EZH2-miRNA Positive Feedback Promotes Tumor Growth in Ovarian Cancer

EZH2-miRNA Positive Feedback Promotes Tumor Growth in Ovarian Cancer

Enhancer of zester homolog 2 (EZH2), a histone methyl transferase that mediates H3K27me3 through polycomb repressive complex 2 (PRC2), is overexpressed in ovarian cancer and promotes malignant proliferation. However, the underlying mechanism of maintaining high EZH2 expression remains elusive. Here...

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Bibliographic Details
Main Authors: Ting Liu, Jian Cai, Jing Cai, Zehua Wang, Liqiong Cai
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Oncology
Subjects:
EZH2
H3K27me3
miRNA
ovarian cancer
positive feedback
proliferation
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.608393/full

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