Asymptomatic Hyperuricemia Associates with Cardiometabolic Risk Indicators in Overweight/Obese but Not in Lean Adolescents
Katarina Sebekova,1 Radana Gurecka,1,2 Ludmila Podracka3,4 1Institute of Molecular BioMedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia; 2Institute of Medical Physics, Biophysics, Informatics and Telemedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia; 3De...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-10-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| Online Access: | https://www.dovepress.com/asymptomatic-hyperuricemia-associates-with-cardiometabolic-risk-indica-peer-reviewed-article-DMSO |
| _version_ | 1797936166285082624 |
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| author | Sebekova K Gurecka R Podracka L |
| author_facet | Sebekova K Gurecka R Podracka L |
| author_sort | Sebekova K |
| collection | DOAJ |
| description | Katarina Sebekova,1 Radana Gurecka,1,2 Ludmila Podracka3,4 1Institute of Molecular BioMedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia; 2Institute of Medical Physics, Biophysics, Informatics and Telemedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia; 3Department of Pediatrics, Faculty of Medicine, Comenius University, Bratislava, Slovakia; 4The National Institute of Children’s Health, Bratislava, SlovakiaCorrespondence: Katarina SebekovaInstitute of Molecular BioMedicine, Medical Faculty, Comenius University, Sasinkova 4, 811 08 Bratislava, SlovakiaTel +421-2-9011-9429Fax +421-2-9011-9631Email kata.sebekova@gmail.comPurpose: In overweight/obese adolescents, asymptomatic hyperuricemia is associated with increased prevalence of metabolic syndrome, its components, and a higher cardiometabolic risk. Whether similar associations exist in lean hyperuricemic adolescents is unknown.Subjects and Methods: In 2424 adolescents (51.9% females) aged 16– 19 years, anthropometric variables, blood pressure, uric acid, glucose, insulin, lipid profile, inflammatory markers, and renal function were determined. Continuous cardiometabolic score was calculated. Normouricemic vs hyperuricemic subjects were compared among lean and overweight/obese individuals of both sexes.Results: Females (5.4%) and males (13.3%) presented with hyperuricemia; among them 63% of females and 53% of males were lean. In both sexes, hyperuricemic lean and hyperuricemic overweight/obese adolescents displayed similar uric acid concentrations (eg, males: 455± 30 vs 461± 32 μmol/L, respectively, p=0.933). Lean normouricemic adolescents manifested significantly lower uric acid levels than their overweight/obese peers (eg, males: 333± 46 vs 357± 41 μmol/L, respectively, p< 0.001). Lean normouricemic and hyperuricemic subjects presented similar cardiometabolic score (eg, males: 2.60± 0.67 vs 2.64± 0.60, respectively, p=0.998); among overweight/obese adolescents those with hyperuricemia displayed higher scores compared with their normouricemic counterparts (eg, males: 3.36± 1.04 vs 4.21± 1.65, respectively, p< 0.001). A decision-tree model revealed phenotypes associated with higher uricemia, however, distribution of individuals with hyperuricemia among phenotypes was random.Conclusion: In lean adolescents, hyperuricemia is not associated with cardiometabolic profile indicating an increased risk. Existence of this rather prevalent phenotype remains undetected unless lean and overweight/obese subjects are analyzed separately. Longitudinal studies are needed to elucidate the potential clinical consequences of asymptomatic hyperuricemia in lean subjects in later life.Keywords: uric acid, continuous cardiometabolic score, sex-difference, obesity, lean phenotype |
| first_indexed | 2024-04-10T18:25:28Z |
| format | Article |
| id | doaj.art-543a808869e2467582efb84befe08c50 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T18:25:28Z |
