Modulation of cerebral cortex activity by acupuncture in patients with prolonged disorder of consciousness: An fNIRS study
Background and objectiveAcupuncture is a promising non-pharmacological therapy for patients with prolonged disorder of consciousness (PDOC); however, its underlying mechanism remains uncertain. This study aimed to reveal the modulatory effects of acupuncture on the cerebral cortex activity among pat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.1043133/full |
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| author | Yiwei Liu Yiwei Liu Ning Sun Ning Sun Jing Xiong Jing Xiong Yuanfang Zhou Xiangyin Ye Hua Jiang Hua Jiang Hua Guo Hua Guo Na Zhi Jingkang Lu Jingkang Lu Peijue He Peijue He Huilin Yang Huilin Yang Qingbin Li Qingbin Li Ruirui Sun Jing He Jing He |
| author_facet | Yiwei Liu Yiwei Liu Ning Sun Ning Sun Jing Xiong Jing Xiong Yuanfang Zhou Xiangyin Ye Hua Jiang Hua Jiang Hua Guo Hua Guo Na Zhi Jingkang Lu Jingkang Lu Peijue He Peijue He Huilin Yang Huilin Yang Qingbin Li Qingbin Li Ruirui Sun Jing He Jing He |
| author_sort | Yiwei Liu |
| collection | DOAJ |
| description | Background and objectiveAcupuncture is a promising non-pharmacological therapy for patients with prolonged disorder of consciousness (PDOC); however, its underlying mechanism remains uncertain. This study aimed to reveal the modulatory effects of acupuncture on the cerebral cortex activity among patients with PDOC.Materials and methodsTwenty-eight PDOC patients were randomly assigned to the treatment (n = 14) or control (n = 14) group. The treatment group received one session of acupuncture, while the control group received one session of sham acupuncture. All patients underwent evaluation of the functional connectivity and activation response of the dorsolateral prefrontal cortex (DLPFC), primary motor cortex (M1), and primary somatosensory cortex (S1) via functional near-infrared spectroscopy. We further explored the potential correlation of the consciousness level and activation response/functional connectivity with acupuncture.ResultsCompared to the control group, a single session of acupuncture significantly tended to enhance resting-state functional connectivity (rsFC) in DLPFC-M1, DLPFC-M1, and S1-S1. And the activation level of the DLPFC (both sides) in the acupuncture group is significantly higher than those in sham acupuncture group. However, no significant correlation was found between the consciousness level and activation response/functional connectivity.ConclusionOne session of acupuncture has a significant modulation of rsFC and activation in the DLPFC, M1, and S1 with PDOC patients. Acupuncture-evoked effect may have some functional significance in PDOC patients. This is an important step toward exploring the acupuncture effects on PDOC patients. |
| first_indexed | 2024-04-11T07:42:53Z |
| format | Article |
| id | doaj.art-54333be222c847e3826ae2a46ef136ed |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-11T07:42:53Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-54333be222c847e3826ae2a46ef136ed2022-12-22T04:36:25ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-11-011610.3389/fnins.2022.10431331043133Modulation of cerebral cortex activity by acupuncture in patients with prolonged disorder of consciousness: An fNIRS studyYiwei Liu0Yiwei Liu1Ning Sun2Ning Sun3Jing Xiong4Jing Xiong5Yuanfang Zhou6Xiangyin Ye7Hua Jiang8Hua Jiang9Hua Guo10Hua Guo11Na Zhi12Jingkang Lu13Jingkang Lu14Peijue He15Peijue He16Huilin Yang17Huilin Yang18Qingbin Li19Qingbin Li20Ruirui Sun21Jing He22Jing He23Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Rehabilitation Medicine in Sichuan Province, Chengdu, Sichuan, ChinaRehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Rehabilitation Medicine in Sichuan Province, Chengdu, Sichuan, ChinaRehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Rehabilitation Medicine in Sichuan Province, Chengdu, Sichuan, ChinaAcupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaAcupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaRehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Rehabilitation Medicine in Sichuan Province, Chengdu, Sichuan, ChinaRehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Rehabilitation Medicine in Sichuan