Inhibition of Arenaviridae nucleoprotein exonuclease by bisphosphonate

Inhibition of Arenaviridae nucleoprotein exonuclease by bisphosphonate

Arenaviruses are emerging enveloped negative-sense RNA viruses that cause neurological and hemorrhagic diseases in humans. Currently, no FDA-approved vaccine or therapeutic agent is available except for ribavirin, which must be administered early during infection for optimum efficacy. A hallmark of...

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Bibliographic Details
Main Authors: Thi Hong Van Nguyen, Elsie Yekwa, Barbara Selisko, Bruno Canard, Karine Alvarez, François Ferron
Format: Article
Language:English
Published: International Union of Crystallography 2022-07-01
Series:IUCrJ
Subjects:
arenaviridae
exonucleases
mopeia virus
lymphocytic choriomeningitis virus
lassa virus
alendronate
compound optimization
metal chelation
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2052252522005061

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http://scripts.iucr.org/cgi-bin/paper?S2052252522005061

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