Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis
Purpose: To report on a case of uveitis and scleritis resulting as an immune-mediated side effect of cancer immunotherapy with nivolumab and cabiralizumab. Observations: Bilateral anterior nongranulomatous anterior uveitis and bilateral diffuse anterior and posterior scleritis occurred following the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-06-01
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| Series: | American Journal of Ophthalmology Case Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451993617301044 |
| _version_ | 1818301215976456192 |
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| author | John A. Gonzales Jessica Shantha Nisha R. Acharya |
| author_facet | John A. Gonzales Jessica Shantha Nisha R. Acharya |
| author_sort | John A. Gonzales |
| collection | DOAJ |
| description | Purpose: To report on a case of uveitis and scleritis resulting as an immune-mediated side effect of cancer immunotherapy with nivolumab and cabiralizumab. Observations: Bilateral anterior nongranulomatous anterior uveitis and bilateral diffuse anterior and posterior scleritis occurred following the use of combination cancer immunotherapy. The uveitis and scleritis resolved following temporary discontinuation of nivolumab and cabiralizumab as well as systemic prednisone. Conclusions and importance: Ophthalmologists should be aware of the possibility of acute ocular inflammation developing with cancer immunotherapy. Systemic corticosteroids play a first-line role in managing such immune-mediated side effects. Keywords: Uveitis, Scleritis, Cancer immunotherapy, Side effects, Nivolumab, Cabiralizumab |
| first_indexed | 2024-12-13T05:19:29Z |
| format | Article |
| id | doaj.art-5438dff8fce54bbcb0bc52594199bbfd |
| institution | Directory Open Access Journal |
| issn | 2451-9936 |
| language | English |
| last_indexed | 2024-12-13T05:19:29Z |
| publishDate | 2018-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Ophthalmology Case Reports |
| spelling | doaj.art-5438dff8fce54bbcb0bc52594199bbfd2022-12-21T23:58:21ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362018-06-0110117118Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitisJohn A. Gonzales0Jessica Shantha1Nisha R. Acharya2F.I. Proctor Foundation, University of California, San Francisco, United States; Department of Ophthalmology, University of California, San Francisco, United States; Corresponding author. F.I. Proctor Foundation, Department of Ophthalmology, University of California, San Francisco, 95 Kirkham Street, San Francisco, CA, 94147, United States.F.I. Proctor Foundation, University of California, San Francisco, United States; Department of Ophthalmology, University of California, San Francisco, United StatesF.I. Proctor Foundation, University of California, San Francisco, United States; Department of Ophthalmology, University of California, San Francisco, United StatesPurpose: To report on a case of uveitis and scleritis resulting as an immune-mediated side effect of cancer immunotherapy with nivolumab and cabiralizumab. Observations: Bilateral anterior nongranulomatous anterior uveitis and bilateral diffuse anterior and posterior scleritis occurred following the use of combination cancer immunotherapy. The uveitis and scleritis resolved following temporary discontinuation of nivolumab and cabiralizumab as well as systemic prednisone. Conclusions and importance: Ophthalmologists should be aware of the possibility of acute ocular inflammation developing with cancer immunotherapy. Systemic corticosteroids play a first-line role in managing such immune-mediated side effects. Keywords: Uveitis, Scleritis, Cancer immunotherapy, Side effects, Nivolumab, Cabiralizumabhttp://www.sciencedirect.com/science/article/pii/S2451993617301044 |
| spellingShingle | John A. Gonzales Jessica Shantha Nisha R. Acharya Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis American Journal of Ophthalmology Case Reports |
| title | Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis |
| title_full | Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis |
| title_fullStr | Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis |
| title_full_unstemmed | Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis |
| title_short | Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis |
| title_sort | combination nivolumab and cabiralizumab associated acute bilateral anterior and posterior scleritis and anterior uveitis |
| url | http://www.sciencedirect.com/science/article/pii/S2451993617301044 |
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