ECM1 regulates the resistance of colorectal cancer to 5-FU treatment by modulating apoptotic cell death and epithelial-mesenchymal transition induction

ECM1 regulates the resistance of colorectal cancer to 5-FU treatment by modulating apoptotic cell death and epithelial-mesenchymal transition induction

5-Fluorouracil (5-FU) chemoresistance is a persistent impediment to the efficient treatment of many types of cancer, yet the molecular mechanisms underlying such resistance remain incompletely understood. Here we found CRC patients resistant to 5-FU treatment exhibited increased extracellular matrix...

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Bibliographic Details
Main Authors: Sirui Long, Jie Wang, Fanbin Weng, Zhigang Pei, Shixian Zhou, Guiyin Sun, Debing Xiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Pharmacology
Subjects:
ECM1
drug resistance
colorectal cancer
cell apoptosis
epithelial-mesenchymal transition
PI3K/AKT/GSK3βsignaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1005915/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1005915/full

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