Phenolic Compounds of <i>Rhodiola rosea</i> L. as the Potential Alternative Therapy in the Treatment of Chronic Diseases
The roots and rhizomes of <i>Rhodiola rosea</i> L. (Crassulaceae), which is widely growing in Northern Europe, North America, and Siberia, have been used since ancient times to alleviate stress, fatigue, and mental and physical disorders. Phenolic compounds: phenylpropanoids rosavin, ros...
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MDPI AG
2023-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/15/12293 |
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| author | Jurga Bernatoniene Valdas Jakstas Dalia M. Kopustinskiene |
| author_facet | Jurga Bernatoniene Valdas Jakstas Dalia M. Kopustinskiene |
| author_sort | Jurga Bernatoniene |
| collection | DOAJ |
| description | The roots and rhizomes of <i>Rhodiola rosea</i> L. (Crassulaceae), which is widely growing in Northern Europe, North America, and Siberia, have been used since ancient times to alleviate stress, fatigue, and mental and physical disorders. Phenolic compounds: phenylpropanoids rosavin, rosarin, and rosin, tyrosol glucoside salidroside, and tyrosol, are responsible for the biological action of <i>R. rosea</i>, exerting antioxidant, immunomodulatory, anti-aging, anti-fatigue activities. <i>R. rosea</i> extract formulations are used as alternative remedies to enhance mental and cognitive functions and protect the central nervous system and heart during stress. Recent studies indicate that <i>R. rosea</i> may be used to treat diabetes, cancer, and a variety of cardiovascular and neurological disorders such as Alzheimer’s and Parkinson’s diseases. This paper reviews the beneficial effects of the extract of <i>R. rosea</i>, its key active components, and their possible use in the treatment of chronic diseases. <i>R. rosea</i> represents an excellent natural remedy to address situations involving decreased performance, such as fatigue and a sense of weakness, particularly in the context of chronic diseases. Given the significance of mitochondria in cellular energy metabolism and their vulnerability to reactive oxygen species, future research should prioritize investigating the potential effects of <i>R. rosea</i> main bioactive phenolic compounds on mitochondria, thus targeting cellular energy supply and countering oxidative stress-related effects. |
| first_indexed | 2024-03-11T00:25:21Z |
| format | Article |
| id | doaj.art-543baed2674c4d7b8068d8735c837517 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T00:25:21Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-543baed2674c4d7b8068d8735c8375172023-11-18T23:03:04ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-07-0124151229310.3390/ijms241512293Phenolic Compounds of <i>Rhodiola rosea</i> L. as the Potential Alternative Therapy in the Treatment of Chronic DiseasesJurga Bernatoniene0Valdas Jakstas1Dalia M. Kopustinskiene2Institute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, LT-50161 Kaunas, LithuaniaInstitute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, LT-50161 Kaunas, LithuaniaInstitute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, LT-50161 Kaunas, LithuaniaThe roots and rhizomes of <i>Rhodiola rosea</i> L. (Crassulaceae), which is widely growing in Northern Europe, North America, and Siberia, have been used since ancient times to alleviate stress, fatigue, and mental and physical disorders. Phenolic compounds: phenylpropanoids rosavin, rosarin, and rosin, tyrosol glucoside salidroside, and tyrosol, are responsible for the biological action of <i>R. rosea</i>, exerting antioxidant, immunomodulatory, anti-aging, anti-fatigue activities. <i>R. rosea</i> extract formulations are used as alternative remedies to enhance mental and cognitive functions and protect the central nervous system and heart during stress. Recent studies indicate that <i>R. rosea</i> may be used to treat diabetes, cancer, and a variety of cardiovascular and neurological disorders such as Alzheimer’s and Parkinson’s diseases. This paper reviews the beneficial effects of the extract of <i>R. rosea</i>, its key active components, and their possible use in the treatment of chronic diseases. <i>R. rosea</i> represents an excellent natural remedy to address situations involving decreased performance, such as fatigue and a sense of weakness, particularly in the context of chronic diseases. Given the significance of mitochondria in cellular energy metabolism and their vulnerability to reactive oxygen species, future research should prioritize investigating the potential effects of <i>R. rosea</i> main bioactive phenolic compounds on mitochondria, thus targeting cellular energy supply and countering oxidative stress-related effects.https://www.mdpi.com/1422-0067/24/15/12293<i>Rhodiola rosea</i> L.phenolic compoundssalidrosidechronic diseasescancer |
| spellingShingle | Jurga Bernatoniene Valdas Jakstas Dalia M. Kopustinskiene Phenolic Compounds of <i>Rhodiola rosea</i> L. as the Potential Alternative Therapy in the Treatment of Chronic Diseases International Journal of Molecular Sciences <i>Rhodiola rosea</i> L. phenolic compounds salidroside chronic diseases cancer |
| title | Phenolic Compounds of <i>Rhodiola rosea</i> L. as the Potential Alternative Therapy in the Treatment of Chronic Diseases |
| title_full | Phenolic Compounds of <i>Rhodiola rosea</i> L. as the Potential Alternative Therapy in the Treatment of Chronic Diseases |
| title_fullStr | Phenolic Compounds of <i>Rhodiola rosea</i> L. as the Potential Alternative Therapy in the Treatment of Chronic Diseases |
| title_full_unstemmed | Phenolic Compounds of <i>Rhodiola rosea</i> L. as the Potential Alternative Therapy in the Treatment of Chronic Diseases |
| title_short | Phenolic Compounds of <i>Rhodiola rosea</i> L. as the Potential Alternative Therapy in the Treatment of Chronic Diseases |
| title_sort | phenolic compounds of i rhodiola rosea i l as the potential alternative therapy in the treatment of chronic diseases |
| topic | <i>Rhodiola rosea</i> L. phenolic compounds salidroside chronic diseases cancer |
| url | https://www.mdpi.com/1422-0067/24/15/12293 |
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