Province, Chengdu, Sichuan, ChinaAcupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaRehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Rehabilitation Medicine in Sichuan Province, Chengdu, Sichuan, ChinaRehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Rehabilitation Medicine in Sichuan Province, Chengdu, Sichuan, ChinaRehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Rehabilitation Medicine in Sichuan Province, Chengdu, Sichuan, ChinaRehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Rehabilitation Medicine in Sichuan Province, Chengdu, Sichuan, ChinaAcupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaRehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaKey Laboratory of Rehabilitation Medicine in Sichuan Province, Chengdu, Sichuan, ChinaBackground and objectiveAcupuncture is a promising non-pharmacological therapy for patients with prolonged disorder of consciousness (PDOC); however, its underlying mechanism remains uncertain. This study aimed to reveal the modulatory effects of acupuncture on the cerebral cortex activity among patients with PDOC.Materials and methodsTwenty-eight PDOC patients were randomly assigned to the treatment (n = 14) or control (n = 14) group. The treatment group received one session of acupuncture, while the control group received one session of sham acupuncture. All patients underwent evaluation of the functional connectivity and activation response of the dorsolateral prefrontal cortex (DLPFC), primary motor cortex (M1), and primary somatosensory cortex (S1) via functional near-infrared spectroscopy. We further explored the potential correlation of the consciousness level and activation response/functional connectivity with acupuncture.ResultsCompared to the control group, a single session of acupuncture significantly tended to enhance resting-state functional connectivity (rsFC) in DLPFC-M1, DLPFC-M1, and S1-S1. And the activation level of the DLPFC (both sides) in the acupuncture group is significantly higher than those in sham acupuncture group. However, no significant correlation was found between the consciousness level and activation response/functional connectivity.ConclusionOne session of acupuncture has a significant modulation of rsFC and activation in the DLPFC, M1, and S1 with PDOC patients. Acupuncture-evoked effect may have some functional significance in PDOC patients. This is an important step toward exploring the acupuncture effects on PDOC patients.https://www.frontiersin.org/articles/10.3389/fnins.2022.1043133/fullacupunctureneuroplasticityfunctional near-infrared spectroscopy (fNIRS)prolonged disorder of consciousnessdorsolateral prefrontal cortex (DLPFC) |
| spellingShingle | Yiwei Liu Yiwei Liu Ning Sun Ning Sun Jing Xiong Jing Xiong Yuanfang Zhou Xiangyin Ye Hua Jiang Hua Jiang Hua Guo Hua Guo Na Zhi Jingkang Lu Jingkang Lu Peijue He Peijue He Huilin Yang Huilin Yang Qingbin Li Qingbin Li Ruirui Sun Jing He Jing He Modulation of cerebral cortex activity by acupuncture in patients with prolonged disorder of consciousness: An fNIRS study Frontiers in Neuroscience acupuncture neuroplasticity functional near-infrared spectroscopy (fNIRS) prolonged disorder of consciousness dorsolateral prefrontal cortex (DLPFC) |
| title | Modulation of cerebral cortex activity by acupuncture in patients with prolonged disorder of consciousness: An fNIRS study |
| title_full | Modulation of cerebral cortex activity by acupuncture in patients with prolonged disorder of consciousness: An fNIRS study |
| title_fullStr | Modulation of cerebral cortex activity by acupuncture in patients with prolonged disorder of consciousness: An fNIRS study |
| title_full_unstemmed | Modulation of cerebral cortex activity by acupuncture in patients with prolonged disorder of consciousness: An fNIRS study |
| title_short | Modulation of cerebral cortex activity by acupuncture in patients with prolonged disorder of consciousness: An fNIRS study |
| title_sort | modulation of cerebral cortex activity by acupuncture in patients with prolonged disorder of consciousness an fnirs study |
| topic | acupuncture neuroplasticity functional near-infrared spectroscopy (fNIRS) prolonged disorder of consciousness dorsolateral prefrontal cortex (DLPFC) |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.1043133/full |
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