PNPLA3 I148M Variant Impairs Liver X Receptor Signaling and Cholesterol Homeostasis in Human Hepatic Stellate Cells

PNPLA3 I148M Variant Impairs Liver X Receptor Signaling and Cholesterol Homeostasis in Human Hepatic Stellate Cells

The patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) I148M variant predisposes to hepatic steatosis and progression to advanced liver injury with development of fibrosis, cirrhosis, and cancer. Hepatic stellate cells (HSCs) drive the wound healing response to chronic injury, and lack...

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Bibliografische gegevens
Hoofdauteurs: Francesca Virginia Bruschi, Thierry Claudel, Matteo Tardelli, Patrick Starlinger, Fabio Marra, Michael Trauner
Formaat: Artikel
Taal:English
Gepubliceerd in: Wolters Kluwer Health/LWW 2019-09-01
Reeks:Hepatology Communications
Online toegang:https://doi.org/10.1002/hep4.1395

Internet

https://doi.org/10.1002/hep4.1395

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