping Liu Liping Liu Yongjun Wang Yongjun Wang Yongjun Wang Yongjun Wang |
| author_facet | Yimo Zhou Yimo Zhou Yimo Zhou Yimo Zhou Yuesong Pan Yuesong Pan Yuesong Pan Yuesong Pan Hongyi Yan Hongyi Yan Hongyi Yan Hongyi Yan Yilong Wang Yilong Wang Yilong Wang Yilong Wang Zixiao Li Zixiao Li Zixiao Li Zixiao Li Xingquan Zhao Xingquan Zhao Xingquan Zhao Xingquan Zhao Hao Li Hao Li Hao Li Hao Li Xia Meng Xia Meng Xia Meng Xia Meng Chunxue Wang Chunxue Wang Chunxue Wang Chunxue Wang Liping Liu Liping Liu Liping Liu Liping Liu Yongjun Wang Yongjun Wang Yongjun Wang Yongjun Wang |
| author_sort | Yimo Zhou |
| collection | DOAJ |
| description | Background: The triglyceride glucose index (TyG index) has been proposed as a simple and credible surrogate marker of insulin resistance. However, it is unclear whether TyG index correlates with adverse clinical outcomes in patients with ischemic stroke. Accordingly, this study aimed to explore the relationship between baseline TyG index and clinical outcomes of ischemic stroke individuals.Methods: We included eligible subjects with ischemic stroke from the China National Stroke Registry II for the current analysis. TyG index was calculated and divided into quartiles to explore the relationship with the outcomes of ischemic stroke. Outcomes included stroke recurrence, all-cause mortality, poor functional outcome at 12 months, and neurologic worsening at discharge. Multivariable Cox regression and logistic regression models were performed to explore the correlation of baseline TyG index with the outcomes.Results: Among the 16,310 patients enrolled in the study, the average age was 64.83 ± 11.9 years, and 63.48% were men. The median TyG index was 8.73 (interquartile range, 8.33–9.21). After adjustment for multiple potential covariates, the fourth quartile of TyG index was associated with an increased risk of stroke recurrence (adjusted HR, 1.32; 95% CI, 1.11–1.57; P = 0.002), all-cause mortality (adjusted HR, 1.25; 95%CI, 1.06–1.47; P = 0.01) at 12-month follow-up, and neurological worsening (adjusted OR, 1.26; 95% CI, 1.02–1.55; P = 0.03) at discharge, but not poor functional outcome compared with the first quartile.Conclusion: TyG index representing insulin resistance was associated with an increased risk of stroke recurrence, all-cause mortality, and neurologic worsening in patients with ischemic stroke. |
| first_indexed | 2024-12-21T13:43:23Z |
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| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-21T13:43:23Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-5425881ab89349fbbba99593e5bbfc992022-12-21T19:01:57ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-06-011110.3389/fneur.2020.00456529408Triglyceride Glucose Index and Prognosis of Patients With Ischemic StrokeYimo Zhou0Yimo Zhou1Yimo Zhou2Yimo Zhou3Yuesong Pan4Yuesong Pan5Yuesong Pan6Yuesong Pan7Hongyi Yan8Hongyi Yan9Hongyi Yan10Hongyi Yan11Yilong Wang12Yilong Wang13Yilong Wang14Yilong Wang15Zixiao Li16Zixiao Li17Zixiao Li18Zixiao Li19Xingquan Zhao20Xingquan Zhao21Xingquan Zhao22Xingquan Zhao23Hao Li24Hao Li25Hao Li26Hao Li27Xia Meng28Xia Meng29Xia Meng30Xia Meng31Chunxue Wang32Chunxue Wang33Chunxue Wang34Chunxue Wang35Liping Liu36Liping Liu37Liping Liu38Liping Liu39Yongjun Wang40Yongjun Wang41Yongjun Wang42Yongjun Wang43Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaBackground: The triglyceride glucose index (TyG index) has been proposed as a simple and credible surrogate marker of insulin resistance. However, it is unclear whether TyG index correlates with adverse clinical outcomes in patients with ischemic stroke. Accordingly, this study aimed to explore the relationship between baseline TyG index and clinical outcomes of ischemic stroke individuals.Methods: We included eligible subjects with ischemic stroke from the China National Stroke Registry II for the current analysis. TyG index was calculated and divided into quartiles to explore the relationship with the outcomes of ischemic stroke. Outcomes included stroke recurrence, all-cause mortality, poor functional outcome at 12 months, and neurologic worsening at discharge. Multivariable Cox regression and logistic regression models were performed to explore the correlation of baseline TyG index with the outcomes.Results: Among the 16,310 patients enrolled in the study, the average age was 64.83 ± 11.9 years, and 63.48% were men. The median TyG index was 8.73 (interquartile range, 8.33–9.21). After adjustment for multiple potential covariates, the fourth quartile of TyG index was associated with an increased risk of stroke recurrence (adjusted HR, 1.32; 95% CI, 1.11–1.57; P = 0.002), all-cause mortality (adjusted HR, 1.25; 95%CI, 1.06–1.47; P = 0.01) at 12-month follow-up, and neurological worsening (adjusted OR, 1.26; 95% CI, 1.02–1.55; P = 0.03) at discharge, but not poor functional outcome compared with the first quartile.Conclusion: TyG index representing insulin resistance was associated with an increased risk of stroke recurrence, all-cause mortality, and neurologic worsening in patients with ischemic stroke.https://www.frontiersin.org/article/10.3389/fneur.2020.00456/fullinsulin resistancetriglyceride glucose indexischemic strokestroke recurrenceprognosis |
| spellingShingle | Yimo Zhou Yimo Zhou Yimo Zhou Yimo Zhou Yuesong Pan Yuesong Pan Yuesong Pan Yuesong Pan Hongyi Yan Hongyi Yan Hongyi Yan Hongyi Yan Yilong Wang Yilong Wang Yilong Wang Yilong Wang Zixiao Li Zixiao Li Zixiao Li Zixiao Li Xingquan Zhao Xingquan Zhao Xingquan Zhao Xingquan Zhao Hao Li Hao Li Hao Li Hao Li Xia Meng Xia Meng Xia Meng Xia Meng Chunxue Wang Chunxue Wang Chunxue Wang Chunxue Wang Liping Liu Liping Liu Liping Liu Liping Liu Yongjun Wang Yongjun Wang Yongjun Wang Yongjun Wang Triglyceride Glucose Index and Prognosis of Patients With Ischemic Stroke Frontiers in Neurology insulin resistance triglyceride glucose index ischemic stroke stroke recurrence prognosis |
| title | Triglyceride Glucose Index and Prognosis of Patients With Ischemic Stroke |
| title_full | Triglyceride Glucose Index and Prognosis of Patients With Ischemic Stroke |
| title_fullStr | Triglyceride Glucose Index and Prognosis of Patients With Ischemic Stroke |
| title_full_unstemmed | Triglyceride Glucose Index and Prognosis of Patients With Ischemic Stroke |
| title_short | Triglyceride Glucose Index and Prognosis of Patients With Ischemic Stroke |
| title_sort | triglyceride glucose index and prognosis of patients with ischemic stroke |
| topic | insulin resistance triglyceride glucose index ischemic stroke stroke recurrence prognosis |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.00456/full |
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