Acute exposure to air pollutants increase the risk of acute glaucoma
Abstract Background Ambient air pollution is related to the onset and progression of ocular disease. However, the effect of air pollutants on the acute glaucoma remains unclear. Objective To investigate the effect of air pollutants on the incidence of acute glaucoma (acute angle closure glaucoma and...
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | BMC Public Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12889-022-14078-9 |
| _version_ | 1818475088860676096 |
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| author | Liping Li Yixiang Zhu Binze Han Renjie Chen Xiaofei Man Xinghuai Sun Haidong Kan Yuan Lei |
| author_facet | Liping Li Yixiang Zhu Binze Han Renjie Chen Xiaofei Man Xinghuai Sun Haidong Kan Yuan Lei |
| author_sort | Liping Li |
| collection | DOAJ |
| description | Abstract Background Ambient air pollution is related to the onset and progression of ocular disease. However, the effect of air pollutants on the acute glaucoma remains unclear. Objective To investigate the effect of air pollutants on the incidence of acute glaucoma (acute angle closure glaucoma and glaucomatocyclitic crisis) among adults. Methods We conducted a time-stratified case-crossover study based on the data of glaucoma outpatients from January, 2015 to Dec, 2021 in Shanghai, China. A conditional logistic regression model combined with a polynomial distributed lag model was applied for the statistical analysis. Each case serves as its own referent by comparing exposures on the day of the outpatient visit to the exposures on the other 3–4 control days on the same week, month and year. To fully capture the delayed effect of air pollution, we used a maximum lag of 7 days in main model. Results A total of 14,385 acute glaucoma outpatients were included in this study. We found exposure to PM2.5, PM10, nitrogen dioxide (NO2) and carbon monoxide (CO) significantly increased the odds of outpatient visit for acute glaucoma. Wherein the odds of acute glaucoma related to PM2.5 and NO2 were higher and more sustained, with OR of 1.07 (95%CI: 1.03–1.11) and 1.12 (95% CI: 1.08–1.17) for an IQR increase over lag 0–3 days, than PM10 and CO over lag 0–1 days (OR:1.03; 95% CI: 1.01–1.05; OR: 1.04; 95% CI: 1.01–1.07). Conclusions This case-crossover study provided first-hand evidence that air pollutants, especially PM2.5 and NO2, significantly increased risk of acute glaucoma. |
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| format | Article |
| id | doaj.art-5430311592b546fb8fedff4eb612dc70 |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-04-14T07:17:50Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-5430311592b546fb8fedff4eb612dc702022-12-22T02:06:15ZengBMCBMC Public Health1471-24582022-09-0122111010.1186/s12889-022-14078-9Acute exposure to air pollutants increase the risk of acute glaucomaLiping Li0Yixiang Zhu1Binze Han2Renjie Chen3Xiaofei Man4Xinghuai Sun5Haidong Kan6Yuan Lei7Department of Ophthalmology & Visual Science, Eye Institute, Eye & ENT Hospital, Shanghai Medical College, Fudan UniversitySchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, IRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan UniversityDepartment of Ophthalmology & Visual Science, Eye Institute, Eye & ENT Hospital, Shanghai Medical College, Fudan UniversitySchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, IRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan UniversityDepartment of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Ophthalmology & Visual Science, Eye Institute, Eye & ENT Hospital, Shanghai Medical College, Fudan UniversitySchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, IRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan UniversityDepartment of Ophthalmology & Visual Science, Eye Institute, Eye & ENT Hospital, Shanghai Medical College, Fudan UniversityAbstract Background Ambient air pollution is related to the onset and progression of ocular disease. However, the effect of air pollutants on the acute glaucoma remains unclear. Objective To investigate the effect of air pollutants on the incidence of acute glaucoma (acute angle closure glaucoma and glaucomatocyclitic crisis) among adults. Methods We conducted a time-stratified case-crossover study based on the data of glaucoma outpatients from January, 2015 to Dec, 2021 in Shanghai, China. A conditional logistic regression model combined with a polynomial distributed lag model was applied for the statistical analysis. Each case serves as its own referent by comparing exposures on the day of the outpatient visit to the exposures on the other 3–4 control days on the same week, month and year. To fully capture the delayed effect of air pollution, we used a maximum lag of 7 days in main model. Results A total of 14,385 acute glaucoma outpatients were included in this study. We found exposure to PM2.5, PM10, nitrogen dioxide (NO2) and carbon monoxide (CO) significantly increased the odds of outpatient visit for acute glaucoma. Wherein the odds of acute glaucoma related to PM2.5 and NO2 were higher and more sustained, with OR of 1.07 (95%CI: 1.03–1.11) and 1.12 (95% CI: 1.08–1.17) for an IQR increase over lag 0–3 days, than PM10 and CO over lag 0–1 days (OR:1.03; 95% CI: 1.01–1.05; OR: 1.04; 95% CI: 1.01–1.07). Conclusions This case-crossover study provided first-hand evidence that air pollutants, especially PM2.5 and NO2, significantly increased risk of acute glaucoma.https://doi.org/10.1186/s12889-022-14078-9Air pollutantsAcute glaucomaCase-crossover study |
| spellingShingle | Liping Li Yixiang Zhu Binze Han Renjie Chen Xiaofei Man Xinghuai Sun Haidong Kan Yuan Lei Acute exposure to air pollutants increase the risk of acute glaucoma BMC Public Health Air pollutants Acute glaucoma Case-crossover study |
| title | Acute exposure to air pollutants increase the risk of acute glaucoma |
| title_full | Acute exposure to air pollutants increase the risk of acute glaucoma |
| title_fullStr | Acute exposure to air pollutants increase the risk of acute glaucoma |
| title_full_unstemmed | Acute exposure to air pollutants increase the risk of acute glaucoma |
| title_short | Acute exposure to air pollutants increase the risk of acute glaucoma |
| title_sort | acute exposure to air pollutants increase the risk of acute glaucoma |
| topic | Air pollutants Acute glaucoma Case-crossover study |
| url | https://doi.org/10.1186/s12889-022-14078-9 |
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