PROBLEM OF GENERIC REPLACEMENT: ADVANTAGES AND DISADVANTAGES
<p>The main differences between original and generic drugs as well as registration criteria for generics are described. Possible reasons of discrepancy in bioequivalence and therapeutic equivalence of original and generic drugs are reviewed. The examples of such a discrepancy as a result of co...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2016-01-01
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| Series: | Рациональная фармакотерапия в кардиологии |
| Subjects: | |
| Online Access: | http://www.rpcardio.ru/jour/article/view/599 |
| _version_ | 1827840724966572032 |
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| author | S. N. Tolpygina S. Yu. Martsevich |
| author_facet | S. N. Tolpygina S. Yu. Martsevich |
| author_sort | S. N. Tolpygina |
| collection | DOAJ |
| description | <p>The main differences between original and generic drugs as well as registration criteria for generics are described. Possible reasons of discrepancy in bioequivalence and therapeutic equivalence of original and generic drugs are reviewed. The examples of such a discrepancy as a result of comparative clinical trails (enalapril maleate) are discussed. Approaches to planning of comparative trails on drug therapeutic equivalence are presented. </p> |
| first_indexed | 2024-03-12T07:38:13Z |
| format | Article |
| id | doaj.art-543771fa736540c2ab55ebd86d3518cc |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2024-03-12T07:38:13Z |
| publishDate | 2016-01-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-543771fa736540c2ab55ebd86d3518cc2023-09-02T21:25:15ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532016-01-0151636810.1234/1819-6446-2009-1-63-68598PROBLEM OF GENERIC REPLACEMENT: ADVANTAGES AND DISADVANTAGESS. N. Tolpygina0S. Yu. Martsevich1Государственный научно-исследовательский центр профилактической медицины РосмедтехнологийГосударственный научно-исследовательский центр профилактической медицины Росмедтехнологий<p>The main differences between original and generic drugs as well as registration criteria for generics are described. Possible reasons of discrepancy in bioequivalence and therapeutic equivalence of original and generic drugs are reviewed. The examples of such a discrepancy as a result of comparative clinical trails (enalapril maleate) are discussed. Approaches to planning of comparative trails on drug therapeutic equivalence are presented. </p>http://www.rpcardio.ru/jour/article/view/599оригинальные и дженерические препаратыэналаприлбиоэквивалентностьтерапевтическая эквивалентностьсравнительные исследования |
| spellingShingle | S. N. Tolpygina S. Yu. Martsevich PROBLEM OF GENERIC REPLACEMENT: ADVANTAGES AND DISADVANTAGES Рациональная фармакотерапия в кардиологии оригинальные и дженерические препараты эналаприл биоэквивалентность терапевтическая эквивалентность сравнительные исследования |
| title | PROBLEM OF GENERIC REPLACEMENT: ADVANTAGES AND DISADVANTAGES |
| title_full | PROBLEM OF GENERIC REPLACEMENT: ADVANTAGES AND DISADVANTAGES |
| title_fullStr | PROBLEM OF GENERIC REPLACEMENT: ADVANTAGES AND DISADVANTAGES |
| title_full_unstemmed | PROBLEM OF GENERIC REPLACEMENT: ADVANTAGES AND DISADVANTAGES |
| title_short | PROBLEM OF GENERIC REPLACEMENT: ADVANTAGES AND DISADVANTAGES |
| title_sort | problem of generic replacement advantages and disadvantages |
| topic | оригинальные и дженерические препараты эналаприл биоэквивалентность терапевтическая эквивалентность сравнительные исследования |
| url | http://www.rpcardio.ru/jour/article/view/599 |
| work_keys_str_mv | AT sntolpygina problemofgenericreplacementadvantagesanddisadvantages AT syumartsevich problemofgenericreplacementadvantagesanddisadvantages |