Evaluation of costs related to antimicrobial resistance of priority Gram-negative bacilli
Introduction. Antimicrobial Resistance (AMR) is one of the most serious threats to global public health, causing over 700 thousand deaths annually. In addition to the social burden, AMR generates high medical costs, and estimating these at the hospital level has been the subject of research in many...
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| Format: | Article |
| Language: | English |
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Asociatia de Biosiguranta si Biosecuritate
2024-01-01
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| Series: | One Health & Risk Management |
| Subjects: | |
| Online Access: | https://journal.ohrm.bba.md/index.php/journal-ohrm-bba-md/article/view/682/638 |
| _version_ | 1797278760301494272 |
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| author | Maria ANTON Larisa PANTEA Olga BURDUNIUC Marcela CHILIANU Victoria BUCOV Livia TAPU |
| author_facet | Maria ANTON Larisa PANTEA Olga BURDUNIUC Marcela CHILIANU Victoria BUCOV Livia TAPU |
| author_sort | Maria ANTON |
| collection | DOAJ |
| description | Introduction. Antimicrobial Resistance (AMR) is one of the most serious threats to global public health, causing over 700 thousand deaths annually. In addition to the social burden, AMR generates high medical costs, and estimating these at the hospital level has been the subject of research in many international studies.
Material and methods. A comprehensive study was conducted, encompassing 172 cases of invasive infections recorded in patients hospitalized at the “Timofei Mosneaga” Republican Clinical Hospital, from which strains of antimicrobial-resistant E. coli, K. pneumoniae, A. baumannii, and P. aeruginosa were isolated in the years 2019-2021. Based on data regarding the duration of hospitalization, treatment costs, and expenses for investigations, indicators such as average cost, the median, minimum and maximum values of treatment, including the cost of antibiotics and laboratory analyses, were calculated.
Results. The economic impact indicators of AMR at the hospital level include: the duration of hospitalization, the total costs of a treated case, the costs of antibiotics, and the costs of laboratory analyses. In the structure of microorganisms isolated from the patients included in the study, K. pneumoniae predominates, accounting for 44.2%, and the total treatment cost for this organism was the highest at 202731.5 dollars. The maximum duration of hospitalization was recorded in patients from whom A. baumannii was isolated (27.7 days).
Conclusions. The resistance of strains isolated from patients has directly contributed to the extension of the hospitalization period. The resistance of A. baumannii and K. pneumoniae species has predominantly led to the increase in the economic burden of AMR. |
| first_indexed | 2024-03-07T16:12:52Z |
| format | Article |
| id | doaj.art-542f19bc700a434387760d22e8cf4fdb |
| institution | Directory Open Access Journal |
| issn | 2587-3458 2587-3466 |
| language | English |
| last_indexed | 2024-03-07T16:12:52Z |
| publishDate | 2024-01-01 |
| publisher | Asociatia de Biosiguranta si Biosecuritate |
| record_format | Article |
| series | One Health & Risk Management |
| spelling | doaj.art-542f19bc700a434387760d22e8cf4fdb2024-03-04T16:19:46ZengAsociatia de Biosiguranta si BiosecuritateOne Health & Risk Management2587-34582587-34662024-01-0151435010.38045/ohrm.2024.1.06Evaluation of costs related to antimicrobial resistance of priority Gram-negative bacilliMaria ANTON0https://orcid.org/0000-0002-4804-7137Larisa PANTEA1https://orcid.org/0000-0002-2392-560XOlga BURDUNIUC2https://orcid.org/0000-0002-6944-0800Marcela CHILIANU3https://orcid.org/0000-0002-0250-6684Victoria BUCOV4https://orcid.org/0009-0005-1042-5947Livia TAPU5https://orcid.org/0000-0002-4424-3501Nicolae Testemitanu State University of Medicine and Pharmacy; National Agency for Public Health,Chisinau, Republic of MoldovaNicolae Testemitanu State University of Medicine and Pharmacy; National Agency for Public Health,Chisinau, Republic of MoldovaNicolae Testemitanu State University of Medicine and Pharmacy; National Agency for Public Health,Chisinau, Republic of MoldovaNicolae TestemitanuState University of Medicine and Pharmacy; Timofei MosneagaRepublican Clinical Hospital, Chisinau, Republic of MoldovaNational Agency for Public Health,Chisinau, Republic of MoldovaNicolae TestemitanuState University of Medicine and Pharmacy; National Agency for Public Health,Chisinau, Republic of MoldovaIntroduction. Antimicrobial Resistance (AMR) is one of the most serious threats to global public health, causing over 700 thousand deaths annually. In addition to the social burden, AMR generates high medical costs, and estimating these at the hospital level has been the subject of research in many international studies. Material and methods. A comprehensive study was conducted, encompassing 172 cases of invasive infections recorded in patients hospitalized at the “Timofei Mosneaga” Republican Clinical Hospital, from which strains of antimicrobial-resistant E. coli, K. pneumoniae, A. baumannii, and P. aeruginosa were isolated in the years 2019-2021. Based on data regarding the duration of hospitalization, treatment costs, and expenses for investigations, indicators such as average cost, the median, minimum and maximum values of treatment, including the cost of antibiotics and laboratory analyses, were calculated. Results. The economic impact indicators of AMR at the hospital level include: the duration of hospitalization, the total costs of a treated case, the costs of antibiotics, and the costs of laboratory analyses. In the structure of microorganisms isolated from the patients included in the study, K. pneumoniae predominates, accounting for 44.2%, and the total treatment cost for this organism was the highest at 202731.5 dollars. The maximum duration of hospitalization was recorded in patients from whom A. baumannii was isolated (27.7 days). Conclusions. The resistance of strains isolated from patients has directly contributed to the extension of the hospitalization period. The resistance of A. baumannii and K. pneumoniae species has predominantly led to the increase in the economic burden of AMR.https://journal.ohrm.bba.md/index.php/journal-ohrm-bba-md/article/view/682/638economic impactantimicrobial resistancegram-negative bacilliinvasive infectionsburden of amr |
| spellingShingle | Maria ANTON Larisa PANTEA Olga BURDUNIUC Marcela CHILIANU Victoria BUCOV Livia TAPU Evaluation of costs related to antimicrobial resistance of priority Gram-negative bacilli One Health & Risk Management economic impact antimicrobial resistance gram-negative bacilli invasive infections burden of amr |
| title | Evaluation of costs related to antimicrobial resistance of priority Gram-negative bacilli |
| title_full | Evaluation of costs related to antimicrobial resistance of priority Gram-negative bacilli |
| title_fullStr | Evaluation of costs related to antimicrobial resistance of priority Gram-negative bacilli |
| title_full_unstemmed | Evaluation of costs related to antimicrobial resistance of priority Gram-negative bacilli |
| title_short | Evaluation of costs related to antimicrobial resistance of priority Gram-negative bacilli |
| title_sort | evaluation of costs related to antimicrobial resistance of priority gram negative bacilli |
| topic | economic impact antimicrobial resistance gram-negative bacilli invasive infections burden of amr |
| url | https://journal.ohrm.bba.md/index.php/journal-ohrm-bba-md/article/view/682/638 |
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