Effect of Mechanical Loading Timeline on Periosteal Bone Formation
Timeline factors such as the rest interval between load cycles were, as well as the many factors that characterize dynamic mechanical loading to bone, reported to have significant effects on bone formation. Noticing the possible importance of timeline-dependent phenomena in mechanotransduction, we e...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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The Japan Society of Mechanical Engineers
2008-06-01
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| Series: | Journal of Biomechanical Science and Engineering |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jbse/3/2/3_2_176/_pdf/-char/en |
| _version_ | 1811292406681698304 |
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| author | Hiroko N. MATSUMOTO Yoshihisa KOYAMA Kazuo TAKAKUDA |
| author_facet | Hiroko N. MATSUMOTO Yoshihisa KOYAMA Kazuo TAKAKUDA |
| author_sort | Hiroko N. MATSUMOTO |
| collection | DOAJ |
| description | Timeline factors such as the rest interval between load cycles were, as well as the many factors that characterize dynamic mechanical loading to bone, reported to have significant effects on bone formation. Noticing the possible importance of timeline-dependent phenomena in mechanotransduction, we examined the effects of both the duration of constant load and the duration of rest interval in a 3-point bending model for rat tibiae. A square-wave loading was used, in which loading waveform was composed of constant load and rest periods. Newly formed bones were labeled with fluorescent dyes, and the amounts of new bone were measured using confocal laser microscopy. Loading to the medial surface of tibiae with a waveform composed of 0.5 s of constant load and 39.5 s of rest periods induced bone formation on the medial surface, whereas that composed of 39.5 s of constant load and 0.5 sec of rest periods induced bone formation on the lateral surface. Furthermore, the length of the rest period and the number of loading cycles were found to have significant effects on the amount of bone formation. Based on these results, a hypothetical mechanism on the mechanotransduction system in bone was discussed. |
| first_indexed | 2024-04-13T04:45:00Z |
| format | Article |
| id | doaj.art-5435cc92d5be4fdd90b5437310bdd1ac |
| institution | Directory Open Access Journal |
| issn | 1880-9863 |
| language | English |
| last_indexed | 2024-04-13T04:45:00Z |
| publishDate | 2008-06-01 |
| publisher | The Japan Society of Mechanical Engineers |
| record_format | Article |
| series | Journal of Biomechanical Science and Engineering |
| spelling | doaj.art-5435cc92d5be4fdd90b5437310bdd1ac2022-12-22T03:01:52ZengThe Japan Society of Mechanical EngineersJournal of Biomechanical Science and Engineering1880-98632008-06-013217618710.1299/jbse.3.176jbseEffect of Mechanical Loading Timeline on Periosteal Bone FormationHiroko N. MATSUMOTO0Yoshihisa KOYAMA1Kazuo TAKAKUDA2Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental UniversityInstitute of Biomaterials and Bioengineering, Tokyo Medical and Dental UniversityInstitute of Biomaterials and Bioengineering, Tokyo Medical and Dental UniversityTimeline factors such as the rest interval between load cycles were, as well as the many factors that characterize dynamic mechanical loading to bone, reported to have significant effects on bone formation. Noticing the possible importance of timeline-dependent phenomena in mechanotransduction, we examined the effects of both the duration of constant load and the duration of rest interval in a 3-point bending model for rat tibiae. A square-wave loading was used, in which loading waveform was composed of constant load and rest periods. Newly formed bones were labeled with fluorescent dyes, and the amounts of new bone were measured using confocal laser microscopy. Loading to the medial surface of tibiae with a waveform composed of 0.5 s of constant load and 39.5 s of rest periods induced bone formation on the medial surface, whereas that composed of 39.5 s of constant load and 0.5 sec of rest periods induced bone formation on the lateral surface. Furthermore, the length of the rest period and the number of loading cycles were found to have significant effects on the amount of bone formation. Based on these results, a hypothetical mechanism on the mechanotransduction system in bone was discussed.https://www.jstage.jst.go.jp/article/jbse/3/2/3_2_176/_pdf/-char/enbiomechanicsbone remodelingloading timelinecompressive stress |
| spellingShingle | Hiroko N. MATSUMOTO Yoshihisa KOYAMA Kazuo TAKAKUDA Effect of Mechanical Loading Timeline on Periosteal Bone Formation Journal of Biomechanical Science and Engineering biomechanics bone remodeling loading timeline compressive stress |
| title | Effect of Mechanical Loading Timeline on Periosteal Bone Formation |
| title_full | Effect of Mechanical Loading Timeline on Periosteal Bone Formation |
| title_fullStr | Effect of Mechanical Loading Timeline on Periosteal Bone Formation |
| title_full_unstemmed | Effect of Mechanical Loading Timeline on Periosteal Bone Formation |
| title_short | Effect of Mechanical Loading Timeline on Periosteal Bone Formation |
| title_sort | effect of mechanical loading timeline on periosteal bone formation |
| topic | biomechanics bone remodeling loading timeline compressive stress |
| url | https://www.jstage.jst.go.jp/article/jbse/3/2/3_2_176/_pdf/-char/en |
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