Tumor-infiltrating T cells as a risk factor for lymph node metastasis in patients with submucosal colorectal cancer
Abstract Approximately 10% of patients with colorectal cancer with submucosal invasion have lymph node metastasis. Pathological risk factors for lymph node metastasis have varying sensitivities and specificities. To predict the risk of lymph node metastasis, the identification of new risk factors is...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-29260-1 |
| _version_ | 1811165924605034496 |
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| author | Masatoshi Kitakaze Shiki Fujino Norikatsu Miyoshi Yuki Sekido Tsuyoshi Hata Takayuki Ogino Hidekazu Takahashi Mamoru Uemura Tsunekazu Mizushima Yuichiro Doki Hidetoshi Eguchi |
| author_facet | Masatoshi Kitakaze Shiki Fujino Norikatsu Miyoshi Yuki Sekido Tsuyoshi Hata Takayuki Ogino Hidekazu Takahashi Mamoru Uemura Tsunekazu Mizushima Yuichiro Doki Hidetoshi Eguchi |
| author_sort | Masatoshi Kitakaze |
| collection | DOAJ |
| description | Abstract Approximately 10% of patients with colorectal cancer with submucosal invasion have lymph node metastasis. Pathological risk factors for lymph node metastasis have varying sensitivities and specificities. To predict the risk of lymph node metastasis, the identification of new risk factors is vital. Tumor-infiltrating T cells have been reported to improve the prognosis of many solid tumors. Therefore, the purpose of this study was to examine the relationship between lymph node metastasis and tumor-infiltrating T cells in patients with colorectal cancer with submucosal invasion. We examined CD8+ tumor-infiltrating T cells level as a risk factor for lymph node metastasis in patients with colorectal cancer with submucosal invasion. Using immunohistochemical staining, we identified CD8 + T cells in surgically resected specimens from 98 patients with SM-CRC. We showed that low CD8+ tumor-infiltrating T cells levels are positively correlated with lymph node metastasis. Furthermore, by combining the number of CD8+ tumor-infiltrating T cell and the number of CD103+ tumor-infiltrating T cells, the results showed a high positive predictive value for lymph node metastasis in cases with low numbers of both types of tumor-infiltrating T cells and a high negative predictive value in cases with high numbers of both types of tumor-infiltrating T cells. |
| first_indexed | 2024-04-10T15:44:07Z |
| format | Article |
| id | doaj.art-542f5d8b97584d87aee952e54ebadaf5 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-10T15:44:07Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-542f5d8b97584d87aee952e54ebadaf52023-02-12T12:11:58ZengNature PortfolioScientific Reports2045-23222023-02-0113111110.1038/s41598-023-29260-1Tumor-infiltrating T cells as a risk factor for lymph node metastasis in patients with submucosal colorectal cancerMasatoshi Kitakaze0Shiki Fujino1Norikatsu Miyoshi2Yuki Sekido3Tsuyoshi Hata4Takayuki Ogino5Hidekazu Takahashi6Mamoru Uemura7Tsunekazu Mizushima8Yuichiro Doki9Hidetoshi Eguchi10Department of Gastroenterological Surgery, Osaka University Graduate School of MedicineDepartment of Gastroenterological Surgery, Osaka University Graduate School of MedicineDepartment of Gastroenterological Surgery, Osaka University Graduate School of MedicineDepartment of Gastroenterological Surgery, Osaka University Graduate School of MedicineDepartment of Gastroenterological Surgery, Osaka University Graduate School of MedicineDepartment of Gastroenterological Surgery, Osaka University Graduate School of MedicineDepartment of Gastroenterological Surgery, Osaka University Graduate School of MedicineDepartment of Gastroenterological Surgery, Osaka University Graduate School of MedicineDepartment of Gastroenterological Surgery, Osaka University Graduate School of MedicineDepartment of Gastroenterological Surgery, Osaka University Graduate School of MedicineDepartment of Gastroenterological Surgery, Osaka University Graduate School of MedicineAbstract Approximately 10% of patients with colorectal cancer with submucosal invasion have lymph node metastasis. Pathological risk factors for lymph node metastasis have varying sensitivities and specificities. To predict the risk of lymph node metastasis, the identification of new risk factors is vital. Tumor-infiltrating T cells have been reported to improve the prognosis of many solid tumors. Therefore, the purpose of this study was to examine the relationship between lymph node metastasis and tumor-infiltrating T cells in patients with colorectal cancer with submucosal invasion. We examined CD8+ tumor-infiltrating T cells level as a risk factor for lymph node metastasis in patients with colorectal cancer with submucosal invasion. Using immunohistochemical staining, we identified CD8 + T cells in surgically resected specimens from 98 patients with SM-CRC. We showed that low CD8+ tumor-infiltrating T cells levels are positively correlated with lymph node metastasis. Furthermore, by combining the number of CD8+ tumor-infiltrating T cell and the number of CD103+ tumor-infiltrating T cells, the results showed a high positive predictive value for lymph node metastasis in cases with low numbers of both types of tumor-infiltrating T cells and a high negative predictive value in cases with high numbers of both types of tumor-infiltrating T cells.https://doi.org/10.1038/s41598-023-29260-1 |
| spellingShingle | Masatoshi Kitakaze Shiki Fujino Norikatsu Miyoshi Yuki Sekido Tsuyoshi Hata Takayuki Ogino Hidekazu Takahashi Mamoru Uemura Tsunekazu Mizushima Yuichiro Doki Hidetoshi Eguchi Tumor-infiltrating T cells as a risk factor for lymph node metastasis in patients with submucosal colorectal cancer Scientific Reports |
| title | Tumor-infiltrating T cells as a risk factor for lymph node metastasis in patients with submucosal colorectal cancer |
| title_full | Tumor-infiltrating T cells as a risk factor for lymph node metastasis in patients with submucosal colorectal cancer |
| title_fullStr | Tumor-infiltrating T cells as a risk factor for lymph node metastasis in patients with submucosal colorectal cancer |
| title_full_unstemmed | Tumor-infiltrating T cells as a risk factor for lymph node metastasis in patients with submucosal colorectal cancer |
| title_short | Tumor-infiltrating T cells as a risk factor for lymph node metastasis in patients with submucosal colorectal cancer |
| title_sort | tumor infiltrating t cells as a risk factor for lymph node metastasis in patients with submucosal colorectal cancer |
| url | https://doi.org/10.1038/s41598-023-29260-1 |
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