| publishDate | 2020-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-543a808869e2467582efb84befe08c502023-02-02T05:52:27ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072020-10-01Volume 133977399258501Asymptomatic Hyperuricemia Associates with Cardiometabolic Risk Indicators in Overweight/Obese but Not in Lean AdolescentsSebekova KGurecka RPodracka LKatarina Sebekova,1 Radana Gurecka,1,2 Ludmila Podracka3,4 1Institute of Molecular BioMedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia; 2Institute of Medical Physics, Biophysics, Informatics and Telemedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia; 3Department of Pediatrics, Faculty of Medicine, Comenius University, Bratislava, Slovakia; 4The National Institute of Children’s Health, Bratislava, SlovakiaCorrespondence: Katarina SebekovaInstitute of Molecular BioMedicine, Medical Faculty, Comenius University, Sasinkova 4, 811 08 Bratislava, SlovakiaTel +421-2-9011-9429Fax +421-2-9011-9631Email kata.sebekova@gmail.comPurpose: In overweight/obese adolescents, asymptomatic hyperuricemia is associated with increased prevalence of metabolic syndrome, its components, and a higher cardiometabolic risk. Whether similar associations exist in lean hyperuricemic adolescents is unknown.Subjects and Methods: In 2424 adolescents (51.9% females) aged 16– 19 years, anthropometric variables, blood pressure, uric acid, glucose, insulin, lipid profile, inflammatory markers, and renal function were determined. Continuous cardiometabolic score was calculated. Normouricemic vs hyperuricemic subjects were compared among lean and overweight/obese individuals of both sexes.Results: Females (5.4%) and males (13.3%) presented with hyperuricemia; among them 63% of females and 53% of males were lean. In both sexes, hyperuricemic lean and hyperuricemic overweight/obese adolescents displayed similar uric acid concentrations (eg, males: 455± 30 vs 461± 32 μmol/L, respectively, p=0.933). Lean normouricemic adolescents manifested significantly lower uric acid levels than their overweight/obese peers (eg, males: 333± 46 vs 357± 41 μmol/L, respectively, p< 0.001). Lean normouricemic and hyperuricemic subjects presented similar cardiometabolic score (eg, males: 2.60± 0.67 vs 2.64± 0.60, respectively, p=0.998); among overweight/obese adolescents those with hyperuricemia displayed higher scores compared with their normouricemic counterparts (eg, males: 3.36± 1.04 vs 4.21± 1.65, respectively, p< 0.001). A decision-tree model revealed phenotypes associated with higher uricemia, however, distribution of individuals with hyperuricemia among phenotypes was random.Conclusion: In lean adolescents, hyperuricemia is not associated with cardiometabolic profile indicating an increased risk. Existence of this rather prevalent phenotype remains undetected unless lean and overweight/obese subjects are analyzed separately. Longitudinal studies are needed to elucidate the potential clinical consequences of asymptomatic hyperuricemia in lean subjects in later life.Keywords: uric acid, continuous cardiometabolic score, sex-difference, obesity, lean phenotypehttps://www.dovepress.com/asymptomatic-hyperuricemia-associates-with-cardiometabolic-risk-indica-peer-reviewed-article-DMSOuric acidcontinuous cardiometabolic scoresex-differenceobesitylean phenotype |
| spellingShingle | Sebekova K Gurecka R Podracka L Asymptomatic Hyperuricemia Associates with Cardiometabolic Risk Indicators in Overweight/Obese but Not in Lean Adolescents Diabetes, Metabolic Syndrome and Obesity uric acid continuous cardiometabolic score sex-difference obesity lean phenotype |
| title | Asymptomatic Hyperuricemia Associates with Cardiometabolic Risk Indicators in Overweight/Obese but Not in Lean Adolescents |
| title_full | Asymptomatic Hyperuricemia Associates with Cardiometabolic Risk Indicators in Overweight/Obese but Not in Lean Adolescents |
| title_fullStr | Asymptomatic Hyperuricemia Associates with Cardiometabolic Risk Indicators in Overweight/Obese but Not in Lean Adolescents |
| title_full_unstemmed | Asymptomatic Hyperuricemia Associates with Cardiometabolic Risk Indicators in Overweight/Obese but Not in Lean Adolescents |
| title_short | Asymptomatic Hyperuricemia Associates with Cardiometabolic Risk Indicators in Overweight/Obese but Not in Lean Adolescents |
| title_sort | asymptomatic hyperuricemia associates with cardiometabolic risk indicators in overweight obese but not in lean adolescents |
| topic | uric acid continuous cardiometabolic score sex-difference obesity lean phenotype |
| url | https://www.dovepress.com/asymptomatic-hyperuricemia-associates-with-cardiometabolic-risk-indica-peer-reviewed-article-DMSO |
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