Therapeutic potential of adipose-derived mesenchymal stem cell exosomes in tissue-engineered bladders
Mesenchymal stem cells (MSCs) are a therapeutic tool for tissue engineering. However, many studies have recently shown that the therapeutic effects of MSCs are mediated by paracrine signaling and their secretory factors rather than their multidirectional differentiation ability. Exosomes isolated fr...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-03-01
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| Series: | Journal of Tissue Engineering |
| Online Access: | https://doi.org/10.1177/20417314211001545 |
| _version_ | 1818917279808618496 |
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| author | Tianli Yang Feng Zhao Liuhua Zhou Jingyu Liu Luwei Xu Quanliang Dou Zheng Xu Ruipeng Jia |
| author_facet | Tianli Yang Feng Zhao Liuhua Zhou Jingyu Liu Luwei Xu Quanliang Dou Zheng Xu Ruipeng Jia |
| author_sort | Tianli Yang |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs) are a therapeutic tool for tissue engineering. However, many studies have recently shown that the therapeutic effects of MSCs are mediated by paracrine signaling and their secretory factors rather than their multidirectional differentiation ability. Exosomes isolated from the conditioned medium of MSCs are considered the main intercellular communication medium between MSCs and their target cells. Exosomes have been utilized in a novel cell-free therapy strategy that has attracted much attention. In this study, we evaluated the effects of a new cell-free tissue-engineered bladder (bladder acellular matrix combined with adipose-derived mesenchymal stem cell exosomes (AMEs)) in vivo and in vitro to prove that AMEs promoted tissue regeneration and functional recovery in a rat bladder replacement model. |
| first_indexed | 2024-12-20T00:31:33Z |
| format | Article |
| id | doaj.art-5426829ff29c4fb09c509a9f627a8cef |
| institution | Directory Open Access Journal |
| issn | 2041-7314 |
| language | English |
| last_indexed | 2024-12-20T00:31:33Z |
| publishDate | 2021-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Tissue Engineering |
| spelling | doaj.art-5426829ff29c4fb09c509a9f627a8cef2022-12-21T19:59:54ZengSAGE PublishingJournal of Tissue Engineering2041-73142021-03-011210.1177/20417314211001545Therapeutic potential of adipose-derived mesenchymal stem cell exosomes in tissue-engineered bladdersTianli YangFeng ZhaoLiuhua ZhouJingyu LiuLuwei XuQuanliang DouZheng XuRuipeng JiaMesenchymal stem cells (MSCs) are a therapeutic tool for tissue engineering. However, many studies have recently shown that the therapeutic effects of MSCs are mediated by paracrine signaling and their secretory factors rather than their multidirectional differentiation ability. Exosomes isolated from the conditioned medium of MSCs are considered the main intercellular communication medium between MSCs and their target cells. Exosomes have been utilized in a novel cell-free therapy strategy that has attracted much attention. In this study, we evaluated the effects of a new cell-free tissue-engineered bladder (bladder acellular matrix combined with adipose-derived mesenchymal stem cell exosomes (AMEs)) in vivo and in vitro to prove that AMEs promoted tissue regeneration and functional recovery in a rat bladder replacement model.https://doi.org/10.1177/20417314211001545 |
| spellingShingle | Tianli Yang Feng Zhao Liuhua Zhou Jingyu Liu Luwei Xu Quanliang Dou Zheng Xu Ruipeng Jia Therapeutic potential of adipose-derived mesenchymal stem cell exosomes in tissue-engineered bladders Journal of Tissue Engineering |
| title | Therapeutic potential of adipose-derived mesenchymal stem cell exosomes in tissue-engineered bladders |
| title_full | Therapeutic potential of adipose-derived mesenchymal stem cell exosomes in tissue-engineered bladders |
| title_fullStr | Therapeutic potential of adipose-derived mesenchymal stem cell exosomes in tissue-engineered bladders |
| title_full_unstemmed | Therapeutic potential of adipose-derived mesenchymal stem cell exosomes in tissue-engineered bladders |
| title_short | Therapeutic potential of adipose-derived mesenchymal stem cell exosomes in tissue-engineered bladders |
| title_sort | therapeutic potential of adipose derived mesenchymal stem cell exosomes in tissue engineered bladders |
| url | https://doi.org/10.1177/20417314211001545 |
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