An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation
By comprehensively mapping the impact that different classes of mutations (substitutions, insertions, deletions) have on the ability of the amyloid beta peptide to nucleate amyloids, the authors identify a large set of likely pathogenic variants of amyloid beta that are specifically enriched at its...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34742-3 |
| _version_ | 1811319279753101312 |
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| author | Mireia Seuma Ben Lehner Benedetta Bolognesi |
| author_facet | Mireia Seuma Ben Lehner Benedetta Bolognesi |
| author_sort | Mireia Seuma |
| collection | DOAJ |
| description | By comprehensively mapping the impact that different classes of mutations (substitutions, insertions, deletions) have on the ability of the amyloid beta peptide to nucleate amyloids, the authors identify a large set of likely pathogenic variants of amyloid beta that are specifically enriched at its polar N-terminal region. |
| first_indexed | 2024-04-13T12:40:01Z |
| format | Article |
| id | doaj.art-543e0138c85844bd99e798ce4f2a34fe |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T12:40:01Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-543e0138c85844bd99e798ce4f2a34fe2022-12-22T02:46:33ZengNature PortfolioNature Communications2041-17232022-11-0113111310.1038/s41467-022-34742-3An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleationMireia Seuma0Ben Lehner1Benedetta Bolognesi2Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and TechnologyCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyInstitute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and TechnologyBy comprehensively mapping the impact that different classes of mutations (substitutions, insertions, deletions) have on the ability of the amyloid beta peptide to nucleate amyloids, the authors identify a large set of likely pathogenic variants of amyloid beta that are specifically enriched at its polar N-terminal region.https://doi.org/10.1038/s41467-022-34742-3 |
| spellingShingle | Mireia Seuma Ben Lehner Benedetta Bolognesi An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation Nature Communications |
| title | An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation |
| title_full | An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation |
| title_fullStr | An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation |
| title_full_unstemmed | An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation |
| title_short | An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation |
| title_sort | atlas of amyloid aggregation the impact of substitutions insertions deletions and truncations on amyloid beta fibril nucleation |
| url | https://doi.org/10.1038/s41467-022-34742-3 |
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