Ferroptosis and Its Role in Chronic Diseases
Ferroptosis, which has been widely associated with many diseases, is an iron-dependent regulated cell death characterized by intracellular lipid peroxide accumulation. It exhibits morphological, biochemical, and genetic characteristics that are unique in comparison to other types of cell death. The...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/13/2040 |
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| author | Wenli Hu Kehong Liang Hong Zhu Chong Zhao Hongbo Hu Shutao Yin |
| author_facet | Wenli Hu Kehong Liang Hong Zhu Chong Zhao Hongbo Hu Shutao Yin |
| author_sort | Wenli Hu |
| collection | DOAJ |
| description | Ferroptosis, which has been widely associated with many diseases, is an iron-dependent regulated cell death characterized by intracellular lipid peroxide accumulation. It exhibits morphological, biochemical, and genetic characteristics that are unique in comparison to other types of cell death. The course of ferroptosis can be accurately regulated by the metabolism of iron, lipids, amino acids, and various signal pathways. In this review, we summarize the basic characteristics of ferroptosis, its regulation, as well as the relationship between ferroptosis and chronic diseases such as cancer, nervous system diseases, metabolic diseases, and inflammatory bowel diseases. Finally, we describe the regulatory effects of food-borne active ingredients on ferroptosis. |
| first_indexed | 2024-03-09T22:01:28Z |
| format | Article |
| id | doaj.art-54273f9e0c0e41e98d05cb8a99cad378 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T22:01:28Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-54273f9e0c0e41e98d05cb8a99cad3782023-11-23T19:48:30ZengMDPI AGCells2073-44092022-06-011113204010.3390/cells11132040Ferroptosis and Its Role in Chronic DiseasesWenli Hu0Kehong Liang1Hong Zhu2Chong Zhao3Hongbo Hu4Shutao Yin5College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaInstitute of Food and Nutrition Development, Ministry of Agriculture and Rural Affairs, Beijing 100083, ChinaInstitute of Food and Nutrition Development, Ministry of Agriculture and Rural Affairs, Beijing 100083, ChinaCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, ChinaFerroptosis, which has been widely associated with many diseases, is an iron-dependent regulated cell death characterized by intracellular lipid peroxide accumulation. It exhibits morphological, biochemical, and genetic characteristics that are unique in comparison to other types of cell death. The course of ferroptosis can be accurately regulated by the metabolism of iron, lipids, amino acids, and various signal pathways. In this review, we summarize the basic characteristics of ferroptosis, its regulation, as well as the relationship between ferroptosis and chronic diseases such as cancer, nervous system diseases, metabolic diseases, and inflammatory bowel diseases. Finally, we describe the regulatory effects of food-borne active ingredients on ferroptosis.https://www.mdpi.com/2073-4409/11/13/2040ferroptosisbasic characteristics of ferroptosisregulation of ferroptosischronic diseasesfood-borne active ingredients |
| spellingShingle | Wenli Hu Kehong Liang Hong Zhu Chong Zhao Hongbo Hu Shutao Yin Ferroptosis and Its Role in Chronic Diseases Cells ferroptosis basic characteristics of ferroptosis regulation of ferroptosis chronic diseases food-borne active ingredients |
| title | Ferroptosis and Its Role in Chronic Diseases |
| title_full | Ferroptosis and Its Role in Chronic Diseases |
| title_fullStr | Ferroptosis and Its Role in Chronic Diseases |
| title_full_unstemmed | Ferroptosis and Its Role in Chronic Diseases |
| title_short | Ferroptosis and Its Role in Chronic Diseases |
| title_sort | ferroptosis and its role in chronic diseases |
| topic | ferroptosis basic characteristics of ferroptosis regulation of ferroptosis chronic diseases food-borne active ingredients |
| url | https://www.mdpi.com/2073-4409/11/13/2040 |
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