BAG Family Members as Mitophagy Regulators in Mammals
The BCL-2-associated athanogene (BAG) family is a multifunctional group of co-chaperones that are evolutionarily conserved from yeast to mammals. In addition to their common BAG domain, these proteins contain, in their sequences, many specific domains/motifs required for their various functions in c...
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| Format: | Article |
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MDPI AG
2022-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/4/681 |
| _version_ | 1797481827119661056 |
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| author | Sophie Pattingre Andrei Turtoi |
| author_facet | Sophie Pattingre Andrei Turtoi |
| author_sort | Sophie Pattingre |
| collection | DOAJ |
| description | The BCL-2-associated athanogene (BAG) family is a multifunctional group of co-chaperones that are evolutionarily conserved from yeast to mammals. In addition to their common BAG domain, these proteins contain, in their sequences, many specific domains/motifs required for their various functions in cellular quality control, such as autophagy, apoptosis, and proteasomal degradation of misfolded proteins. The BAG family includes six members (BAG1 to BAG6). Recent studies reported their roles in autophagy and/or mitophagy through interaction with the autophagic machinery (LC3, Beclin 1, P62) or with the PINK1/Parkin signaling pathway. This review describes the mechanisms underlying BAG family member functions in autophagy and mitophagy and the consequences in physiopathology. |
| first_indexed | 2024-03-09T22:20:06Z |
| format | Article |
| id | doaj.art-543783293a4d45408d9a2b1fe0c073f8 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T22:20:06Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-543783293a4d45408d9a2b1fe0c073f82023-11-23T19:15:14ZengMDPI AGCells2073-44092022-02-0111468110.3390/cells11040681BAG Family Members as Mitophagy Regulators in MammalsSophie Pattingre0Andrei Turtoi1Tumor Microenvironment and Resistance to Treatment Laboratory, Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier, 34298 Montpellier, FranceTumor Microenvironment and Resistance to Treatment Laboratory, Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier, 34298 Montpellier, FranceThe BCL-2-associated athanogene (BAG) family is a multifunctional group of co-chaperones that are evolutionarily conserved from yeast to mammals. In addition to their common BAG domain, these proteins contain, in their sequences, many specific domains/motifs required for their various functions in cellular quality control, such as autophagy, apoptosis, and proteasomal degradation of misfolded proteins. The BAG family includes six members (BAG1 to BAG6). Recent studies reported their roles in autophagy and/or mitophagy through interaction with the autophagic machinery (LC3, Beclin 1, P62) or with the PINK1/Parkin signaling pathway. This review describes the mechanisms underlying BAG family member functions in autophagy and mitophagy and the consequences in physiopathology.https://www.mdpi.com/2073-4409/11/4/681autophagymitophagyquality controlBAG |
| spellingShingle | Sophie Pattingre Andrei Turtoi BAG Family Members as Mitophagy Regulators in Mammals Cells autophagy mitophagy quality control BAG |
| title | BAG Family Members as Mitophagy Regulators in Mammals |
| title_full | BAG Family Members as Mitophagy Regulators in Mammals |
| title_fullStr | BAG Family Members as Mitophagy Regulators in Mammals |
| title_full_unstemmed | BAG Family Members as Mitophagy Regulators in Mammals |
| title_short | BAG Family Members as Mitophagy Regulators in Mammals |
| title_sort | bag family members as mitophagy regulators in mammals |
| topic | autophagy mitophagy quality control BAG |
| url | https://www.mdpi.com/2073-4409/11/4/681 |
| work_keys_str_mv | AT sophiepattingre bagfamilymembersasmitophagyregulatorsinmammals AT andreiturtoi bagfamilymembersasmitophagyregulatorsinmammals |