Electrospun Nanomaterials Based on Cellulose and Its Derivatives for Cell Cultures: Recent Developments and Challenges
The development of electrospun nanofibers based on cellulose and its derivatives is an inalienable task of modern materials science branches related to biomedical engineering. The considerable compatibility with multiple cell lines and capability to form unaligned nanofibrous frameworks help reprodu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/15/5/1174 |
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| author | Kristina Peranidze Tatiana V. Safronova Nataliya R. Kildeeva |
| author_facet | Kristina Peranidze Tatiana V. Safronova Nataliya R. Kildeeva |
| author_sort | Kristina Peranidze |
| collection | DOAJ |
| description | The development of electrospun nanofibers based on cellulose and its derivatives is an inalienable task of modern materials science branches related to biomedical engineering. The considerable compatibility with multiple cell lines and capability to form unaligned nanofibrous frameworks help reproduce the properties of natural extracellular matrix and ensure scaffold applications as cell carriers promoting substantial cell adhesion, growth, and proliferation. In this paper, we are focusing on the structural features of cellulose itself and electrospun cellulosic fibers, including fiber diameter, spacing, and alignment responsible for facilitated cell capture. The study emphasizes the role of the most frequently discussed cellulose derivatives (cellulose acetate, carboxymethylcellulose, hydroxypropyl cellulose, etc.) and composites in scaffolding and cell culturing. The key issues of the electrospinning technique in scaffold design and insufficient micromechanics assessment are discussed. Based on recent studies aiming at the fabrication of artificial 2D and 3D nanofiber matrices, the current research provides the applicability assessment of the scaffolds toward osteoblasts (hFOB line), fibroblastic (NIH/3T3, HDF, HFF-1, L929 lines), endothelial (HUVEC line), and several other cell types. Furthermore, a critical aspect of cell adhesion through the adsorption of proteins on the surfaces is touched upon. |
| first_indexed | 2024-03-11T07:13:34Z |
| format | Article |
| id | doaj.art-543f71e5fe614655aba622d9577850f3 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-11T07:13:34Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-543f71e5fe614655aba622d9577850f32023-11-17T08:27:11ZengMDPI AGPolymers2073-43602023-02-01155117410.3390/polym15051174Electrospun Nanomaterials Based on Cellulose and Its Derivatives for Cell Cultures: Recent Developments and ChallengesKristina Peranidze0Tatiana V. Safronova1Nataliya R. Kildeeva2Department of Materials Science, Lomonosov Moscow State University, Leninskie Gory 1, Building 73, 119991 Moscow, RussiaDepartment of Materials Science, Lomonosov Moscow State University, Leninskie Gory 1, Building 73, 119991 Moscow, RussiaDepartment of Chemistry and Technology of Polymer Materials and Nanocomposites, The Kosygin State University of Russia, Malaya Kaluzhskaya 1, 119071 Moscow, RussiaThe development of electrospun nanofibers based on cellulose and its derivatives is an inalienable task of modern materials science branches related to biomedical engineering. The considerable compatibility with multiple cell lines and capability to form unaligned nanofibrous frameworks help reproduce the properties of natural extracellular matrix and ensure scaffold applications as cell carriers promoting substantial cell adhesion, growth, and proliferation. In this paper, we are focusing on the structural features of cellulose itself and electrospun cellulosic fibers, including fiber diameter, spacing, and alignment responsible for facilitated cell capture. The study emphasizes the role of the most frequently discussed cellulose derivatives (cellulose acetate, carboxymethylcellulose, hydroxypropyl cellulose, etc.) and composites in scaffolding and cell culturing. The key issues of the electrospinning technique in scaffold design and insufficient micromechanics assessment are discussed. Based on recent studies aiming at the fabrication of artificial 2D and 3D nanofiber matrices, the current research provides the applicability assessment of the scaffolds toward osteoblasts (hFOB line), fibroblastic (NIH/3T3, HDF, HFF-1, L929 lines), endothelial (HUVEC line), and several other cell types. Furthermore, a critical aspect of cell adhesion through the adsorption of proteins on the surfaces is touched upon.https://www.mdpi.com/2073-4360/15/5/1174scaffoldselectrospun nanofiberscelluloseextracellular matrixcell culture |
| spellingShingle | Kristina Peranidze Tatiana V. Safronova Nataliya R. Kildeeva Electrospun Nanomaterials Based on Cellulose and Its Derivatives for Cell Cultures: Recent Developments and Challenges Polymers scaffolds electrospun nanofibers cellulose extracellular matrix cell culture |
| title | Electrospun Nanomaterials Based on Cellulose and Its Derivatives for Cell Cultures: Recent Developments and Challenges |
| title_full | Electrospun Nanomaterials Based on Cellulose and Its Derivatives for Cell Cultures: Recent Developments and Challenges |
| title_fullStr | Electrospun Nanomaterials Based on Cellulose and Its Derivatives for Cell Cultures: Recent Developments and Challenges |
| title_full_unstemmed | Electrospun Nanomaterials Based on Cellulose and Its Derivatives for Cell Cultures: Recent Developments and Challenges |
| title_short | Electrospun Nanomaterials Based on Cellulose and Its Derivatives for Cell Cultures: Recent Developments and Challenges |
| title_sort | electrospun nanomaterials based on cellulose and its derivatives for cell cultures recent developments and challenges |
| topic | scaffolds electrospun nanofibers cellulose extracellular matrix cell culture |
| url | https://www.mdpi.com/2073-4360/15/5/1174 |
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